The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice
Open accessAbstract
Summary To determine whether insulin action on endothelial cells promotes or protects against atherosclerosis, we generated apolipoprotein E null mice in which the insulin receptor gene was intact or conditionally deleted in vascular endothelial cells. Insulin sensitivity, glucose tolerance, plasma lipids, and blood pressure were not different between the two groups, but atherosclerotic lesion size was more than 2-fold higher in mice lacking endothelial insulin signaling. Endothelium-dependent vasodilation was impaired and endothelial cell VCAM-1 expression was increased in these animals. Adhesion of mononuclear cells to endothelium in vivo was increased 4-fold compared with controls, but reduced to below control values by a VCAM-1 blocking antibody. These results provide definitive evidence that loss of insulin signaling in endothelium, in the absence of competing systemic risk factors, accelerates atherosclerosis. Therefore, improving insulin sensitivity in the endothelium of patients with insulin resistance or type 2 diabetes may prevent cardiovascular complications.
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Cites
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“, 1999) and blunted vascular effects of insulin (Steinberg et al., 1996).”
BackgroundResultInfluentialTie2-Cre Transgenic Mice: A New Model for Endothelial Cell-Lineage Analysis in Vivo
Kisanuki, Y. Y., Hammer, R. E., Miyazaki, J.-I., Williams, S. C., Richardson, J. A., & Yanagisawa, M. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0106 · Cited by 1,241
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Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604 · cited 6×
“Multiple studies have shown that systemic insulin resistance is associated with impaired vascular insulin signaling (Jiang et al., 1999) and blunted vascular effects of insulin (Steinberg et al.”
BackgroundResultInfluentialSelf-citationDrummond, G. R., Cai, H., Davis, M. E., Ramasamy, S., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.86.3.347 · Cited by 430
Expression of Tie-2 by Human Monocytes and Their Responses to Angiopoietin-2
Murdoch, C., Tazzyman, S., Webster, S., & Lewis, C. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7405 · Cited by 318
Insulin Stimulates Both Endothelin and Nitric Oxide Activity in the Human Forearm
Cardillo, C., Nambi, S. S., Kilcoyne, C. M., Choucair, W. K., Katz, A., Quon, M. J., & Panza, J. A. (1999) · Circulation · doi:10.1161/01.cir.100.8.820 · Cited by 301
Cited by
Low Wang, C. C., Hess, C. N., Hiatt, W. R., & Goldfine, A. B. (2016) · Circulation · doi:10.1161/circulationaha.116.022194 · Cited by 1,155
Vascular Complications of Diabetes: Mechanisms of Injury and Protective Factors
Rask-Madsen, C., & King, G. L. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.012 · Cited by 846
Self-citationGuo, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0327 · Cited by 623
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 572
Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents
Di Pino, A., & DeFronzo, R. A. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00141 · Cited by 535
Metadata
- Authors
- Rask-Madsen, C., Li, Q., Freund, B., Feather, D., Abramov, R., Wu, I.-H., Chen, K., Yamamoto-Hiraoka, J., Goldenbogen, J., Sotiropoulos, K. B., Clermont, A., Geraldes, P., Dall'Osso, C., Wagers, A. J., Huang, P. L., Rekhter, M., Scalia, R., Kahn, C. R., & King, G. L.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 11
- Issue
- 5
- Pages
- 379-389
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2071251286
- Cited by
- 303
- References
- 7
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Rask-Madsen, C., Li, Q., Freund, B., Feather, D., Abramov, R., Wu, I.-H., Chen, K., Yamamoto-Hiraoka, J., Goldenbogen, J., Sotiropoulos, K. B., Clermont, A., Geraldes, P., Dall'Osso, C., Wagers, A. J., Huang, P. L., Rekhter, M., Scalia, R., Kahn, C. R., & King, G. L. (2010). Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice. Cell Metabolism. https://doi.org/10.1016/j.cmet.2010.03.013
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
