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Cited by 572

The DOI matches its Crossref record; 640 of the 640 references it cites were found in a registry or an index.

Endothelial Cell Metabolism

Open access
Eelen, Guy, de Zeeuw, Pauline, Treps, Lucas, Harjes, Ulrike, Wong, Brian W., Carmeliet, Peter·2018·Physiological Reviews
DOI 10.1152/physrev.00001.2017
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Abstract

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are active players in the formation of new blood vessels (angiogenesis) both in health and (life-threatening) diseases. Recently, a new concept arose by which EC metabolism drives angiogenesis in parallel to well-established angiogenic growth factors (e.g., vascular endothelial growth factor). 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3-driven glycolysis generates energy to sustain competitive behavior of the ECs at the tip of a growing vessel sprout, whereas carnitine palmitoyltransferase 1a-controlled fatty acid oxidation regulates nucleotide synthesis and proliferation of ECs in the stalk of the sprout. To maintain vascular homeostasis, ECs rely on an intricate metabolic wiring characterized by intracellular compartmentalization, use metabolites for epigenetic regulation of EC subtype differentiation, crosstalk through metabolite release with other cell types, and exhibit EC subtype-specific metabolic traits. Importantly, maladaptation of EC metabolism contributes to vascular disorders, through EC dysfunction or excess angiogenesis, and presents new opportunities for anti-angiogenic strategies. Here we provide a comprehensive overview of established as well as newly uncovered aspects of EC metabolism.

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Crossref · 10.1152/physrev.00001.2017

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Citations

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Metadata

Authors
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2018-01-01
Volume
98
Issue
1
Pages
3-58
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00001.2017
OpenAlex
W2768787879
Cited by
572
References
640
FWCI
2.27
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Endothelial Cell Metabolism. https://app.cochat.ai/papers/10.1152/physrev.00001.2017
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Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018). Endothelial Cell Metabolism. Physiological Reviews. https://doi.org/10.1152/physrev.00001.2017

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.