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Cited by 726

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Translational control in the endoplasmic reticulum stress response

Open access
Ron, David·2002·Journal of Clinical Investigation
DOI 10.1172/jci0216784
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Abstract

From the perspective of protein biosynthesis, the endoplasmic reticulum (ER) can be viewed as a processing plant for folding and posttranslational modification of secreted and integral membrane proteins.At any given time, the load of client proteins that the ER must handle is set by developmental programs and modulated by physiological considerations.Specific signaling pathways and effector mechanisms have evolved to deal with the temporal and developmental variation in ER load experienced by different cells in mutlicellular organisms.The upstream signal that activates these pathways is referred to as ER stress and is defined functionally as an imbalance between the load of client proteins facing the ER and the organelle's ability to process that load.ER stress can be provoked by a variety of pathophysiological conditions, for example, ischemia, hyperhomocystinemia, viral infections, and mutations that impair client protein folding (1-4).However, the phenotypes of mutations affecting components of the ER stress-response machinery reveal that ER stress is also a normal physiological phenomenon (reviewed in ref. 5).

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Metadata

Authors
Ron, D.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
2002-11-15
Volume
110
Issue
10
Pages
1383-1388
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci0216784
OpenAlex
W4248136323
Cited by
726
References
6
FWCI
11.77
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Translational control in the endoplasmic reticulum stress response. https://app.cochat.ai/papers/10.1172/jci0216784
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Ron, D. (2002). Translational control in the endoplasmic reticulum stress response. Journal of Clinical Investigation. https://doi.org/10.1172/jci0216784

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.