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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Open accessAbstract
TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies in vivo, we show here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice. In addition, we show that the induction of GLP-1 release in enteroendocrine cells by 6alpha-ethyl-23(S)-methyl-cholic acid (EMCA, INT-777), a specific TGR5 agonist, is linked to an increase of the intracellular ATP/ADP ratio and a subsequent rise in intracellular calcium mobilization. Altogether, these data show that the TGR5 signaling pathway is critical in regulating intestinal GLP-1 secretion in vivo, and suggest that pharmacological targeting of TGR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
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In the citing paper
“Bacteria-derived secondary bile acids (lithocholic acid, deoxycholic acid) can activate the G-protein coupled bile acid receptor Gpbar1 receptor (TGR5) in L cells, promoting the peripheral release of GLP-1 and PYY (Katsuma et al., 2005;Thomas et al., 2009;Ullmer et al., 2013).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Thomas et al., 2009
Experimental — accuracy not yet measuredIn the citing paper
“Bile acids induce insulin secretion directly via the transmembrane bile acid receptor Takeda G protein–coupled receptor 5 (on β cells and indirectly via stimulation of l-cell derived GLP-1 and subsequent insulin release (110–112).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [112]
In the citing paper
“TGR5 is therefore a new and attractive target for treating obesity, since it can theoretically protect against obesity and its complications via two distinct and potentially synergistic mechanisms: increased energy expenditure and improved insulin sensitivity 148.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
In the citing paper
“Bile acids also increase energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin. This effect is dependent on induction of the type 2 iodothyronine deiodinase and is mediated by the binding of bile acids to a novel G-protein-coupled receptor TGR5 148.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
In the citing paper
“Bile acids also increase energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin. This effect is dependent on induction of the type 2 iodothyronine deiodinase and is mediated by the binding of bile acids to a novel G-protein-coupled receptor TGR5 148.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
In the citing paper
“One promising TGR5 agonist, INT-777, has already shown efficacy in vivo, increasing energy expenditure and reducing adiposity in mice with diet-induced obesity 148,149.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
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Citations
Cites
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
Drucker, D. J., & Nauck, M. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69705-5 · Cited by 3,896
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
Self-citationThe biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,580
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,425
Self-citationTargeting bile‐acid signalling for metabolic diseases
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., & Schoonjans, K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2619 · Cited by 1,422 · cited 2×
“The complete absence of changes in the expression level of classical target genes of FXR in the liver, such as cholesterol 7a hydroxylase (CYP7A1) and bile salt export pump (BSEP) (Thomas et al., 2008), further confirmed the specificity of INT-777 toward TGR5 (Figure S6B).”
BackgroundSelf-citationIdentification of membrane-type receptor for bile acids (M-BAR)
Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
Zhang, Y., Lee, F. Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506982103 · Cited by 974
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Hu, X. Y., Chandler, J. D., Orr, M. L., Hao, L., Liu, K., Uppal, K., Go, Y., & Jones, D. P. (2018) · Journal of Nutrition · doi:10.1093/jn/nxy036 · Cited by 74
Fujisaka, S., Usui, I., Nawaz, A., Igarashi, Y., Okabe, K., Furusawa, Y., Watanabe, S., Yamamoto, S., Sasahara, M., Watanabe, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62506-w · Cited by 75
Li, B., Zhang, J., Chen, Y., Wang, Q., Li, Y., Wang, R., Wei, Y., You, Z., Li, Y., Miao, Q., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1946366 · Cited by 74
Recent Progress on Bile Acid Receptor Modulators for Treatment of Metabolic Diseases
Xu, Y. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00342 · Cited by 75
INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function
Comeglio, P., Cellai, I., Mello, T., Filippi, S., Maneschi, E., Corcetto, F., Corno, C., Sarchielli, E., Morelli, A., Rapizzi, E., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0557 · Cited by 74
Xu, G., & Song, M. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.08.028 · Cited by 74
Pezzino, S., Sofia, M., Faletra, G., Mazzone, C., Litrico, G., Greca, G. L., & Latteri, S. (2022) · Biology · doi:10.3390/biology11111622 · Cited by 77
Role of the Gut Microbiome in the Development of Atherosclerotic Cardiovascular Disease
Samarraie, A. A., Pichette, M., & Rousseau, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065420 · Cited by 78
Arab, J. P., Arrese, M. A., & Shah, V. H. (2019) · Hepatology Research · doi:10.1111/hepr.13473 · Cited by 76
The Role of the Gut Microbiota in Coronary Heart Disease
Liu, H., Zhuang, J., Tang, P., Li, J., Xiong, X., & Deng, H. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00892-2 · Cited by 76
Multi-omics profiling: the way toward precision medicine in metabolic diseases
Hu, C., & Jia, W. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab051 · Cited by 75
Molecular Regulation of Bile Acid Homeostasis
Choudhuri, S., & Klaassen, C. D. (2021) · Drug Metabolism and Disposition · doi:10.1124/dmd.121.000643 · Cited by 79
Involvement of glucagon‐like peptide‐1 in the glucose‐lowering effect of metformin
Bahne, E., Hansen, M., Brønden, A., Sonne, D. P., Vilsbøll, T., & Knop, F. K. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12697 · Cited by 73
Eblimit, Z., Thevananther, S., Karpen, S. J., Taegtmeyer, H., Moore, D. D., Adorini, L., Penny, D. J., & Desai, M. S. (2018) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12462 · Cited by 74
Digesting the complex metabolic effects of diet on the host and microbiome
Carmody, R. N., Varady, K. A., & Turnbaugh, P. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.032 · Cited by 76
Liaset, B., Hao, Q., Jørgensen, H. J. H., Hallenborg, P., Du, Z., Ma, T., Marschall, H., Kruhøffer, M., Li, R., Li, Q., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.234732 · Cited by 72
Watanabe, K., Igarashi, M., Li, X., Nakatani, A., Miyamoto, J., Inaba, Y., Sutou, A., Saito, T., Sato, T., Tachibana, N., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202083 · Cited by 73
Metabolism amelioration of Dendrobium officinale polysaccharide on type II diabetic rats
Chen, H., Nie, Q., Hu, J., Huang, X., Huang, W., & Nie, S. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105582 · Cited by 70
Bile acid receptors and signaling crosstalk in the liver, gut and brain
Ferrell, J. M., & Chiang, J. Y. L. (2021) · Liver Research · doi:10.1016/j.livres.2021.07.002 · Cited by 72
Ciaula, A. D., Bonfrate, L., Baj, J., Khalil, M., Garruti, G., Stellaard, F., Wang, H. H., Wang, D. Q. ‐., & Portincasa, P. (2022) · Nutrients · doi:10.3390/nu14234950 · Cited by 76
Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery
Arble, D. M., Sandoval, D. A., & Seeley, R. J. (2014) · Diabetologia · doi:10.1007/s00125-014-3433-3 · Cited by 74
Sombetzki, M., Fuchs, C. D., Fickert, P., Österreicher, C. H., Mueller, M., Claudel, T., Loebermann, M., Engelmann, R., Langner, C., Sahin, E., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.020 · Cited by 69
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, C. B., Trammell, S. A. J., Albrechtsen, N. J. W., Schoonjans, K., Albrechtsen, R., Gillum, M. P., Kuhre, R. E., & Holst, J. J. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00010.2019 · Cited by 69
Self-citationBile acid receptors and the kidney
Herman‐Edelstein, M., Weinstein, T., & Levi, M. (2017) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000374 · Cited by 70
Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis
Suga, T., Yamaguchi, H., Ogura, J., Shoji, S., Maekawa, M., & Mano, N. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114664 · Cited by 70
Publisher Correction: The gut–liver axis and the intersection with the microbiome
Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0031-8 · Cited by 70
Wang, B., Kong, Q., Cui, S., Xiu, L., Gu, Z., Zhao, J., Zhang, H., Chen, W., & Wang, G. (2021) · Nutrients · doi:10.3390/nu13031017 · Cited by 69
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Li, T., Hasan, M. N., & Gu, L. (2024) · eGastroenterology · doi:10.1136/egastro-2024-100074 · Cited by 75
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Daoudi, M., Hennuyer, N., Borland, M. G., Touche, V., Duhem, C., Gross, B. S., Caiazzo, R. J., Kerr-Conte, J. A., Pattou, F. N., Peters, J. M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.045 · Cited by 73
Role of enterohepatic recirculation in drug disposition: cooperation and complications
Malik, M. Y., Jaiswal, S., Sharma, A., Shukla, M. K., & Lal, J. (2016) · Drug Metabolism Reviews · doi:10.3109/03602532.2016.1157600 · Cited by 70
Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions
Ryan, P. M., Stanton, C., & Caplice, N. M. (2017) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-017-0299-9 · Cited by 70
Jena, P. K., Sheng, L., McNeil, K. D., Chau, T., Yu, S., Kiuru, M. H., Fung, M. A., Hwang, S. T., & Wan, Y. Y. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.05.007 · Cited by 67
Bildziukevich, U., Özdemir, Z., & Wimmer, Z. (2019) · Molecules · doi:10.3390/molecules24193546 · Cited by 67
Maczewsky, J., Kaiser, J., Gresch, A., Gerst, F., Düfer, M., Krippeit‐Drews, P., & Drews, G. (2018) · Diabetes · doi:10.2337/db18-0315 · Cited by 69
Wang, X. X., Xie, C., Libby, A. E., Ranjit, S., Levi, J., Myakala, K., Bhasin, K., Jones, B. A., Orlicky, D. J., Takahashi, S., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102530 · Cited by 72
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Cheng, M., Ren, L., Jia, X., Wang, J., & Cong, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1347047 · Cited by 78
The role of bile acids in functional GI disorders
Appleby, R., & Walters, J. R. F. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12370 · Cited by 66
Ferrell, J. M., Pathak, P., Boehme, S., Gilliland, T., & Chiang, J. Y. L. (2019) · Hepatology · doi:10.1002/hep.30513 · Cited by 65
Chèvre, R., Trigueros‐Motos, L., Castaño, D., Chua, T., Corlianò, M., Patankar, J. V., Sng, L., Sim, L., Juin, T. L., Carissimo, G., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201701084rr · Cited by 68
Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?
Jiang, L., & Schnabl, B. (2020) · Physiology · doi:10.1152/physiol.00005.2020 · Cited by 64
Gut microbiota: a non-target victim of pesticide-induced toxicity
Sharma, T., Natesh, N. S., Pothuraju, R., Batra, S. K., & Rachagani, S. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2187578 · Cited by 68
Jameson, K. G., Kazmi, S. A., Ohara, T. E., Son, C., Yu, K. B., Mazdeyasnan, D., Leshan, E., Vuong, H. E., Paramo, J., Lopez-Romero, A., et al. (2024) · iScience · doi:10.1016/j.isci.2024.111699 · Cited by 88
Sonne, D. P., Rehfeld, J. F., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0309 · Cited by 65
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Meng, Z., Liu, L., Yan, S., Sun, W., Jia, M., Tian, S., Huang, S., Zhou, Z., & Zhu, W. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04678 · Cited by 66
Host-microbial interactions in the metabolism of different dietary fats
Chadaideh, K. S., & Carmody, R. N. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.011 · Cited by 63
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Sędzikowska, A., & Szablewski, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413440 · Cited by 71
Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
Zhang, W., Dong, X. Y., & Huang, R. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01096-3 · Cited by 68
The future of incretin‐based therapy: novel avenues—novel targets
Åhrén, B. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01457.x · Cited by 62
Huang, S., Ma, S.-Y., Ning, M., Yang, W., Ye, Y., Zhang, L., Shen, J., & Leng, Y. (2019) · Metabolism · doi:10.1016/j.metabol.2019.07.003 · Cited by 64
From obesity through gut microbiota to cardiovascular diseases: a dangerous journey
Marzullo, P., Renzo, L. D., Pugliese, G., Siena, M. D., Barrea, L., Muscogiuri, G., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0017-1 · Cited by 64
Gut microbiota and its metabolites: Bridge of dietary nutrients and obesity-related diseases
Zhou, M., Johnston, L. J., Wu, C., & Ma, X. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1986466 · Cited by 67
Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota
Flaig, B., Garza, R., Singh, B., Hamamah, S., & Covașă, M. (2023) · Nutrients · doi:10.3390/nu15010228 · Cited by 65
Vliex, L. M. M., Penders, J., Nauta, A., Zoetendal, E. G., & Blaak, E. E. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-00966-0 · Cited by 71
Therapeutic potential of T akeda‐ G ‐protein‐receptor‐5 ( TGR5 ) agonists. H ope or hype?
Hodge, R. J., & Nunez, D. J. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12636 · Cited by 63
Bourgot, C. L., Apper, E., Blat, S., & Respondek, F. (2018) · Nutrition & Metabolism · doi:10.1186/s12986-018-0245-3 · Cited by 67
Ao, M., Sarathy, J., Domingue, J., Alrefai, W. A., & Rao, M. C. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00416.2012 · Cited by 62
Xie, C., Jones, K. L., Rayner, C. K., & Wu, T. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090790 · Cited by 64
Knop, F. K. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00137.2010 · Cited by 63
Cummings, B. P., Bettaieb, A., Graham, J. L., Kim, J., Ma, F., Shibata, N. M., Stanhope, K. L., Giulivi, C., Hansen, F. B., Jelsing, J., et al. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.010421 · Cited by 65
Amplatz, B., Zöhrer, E., Haas, C., Schäffer, M., Stojaković, T., Jahnel, J., & Fauler, G. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.11.014 · Cited by 63
Yusta, B., Matthews, D., Flock, G. B., Ussher, J. R., Lavoie, B. A., Mawe, G. M., & Drucker, D. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.03.006 · Cited by 62
Chen, Y., Wu, S., & Tian, Y. (2017) · Laboratory Investigation · doi:10.1038/labinvest.2017.95 · Cited by 62
Bile acids and their effects on diabetes
Rajani, C., & Jia, W. P. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0644-x · Cited by 61
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Wang, C., Zhu, C., Shao, L., Ye, J., Shen, Y., & Ren, Y. (2019) · Mediators of Inflammation · doi:10.1155/2019/7659509 · Cited by 67
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Duarte-Silva, L., Gasaly, N., Poblete-Aro, C., Uribe, D., Echeverría, F., Gotteland, M., & García‐Díaz, D. F. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09622-0 · Cited by 67
Wang, T., Tao, S., Wu, Y., An, T., Lv, B., Liu, J.-X., Liu, Y.-T., & Jiang, G. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00329-22 · Cited by 66
Liu, T., Wang, J., Tong, Y., Wu, L., Xie, Y., He, P., Lin, S., & Hu, X. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04840-x · Cited by 65
Dysregulated bile acid homeostasis: unveiling its role in metabolic diseases
Wang, Y., Xu, H., Zhou, X., Chen, W., & Zhou, H. (2024) · Medical Review · doi:10.1515/mr-2024-0020 · Cited by 65
Molecular mechanisms underlying nutrient detection by incretin-secreting cells
Reimann, F. M. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.11.014 · Cited by 58
Zhang, Y., Jackson, J. P., Claire, R. L. S., Freeman, K., Brouwer, K. R., & Edwards, J. E. (2017) · Pharmacology Research & Perspectives · doi:10.1002/prp2.329 · Cited by 63
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Tang, T., Gong, T., Jiang, W., & Zhou, R. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.07.002 · Cited by 64
Martinou, E., Stefanova, I., Iosif, E., & Angelidi, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063339 · Cited by 64
Specific inhibition of bile acid transport alters plasma lipids and GLP-1
Rudling, M. J., Camilleri, M., Graffner, H., Holst, J. J., & Rikner, L. (2015) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0070-9 · Cited by 62
Burrin, D. G., Stoll, B., & Moore, D. D. (2013) · Journal of Animal Science · doi:10.2527/jas.2013-6331 · Cited by 61
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Jahnel, J., Zöhrer, E., Alisi, A., Ferrari, F., Ceccarelli, S., Vito, R. D., Scharnagl, H., Stojaković, T., Fauler, G., Trauner, M. A., et al. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000774 · Cited by 60
Jena, P. K., Sheng, L., Nagar, N., Wu, C., Barile, D., Mills, D. A., & Wan, Y.-J. Y. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.04.007 · Cited by 60
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Jena, P. K., Sheng, L., Li, Y., & Wan, Y.-J. Y. (2020) · HepatoBiliary Surgery and Nutrition · doi:10.21037/hbsn.2019.09.07 · Cited by 59
Sanduzzi‐Zamparelli, M., Compare, D., Coccoli, P., Rocco, A., Nardone, O. M., Marrone, G., Gasbarrini, A., Grieco, A., Nardone, G., & Miele, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081225 · Cited by 64
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Sheng, W., Ji, G., & Zhang, L. R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.910493 · Cited by 65
Metformin: A Dual-Role Player in Cancer Treatment and Prevention
Galal, M. A., Al-Rimawi, M., Hajeer, A., Dahman, H., Alouch, S. S., & Aljada, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074083 · Cited by 73
Giorgi, S. D., Campos, V. C., Egli, L., Toepel, U., Carrel, G., Cariou, B., Rainteau, D. P., Schneiter, P., Tappy, L., & Giusti, V. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.09.018 · Cited by 59
Andújar-Plata, P., Pi-Sunyer, X., & Laferrère, B. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.09.022 · Cited by 59
Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients
Sonne, D. P., Hare, K. J., Martens, P. C., Rehfeld, J. F., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00435.2012 · Cited by 58
Sun, W., Zhang, D., Wang, Z., Sun, J., Xu, B., Chen, Y., Ding, L., Huang, X., Lv, X., Lu, J., et al. (2016) · Medicine · doi:10.1097/md.0000000000002778 · Cited by 61
Obesity diabetes and the role of bile acids in metabolism
TOMKIN, G. H., & Owens, D. (2016) · Journal of Translational Internal Medicine · doi:10.1515/jtim-2016-0018 · Cited by 58
Treatment of Obesity in Mitigating Metabolic Risk
Heffron, S. P., Parham, J. S., Pendse, J., & Alemán, J. O. (2020) · Circulation Research · doi:10.1161/circresaha.119.315897 · Cited by 62
Bidault, V., Merlen, G., Glénisson, M., Doignon, I., Garcin, I., Pean, N., Boisgard, R., Bedoya, J. U., Sérino, M., Ullmer, C., et al. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100214 · Cited by 60
Lee, J. S., Han, P., Chaudhury, R., Khan, S. N., Bickerton, S., McHugh, M. D., Park, H. B., Siefert, A. L., Rea, G., Carballido, J. M., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00791-0 · Cited by 61
Cross-Talk Between Gut Microbiota and Adipose Tissues in Obesity and Related Metabolic Diseases
Wu, D., Wang, H., Xie, L., & Hu, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.908868 · Cited by 62
Pectin mediates the mechanism of host blood glucose regulation through intestinal flora
Guo, Q., Hou, X., Cui, Q., Li, S., Shen, G., Luo, Q., Wu, H., Chen, H., Liu, Y., Chen, A., et al. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2173719 · Cited by 63
Role of Intestinal Microbiome in Lipid and Glucose Metabolism in Diabetes Mellitus
van Olden, C. C., Groen, A. K., & Nieuwdorp, M. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.008 · Cited by 61
Roda, A., Pellicciari, R., Gioiello, A., Neri, F., Camborata, C., Passeri, D., Franco, F., Spinozzi, S., Colliva, C., Adorini, L., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.214650 · Cited by 59
Self-citationWang, Y., Li, J., Matye, D. J., Zhang, Y., Dennis, K. L., Ding, W., & Li, T. (2018) · JCI Insight · doi:10.1172/jci.insight.99676 · Cited by 57
Wang, X., Yang, J., Qiu, X., Wen, Q., Liu, M., Zhou, D., & Chen, Q. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.645035 · Cited by 60
Koopen, A. M., Witjes, J. J., Wortelboer, K., Majait, S., Prodan, A., Levin, E., Herrema, H., Winkelmeijer, M., Aalvink, S., Bergman, J. J. G. H. M., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323297 · Cited by 60
The role of bile acid receptor TGR5 in regulating inflammatory signalling
Ye, D., He, J., & He, X. (2024) · Scandinavian Journal of Immunology · doi:10.1111/sji.13361 · Cited by 61
Dietary Effects on Incretin Hormone Secretion
Wu, T., Rayner, C. K., Jones, K. L., & Horowitz, M. (2010) · Vitamins and hormones · doi:10.1016/b978-0-12-381517-0.00003-5 · Cited by 58
Sugita, T., Amano, K., Nakano, M., Masubuchi, N., Sugihara, M., & Matsuura, T. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/717431 · Cited by 55
Metadata
- Authors
- Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., Pellicciari, R., Auwerx, J., & Schoonjans, K.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Perugia (IT)
- Intercept Pharmaceuticals (United States) (US)
- Corresponding author
- Auwerx, Johan
- Schoonjans, Kristina
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 10
- Issue
- 3
- Pages
- 167-177
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC2739652
- OpenAlex
- W2081271380
- Cited by
- 1,885
- References
- 43
- Citations by year
- 2026: 143 · 2025: 100 · 2024: 153 · 2023: 112 · 2022: 135 · 2021: 141 · 2020: 148 · 2019: 113 · 2018: 124 · 2017: 126 · 2016: 106 · 2015: 108 · 2014: 87 · 2013: 91 · 2012: 69
- FWCI
- 47.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1415 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- European Commission
- Centre National de la Recherche Scientifique
- Australian Research Council
- National Institutes of Health
- Agence Nationale de la Recherche
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- TGR5, glucose homeostasis, glucagon-like peptide-1, enteroendocrine cells, energy expenditure, diet-induced obesity, diabesity, ATP/ADP ratio, calcium mobilization, brown adipose tissue, pancreatic function, liver function, TGR5 agonists, INT-777, incretin-based therapy
- MeSH terms
- Adenosine Triphosphate, Animals, Bile Acids and Salts, Calcium, Cell Line, Cholic Acids, Cricetulus, Glucose, Cricetinae, Homeostasis, Humans, Insulin, Male, Mice, Inbred C57BL, Mice, Obese, Oxidative Phosphorylation, Signal Transduction, CHO Cells, Mice, Knockout, Enteroendocrine Cells, Receptors, G-Protein-Coupled, Mice, Glucagon-Like Peptide 1
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