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TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Open accessAbstract
TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- and loss-of-function studies in vivo, we show here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice. In addition, we show that the induction of GLP-1 release in enteroendocrine cells by 6alpha-ethyl-23(S)-methyl-cholic acid (EMCA, INT-777), a specific TGR5 agonist, is linked to an increase of the intracellular ATP/ADP ratio and a subsequent rise in intracellular calcium mobilization. Altogether, these data show that the TGR5 signaling pathway is critical in regulating intestinal GLP-1 secretion in vivo, and suggest that pharmacological targeting of TGR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
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In the citing paper
“Bacteria-derived secondary bile acids (lithocholic acid, deoxycholic acid) can activate the G-protein coupled bile acid receptor Gpbar1 receptor (TGR5) in L cells, promoting the peripheral release of GLP-1 and PYY (Katsuma et al., 2005;Thomas et al., 2009;Ullmer et al., 2013).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Thomas et al., 2009
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In the citing paper
“Bile acids also increase energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin. This effect is dependent on induction of the type 2 iodothyronine deiodinase and is mediated by the binding of bile acids to a novel G-protein-coupled receptor TGR5 148.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
In the citing paper
“Bile acids induce insulin secretion directly via the transmembrane bile acid receptor Takeda G protein–coupled receptor 5 (on β cells and indirectly via stimulation of l-cell derived GLP-1 and subsequent insulin release (110–112).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [112]
In the citing paper
“TGR5 is therefore a new and attractive target for treating obesity, since it can theoretically protect against obesity and its complications via two distinct and potentially synergistic mechanisms: increased energy expenditure and improved insulin sensitivity 148.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
In the citing paper
“Bile acids also increase energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin. This effect is dependent on induction of the type 2 iodothyronine deiodinase and is mediated by the binding of bile acids to a novel G-protein-coupled receptor TGR5 148.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
In the citing paper
“One promising TGR5 agonist, INT-777, has already shown efficacy in vivo, increasing energy expenditure and reducing adiposity in mice with diet-induced obesity 148,149.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [148]
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Citations
Cites
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
Drucker, D. J., & Nauck, M. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69705-5 · Cited by 3,896
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
Self-citationThe biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
A G Protein-coupled Receptor Responsive to Bile Acids
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209706200 · Cited by 1,628
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
Hirasawa, A., Tsumaya, K., Awaji, T., Katsuma, S., Adachi, T., Yamada, M., Sugimoto, Y., Miyazaki, S., & Tsujimoto, G. (2004) · Nature Medicine · doi:10.1038/nm1168 · Cited by 1,580
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,425
Self-citationTargeting bile‐acid signalling for metabolic diseases
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J., & Schoonjans, K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2619 · Cited by 1,422 · cited 2×
“The complete absence of changes in the expression level of classical target genes of FXR in the liver, such as cholesterol 7a hydroxylase (CYP7A1) and bile salt export pump (BSEP) (Thomas et al., 2008), further confirmed the specificity of INT-777 toward TGR5 (Figure S6B).”
BackgroundSelf-citationIdentification of membrane-type receptor for bile acids (M-BAR)
Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H., & Tanaka, K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02550-0 · Cited by 993
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
Zhang, Y., Lee, F. Y., Barrera, G., Lee, H., Vales, C., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506982103 · Cited by 974
Cited by
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Items 201–300 of 999
Nonalcoholic Fatty Liver Disease Pandemic Fuels the Upsurge in Cardiovascular Diseases
Cai, J., Zhang, X., Ji, Y., Zhāng, P., She, Z., & Li, H. (2020) · Circulation Research · doi:10.1161/circresaha.119.316337 · Cited by 182
Intestinal microbiota and type 2 diabetes: From mechanism insights to therapeutic perspective
Han, J.-L., & Lin, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i47.17737 · Cited by 188
Resistant starch can improve insulin sensitivity independently of the gut microbiota
Bindels, L. B., Muñoz, R. R. S., Neto, J. C. G., Mutemberezi, V., Martínez, I., Salazar, N., Cody, E. A., Quintero, M., Kittana, H., Reyes‐Gavilán, C. G. D. L., et al. (2017) · Microbiome · doi:10.1186/s40168-017-0230-5 · Cited by 181
Shi, Y., Su, W., Zhang, L., Shi, C., Zhou, J., Wang, P., Wang, H., Shi, X., Wei, S., Wang, Q., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609060 · Cited by 177
Self-citationThe Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases
Fogelson, K. A., Dorrestein, P. C., Zarrinpar, A., & Knight, R. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.022 · Cited by 177
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
Flynn, C. R., Albaugh, V. L., Cai, S. B., Cheung‐Flynn, J., Williams, P. E., Brucker, R. M., Bordenstein, S. R., Guo, Y. P., Wasserman, D. H., & Abumrad, N. N. (2015) · Nature Communications · doi:10.1038/ncomms8715 · Cited by 185
The Role of the Gut Microbiota in the Pathogenesis of Diabetes
Bielka, W., Przezak, A., & Pawlik, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010480 · Cited by 189
Biology of Obesity: Lessons from Animal Models of Obesity
Kanasaki, K., & Koya, D. (2011) · BioMed Research International · doi:10.1155/2011/197636 · Cited by 189
Glucagon-Like Peptide-1: Glucose Homeostasis and Beyond
Cho, Y. M., Fujita, Y., & Kieffer, T. J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170315 · Cited by 178
Bahne, E., Sun, E. W. L., Young, R. L., Hansen, M., Sonne, D. P., Hansen, J. S., Rohde, U., Liou, A. P., Jackson, M. L., de Fontgalland, D., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.93936 · Cited by 173
Expanding role of gut microbiota in lipid metabolism
Ghazalpour, A., Cespedes, I., Bennett, B. J., & Allayee, H. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000278 · Cited by 177
Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery
Albaugh, V. L., Banan, B., Antoun, J., Xiong, Y., Guo, Y. P., Ping, J., Alikhan, M. M., Clements, B. A., Abumrad, N. N., & Flynn, C. R. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.11.017 · Cited by 178
Intestinal organoids for assessing nutrient transport, sensing and incretin secretion
Zietek, T., Rath, E., Haller, D., & Daniel, H. (2015) · Scientific Reports · doi:10.1038/srep16831 · Cited by 172
Sterol Regulation of Metabolism, Homeostasis, and Development
Wollam, J., & Antebi, A. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-081308-165917 · Cited by 172
Xiao, S., Liu, C., Chen, M., Zou, J., Zhang, Z., Cui, X., Jiang, S., Shang, E., Qian, D., & Duan, J. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10174-w · Cited by 167
Zheng, Z., & Wang, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775526 · Cited by 178
Novel opportunities for next-generation probiotics targeting metabolic syndrome
Cani, P. D., & Van Hul, M. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.006 · Cited by 167
Antibiotic effects on gut microbiota and metabolism are host dependent
Fujisaka, S., Ussar, S., Clish, C. B., Devkota, S., Dreyfuss, J. M., Sakaguchi, M., Soto, M., Konishi, M., Softic, S., Altındiş, E., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86674 · Cited by 171
Breton, J., Galmiche, M. C., & Déchelotte, P. (2022) · Microorganisms · doi:10.3390/microorganisms10020452 · Cited by 184
Kida, T., Tsubosaka, Y., Hori, M., Ozaki, H., & Murata, T. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301565 · Cited by 174
Beneficial Bile Acid Metabolism from Lactobacillus plantarum of Food Origin
Prete, R., Long, S. L., Gallardo, A. L., Gahan, C. G., Corsetti, A., & Joyce, S. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-58069-5 · Cited by 165
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Ahmad, N. N., Pfalzer, A., & Kaplan, L. M. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.38 · Cited by 163
Impact of Gut Microbiota on Obesity, Diabetes, and Cardiovascular Disease Risk
Miele, L., Giorgio, V., Alberelli, M. A., Candia, E. D., Gasbarrini, A., & Grieco, A. (2015) · Current Cardiology Reports · doi:10.1007/s11886-015-0671-z · Cited by 168
Brown adipose tissue and its therapeutic potential
Lidell, M. E., Betz, M. J., & Enerbäck, S. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12255 · Cited by 168
Free radicals and male reproduction.
Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154
Bile acids and their receptors
Martinot, E., Sèdes, L., Baptissart, M., Lobaccaro, J.-M., Caira, F., Beaudoin, C., & Volle, D. H. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.01.006 · Cited by 162
Visekruna, A., & Luu, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703218 · Cited by 170
Distinct metabolomic signatures are associated with longevity in humans
Cheng, S. C., Larson, M. G., McCabe, E. L., Murabito, J. M., Rhee, E. P., Ho, J. E., Jacques, P. F., Ghorbani, A., Magnusson, M., Souza, A. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7791 · Cited by 163
Mulherin, A. J., Oh, A., Kim, H., Grieco, A. J., Lauffer, L. M., & Brubaker, P. L. (2011) · Endocrinology · doi:10.1210/en.2011-1485 · Cited by 158
Cyphert, H. A., Ge, X., Kohan, A. B., Salati, L. M., Zhang, Y., & Hillgartner, F. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.375907 · Cited by 162
The Role of the Gut Microbiota in Lipid and Lipoprotein Metabolism
Yu, Y., Raka, F., & Adeli, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122227 · Cited by 166
Li, T., Ferrell, J. M., Boehme, S., & Chiang, J. Y. L. (2013) · Hepatology · doi:10.1002/hep.26427 · Cited by 163
Bile Acid Signaling in Liver Metabolism and Diseases
Li, T., & Chiang, J. Y. L. (2011) · Journal of Lipids · doi:10.1155/2012/754067 · Cited by 159
Wang, P., Yan, Z., Zhong, J., Chen, J., Ni, Y., Li, L., Ma, L., Zhao, Z., Liu, D., & Zhu, Z. (2012) · Diabetes · doi:10.2337/db11-1503 · Cited by 158
Clinical relevance of the bile acid receptor TGR5 in metabolism
van Nierop, F. S., Scheltema, M. J. V., Eggink, H. M., Pols, T. W. H., Sonne, D. P., Knop, F. K., & Soeters, M. R. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30155-3 · Cited by 163
Palau‐Rodriguez, M., Tulipani, S., Queipo‐Ortuño, M. I., Urpí-Sardà, M., Tinahones, F. J., & Andrés‐Lacueva, C. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01151 · Cited by 163
Understanding the role of the gut ecosystem in diabetes mellitus
Aw, W., & Fukuda, S. (2017) · Journal of Diabetes Investigation · doi:10.1111/jdi.12673 · Cited by 158
The gut microbiome and aquatic toxicology: An emerging concept for environmental health
Adamovský, O., Buerger, A. N., Wormington, A. M., Ector, N., Griffitt, R. J., Bisesi, J. H., & Martyniuk, C. J. (2018) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4249 · Cited by 165
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology
Perino, A., & Schoonjans, K. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.002 · Cited by 157
Self-citationColesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
Potthoff, M. J., Potts, A., He, T., Duarte, J. A. G., Taussig, R., Mangelsdorf, D. J., Kliewer, S. A., & Burgess, S. C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00400.2012 · Cited by 158
The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism
Mayneris‐Perxachs, J., Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00721-3 · Cited by 161
The role of thyroid hormone and brown adipose tissue in energy homoeostasis
Bianco, A. C., & McAninch, E. A. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70069-x · Cited by 154
Crosstalk between glucagon-like peptide 1 and gut microbiota in metabolic diseases
Zeng, Y., Wu, Y., Zhang, Q., & Xiao, X. (2023) · mBio · doi:10.1128/mbio.02032-23 · Cited by 180
Kohli, R., Kirby, M., Setchell, K. D. R., Jha, P., Klustaitis, K. M., Woollett, L. A., Pfluger, P. T., Balistreri, W. F., Tso, P., Jandacek, R. J., et al. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00221.2010 · Cited by 155
Central anorexigenic actions of bile acids are mediated by TGR5
Perino, A., Velázquez‐Villegas, L. A., Bresciani, N., Sun, Y., Huang, Q. D., Fénelon, V. S., Castellanos-Jankiewicz, A., Zizzari, P., Bruschetta, G., Jin, S., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00398-4 · Cited by 159
Self-citationThe human microbiome and bile acid metabolism: Dysbiosis, dysmetabolism, disease and intervention
Jones, M. L., Martoni, C. J., Ganopolsky, J. G., Labbé, A., & Prakash, S. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2014.880420 · Cited by 150
The role of bile acids in metabolic regulation
Vítek, L., & Haluzík, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0469 · Cited by 157
The gut microbiome and cardiovascular disease: current knowledge and clinical potential
Ahmad, A. F., Dwivedi, G., O’Gara, F., Caparros-Martin, J. A., & Ward, N. C. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00376.2019 · Cited by 165
Nimer, N. A., Choucair, I., Wang, Z., Nemet, I., Li, L., Gukasyan, J., Weeks, T. L., Alkhouri, N., Zein, N. N., Tang, W. H. W., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154457 · Cited by 155
Bile acids and bariatric surgery
Albaugh, V. L., Banan, B., Ajouz, H., Abumrad, N. N., & Flynn, C. R. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.04.001 · Cited by 148
Targeted nanoparticles with novel non-peptidic ligands for oral delivery
Rieux, A. D., Pourcelle, V., Cani, P. D., Marchand‐Brynaert, J., & Véronique Préat, A. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.01.002 · Cited by 149
Hepatic glucose sensing is required to preserve β cell glucose competence
Seyer, P., Vallois, D., Poitry‐Yamate, C., Schütz, F., Metref, S., Tarussio, D., Maechler, P., Staels, B., Lanz, B., Rolf Gruetter, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65538 · Cited by 165
Pathophysiological role of host microbiota in the development of obesity
Kobyliak, N. M., Virchenko, O., & Falalyeyeva, T. M. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0166-9 · Cited by 156
Donepudi, A. C., Boehme, S., Li, F., & Chiang, J. Y. L. (2016) · Hepatology · doi:10.1002/hep.28707 · Cited by 146
Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
Chaudhari, S. N., Harris, D. A., Aliakbarian, H., Luo, J. N., Henke, M. T., Subramaniam, R., Vernon, A. H., Tavakkoli, A., Sheu, E. G., & Devlin, A. S. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0604-z · Cited by 150
Labbé, A., Ganopolsky, J. G., Martoni, C., Prakash, S., & Jones, M. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115175 · Cited by 149
Simonen, M., Dali-Youcef, N., Kaminska, D., Venesmaa, S., Käkelä, P., Pääkkönen, M., Hallikainen, M., Kolehmainen, M., Uusitupa, M., Moilanen, L., et al. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0673-5 · Cited by 145
Self-citationBile acids: a communication channel in the gut-brain axis
Monteiro-Cardoso, V. F., Corlianò, M., & Singaraja, R. R. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-020-08625-z · Cited by 145
Unravelling the involvement of gut microbiota in type 2 diabetes mellitus
Arora, A., Behl, T., Sehgal, A., Singh, S., Sharma, N., Bhatia, S., Sobarzo‐Sánchez, E., & BUNGAU, S. G. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119311 · Cited by 147
Masyuk, A. I., Huang, B. Q., Radtke, B. N., Gajdos, G. B., Splinter, P. L., Masyuk, T. V., Gradilone, S. A., & LaRusso, N. F. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00383.2012 · Cited by 143
Intrahepatic cholestasis of pregnancy is associated with an increased risk of gestational diabetes
Martineau, M., Raker, C., Powrie, R. O., & Williamson, C. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.12.037 · Cited by 143
The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Chow, M. D., Lee, Y., & Guo, G. L. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.04.004 · Cited by 143
Yahoo, N., Dudek, M., Knolle, P. A., & Heikenwälder, M. F. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.033 · Cited by 147
Effect of different bile acids on the intestine through enterohepatic circulation based on FXR
Xiang, J., Zhang, Z., Xie, H., Zhang, C., Bai, Y., Cao, H., Che, Q., Guo, J., & Su, Z. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1949095 · Cited by 146
Understanding bile acid signaling in diabetes: From pathophysiology to therapeutic targets
Ferrell, J. M., & Chiang, J. Y. L. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0043 · Cited by 139
Gut microbiota-derived metabolites tune host homeostasis fate
Kim, S., Seo, S., & Kweon, M. (2024) · Seminars in Immunopathology · doi:10.1007/s00281-024-01012-x · Cited by 156
Metabolism of hydrogen gases and bile acids in the gut microbiome
Hylemon, P. B., Harris, S. C., & Ridlon, J. M. (2018) · FEBS Letters · doi:10.1002/1873-3468.13064 · Cited by 140
Bile acid-activated receptors in the treatment of dyslipidemia and related disorders
Fiorucci, S., Cipriani, S., Baldelli, F., & Mencarelli, A. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.11.001 · Cited by 142
Bile acids: short and long term effects in the intestine
Bajor, A., Gillberg, P., & Abrahamsson, H. (2010) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521003702734 · Cited by 142
The Whitening of Brown Fat and Its Implications for Weight Management in Obesity
Shimizu, I., & Walsh, K. X. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0157-8 · Cited by 141
Bile acid receptors in non-alcoholic fatty liver disease
Li, Y., Jadhav, K. S., & Zhang, Y. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.08.015 · Cited by 140
Obesity and microbiota: an example of an intricate relationship
Duranti, S., Ferrario, C., van Sinderen, D., Ventura, M., & Turroni, F. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0566-2 · Cited by 148
Baars, A., Oosting, A., Knol, J., Garssen, J., & Van Bergenhenegouwen, J. (2015) · Microorganisms · doi:10.3390/microorganisms3040641 · Cited by 135
Jena, P. K., Sheng, L., Di Lucente, J., Jin, L., Maezawa, I., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201700984rr · Cited by 134
Chen, J., Li, Y., Tian, Y., Huang, C., Li, D., Zhong, Q., & Ma, X. (2015) · Current Protein and Peptide Science · doi:10.2174/1389203716666150630135720 · Cited by 135
Hanafi, N. I., Mohamed, A. S., Kadir, S. H. S. A., & Othman, M. H. D. (2018) · Biomolecules · doi:10.3390/biom8040159 · Cited by 140
Bailey, M., Naik, N. C., Wild, L. E., Patterson, W. B., & Alderete, T. L. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1749754 · Cited by 137
Wang, T., Han, J., Dai, H., Sun, J., Ren, J., Wang, W., Qiao, S., Liu, C., Sun, L., Liu, S., et al. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119862 · Cited by 139
Wong, B. S., Camilleri, M., McKinzie, S., Burton, D., Graffner, H., & Zinsmeister, A. R. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.285 · Cited by 133
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133
Đanić, M., Stanimirov, B., Pavlović, N., Goločorbin-Kon, S., Al‐Salami, H., Stankov, K., & Mikov, M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01382 · Cited by 135
Xu, L., Zhang, Y., Li, X., Li, C., Hu, H., Hu, J., Liu, M., Yang, Q. Z., Gu, P., Li, J., et al. (2025) · iMeta · doi:10.1002/imt2.270 · Cited by 143
Martineau, M., Raker, C., Dixon, P. H., Chambers, J., Machirori, M., King, N. M., Hooks, M. L., Manoharan, R., Chen, K. S.-M., Powrie, R. O., et al. (2014) · Diabetes Care · doi:10.2337/dc14-2143 · Cited by 131
Pols, T. W. H., Puchner, T., Korkmaz, H. I., Vos, M., Soeters, M. R., & de Vries, C. J. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176715 · Cited by 138
Bile acid receptors and gastrointestinal functions
Ticho, A. L., Malhotra, P., Dudeja, P. K., Gill, R. K., & Alrefai, W. A. (2019) · Liver Research · doi:10.1016/j.livres.2019.01.001 · Cited by 138
Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
Wang, H., Wang, J., Cui, H., Fan, C., Xue, Y., Liu, H., Li, H., Li, J., Li, H., Sun, Y., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01036-5 · Cited by 136
Wewalka, M., Patti, M., Barbato, C., Houten, S. M., & Goldfine, A. B. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3367 · Cited by 135
Lavoie, B. A., Balemba, O. B., Godfrey, C. B., Watson, C. A., Vassileva, G., Corvera, C. U., Nelson, M. T., & Mawe, G. M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.192146 · Cited by 133
Genetic and microbiome influence on lipid metabolism and dyslipidemia
Matey-Hernandez, M. L., Williams, F. M. K., Potter, T. I. T., Valdes, A. M., Spector, T. D., & Menni, C. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00053.2017 · Cited by 134
Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-Associated Diseases
Tu, P., Chi, L., Bodnar, W. M., Zhang, Z., Gao, B., Bian, X., Stewart, J. R., Fry, R. C., & Lü, K. (2020) · Toxics · doi:10.3390/toxics8010019 · Cited by 136
Makki, K., Brolin, H., Petersen, N., Henricsson, M., Christensen, D. P., Khan, M. T., Wahlstrom, A. M., Bergh, P., Tremaroli, V., Schoonjans, K., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-326541 · Cited by 136
Self-citationCombined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis
Anakk, S., 渡辺, 光., Ochsner, S. A., McKenna, N. J., Finegold, M. J., & Moore, D. D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42846 · Cited by 131
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Hov, J. R., Keitel, V., Laerdahl, J. K., Spomer, L., Ellinghaus, E., ElSharawy, A., Melum, E., Boberg, K. M., Manke, T., Balschun, T. C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012403 · Cited by 137
Man, A. W. C., Zhou, Y., Xia, N., & Li, H. (2020) · Nutrients · doi:10.3390/nu12103054 · Cited by 138
Loss of Cyp8b1 Improves Glucose Homeostasis by Increasing GLP-1
Kaur, A., Patankar, J. V., de Haan, W., Ruddle, P., Wijesekara, N., Groen, A. K., Verchere, C. B., Singaraja, R. R., & Hayden, M. R. (2014) · Diabetes · doi:10.2337/db14-0716 · Cited by 124
Sheng, L., Jena, P. K., Liu, H., Hu, Y. C., Nagar, N., Bronner, D. N., Settles, M. L., Bäumler, A. J., & Wan, Y. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201800370r · Cited by 129
Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy
Lin, B., Wang, Y., Zhang, P., Yuan, Y., Zhang, Y., & Chen, G. (2020) · The Journal of Headache and Pain · doi:10.1186/s10194-020-01170-x · Cited by 137
Pushpass, R.-A. G., Alzoufairi, S., Jackson, K. G., & Lovegrove, J. A. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000081 · Cited by 136
Döring, B., Lütteke, T., Geyer, J., & Petzinger, E. (2012) · Current topics in membranes · doi:10.1016/b978-0-12-394316-3.00004-1 · Cited by 131
Metadata
- Authors
- Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M., Pellicciari, R., Auwerx, J., & Schoonjans, K.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Perugia (IT)
- Intercept Pharmaceuticals (United States) (US)
- Corresponding author
- Auwerx, Johan
- Schoonjans, Kristina
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 10
- Issue
- 3
- Pages
- 167-177
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC2739652
- OpenAlex
- W2081271380
- Cited by
- 1,885
- References
- 43
- Citations by year
- 2026: 143 · 2025: 100 · 2024: 153 · 2023: 112 · 2022: 135 · 2021: 141 · 2020: 148 · 2019: 113 · 2018: 124 · 2017: 126 · 2016: 106 · 2015: 108 · 2014: 87 · 2013: 91 · 2012: 69
- FWCI
- 47.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1415 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- European Commission
- Centre National de la Recherche Scientifique
- Australian Research Council
- National Institutes of Health
- Agence Nationale de la Recherche
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Keywords
- TGR5, glucose homeostasis, glucagon-like peptide-1, enteroendocrine cells, energy expenditure, diet-induced obesity, diabesity, ATP/ADP ratio, calcium mobilization, brown adipose tissue, pancreatic function, liver function, TGR5 agonists, INT-777, incretin-based therapy
- MeSH terms
- Adenosine Triphosphate, Animals, Bile Acids and Salts, Calcium, Cell Line, Cholic Acids, Cricetulus, Glucose, Cricetinae, Homeostasis, Humans, Insulin, Male, Mice, Inbred C57BL, Mice, Obese, Oxidative Phosphorylation, Signal Transduction, CHO Cells, Mice, Knockout, Enteroendocrine Cells, Receptors, G-Protein-Coupled, Mice, Glucagon-Like Peptide 1
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