PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation

Upstream and downstream of mTOR

Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293

Regulation of protein kinase cascades by protein phosphatase 2A

Millward, T. A., Zołnierowicz, S., & Hemmings, B. A. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01375-4 · Cited by 793

Nutrient-Dependent Expression of Insulin-like Peptides from Neuroendocrine Cells in the CNS Contributes to Growth Regulation in Drosophila

Ikeya, T., Galic, M., Belawat, P., Nairz, K., & Hafen, E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01043-6 · Cited by 765

Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathwayPreprint

Puig, Ó., Marr, M. T., Ruhf, M.-L., & Tjian, R. (2003) · Genes & Development · doi:10.1101/gad.1098703 · Cited by 628

mTOR, translation initiation and cancer

Mamane, Y., Petroulakis, E., LeBacquer, O., & Sonenberg, N. (2006) · Oncogene · doi:10.1038/sj.onc.1209888 · Cited by 607

Ends-out, or replacement, gene targeting in Drosophila

Gong, W. J., & Golic, K. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0535280100 · Cited by 363

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

Taguchi, A., & White, M. F. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100533 · Cited by 319

PP2A: Unveiling a Reluctant Tumor Suppressor

Mumby, M. (2007) · Cell · doi:10.1016/j.cell.2007.06.034 · Cited by 295

Protein Phosphatase 2A with B′ specificity subunits regulates the Hippo-Yorkie signaling axis in the Drosophila eye disc

Neal, S. J., Zhou, Q., & Pignoni, F. (2022) · Journal of Cell Science · doi:10.1242/jcs.259558 · Cited by 6

Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity

Sim, J. P. L., Wang, Z., Basil, A. H., Lin, S., Chen, Z., Zhang, C., Zeng, L., Cai, Y., & Lim, K. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08577-z · Cited by 6

S6 Kinase: A Compelling Prospect for Therapeutic Interventions

Majeed, S. T., Majeed, R., Shah, G., & Andrabi, K. I. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.75209 · Cited by 5

Remote control of AMPK via extracellular adenosine controls tissue growth

Zhang, Y., Straßburger, K., & Teleman, A. A. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01764-0 · Cited by 4

Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1.

Nada, S., & Okada, M. (2020) · Journal of Biochemistry (Tokyo) · doi:10.1093/jb/mvaa076 · Cited by 2

A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1

Palu, R. A. S., Owings, K. G., Garces, J. G., & Nicol, A. (2022) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkac090 · Cited by 3

Sch9S6K controls DNA repair and DNA damage response efficiency in aging cells

Lucca, C., Ferrari, E., Shubassi, G., Ajazi, A., Choudhary, R., Bruhn, C., Matafora, V., Bachi, A., & Foiani, M. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114281 · Cited by 3

Functional Roles of a Putative B' Delta Regulatory Subunit and a Catalytic Subunit of Protein Phosphatase 2A in the Cereal Pathogen Fusarium graminearum

Kim, H.-K., & Yun, S. (2012) · The Plant Pathology Journal · doi:10.5423/ppj.oa.05.2012.0059 · Cited by 3

Spatiotemporal Crosstalk Between Oocyte and the Microenvironment Governs Preovulatory Follicle Aging

Koh, X. Y., Tan, K. J., Lim, Z. H., Ong, S. C., Tan, S. E., Lu, J. X., Huang, Z., & Pek, J. W. (2025) · Aging Cell · doi:10.1111/acel.70302 · Cited by 2

Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells

He, B., Wang, Z., & Moreau, R. F. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109087 · Cited by 2

Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction

Nakamura, T., Nada, S., Matsumoto, M., Othman, N. L., Kosako, H., Ikeda, K., Koshikawa, N., Masumoto, J., Sawasaki, T., Takekawa, M., et al. (2025) · Life Science Alliance · doi:10.26508/lsa.202503206 · Cited by 1

Fatty acid synthesis supports tumor progression through facilitating the activity of TORC1 signaling

Károlyi, D., Botor, B. S., Neuhauser, N., Rubics, A., Szinyákovics, J., Kovács, T., Péter, M., Balogh, G. E., O’Farrell, F., & Takáts, S. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08738-6 · Cited by 1

Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson’s disease

Athanasopoulos, P. S., Memou, A., Ho, F. Y., Soliman, A., Pots, H., Papadopoulou, V., von Zweydorf, F., Sriraman, S., Thouin, A. M., Vandewynckel, L., et al. (2026) · Biochemical Journal · doi:10.1042/bcj20260194 · Cited by 1

The nuts‐and‐bolts of ribosomal protein s6 kinase 1 regulation: A shared responsibility for mTOR complexes 1 and 2

Majeed, S. T., Majeed, R., & Andrabi, K. I. (2026) · FEBS Journal · doi:10.1111/febs.70612 · Cited by 1

Royal jelly attenuates metabolic defects in a drosophila mutant with elevated TORC1 activity

Yang, C., Cai, J., Fu, Y., Feng, C., Hao, Y., & Wei, Y. (2020) · Biology Open · doi:10.1242/bio.054999 · Cited by 1

Sorting & Sequencing Flies by Size: Identification of novel TOR regulators and Parameters for Successful SortingPreprint

Straßburger, K., Zöller, T., Sandmann, T., Leible, S., Kerr, G., Boutros, M., & Teleman, A. A. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/119719 · Cited by 1

Lysosomal cystine mobilization shapes the response of mTORC1 and tissue growth to fastingPreprint

Jouandin, P., Marelja, Z., Parkhitko, A. A., Dambowsky, M., Asara, J. M., Nemazanyy, I., Dibble, C. C., Simons, M., & Perrimon, N. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/606541 · Cited by 1

Autonomous termination of proliferation in the Drosophila wing disc is TORC1 dependentPreprint

Straßburger, K., Lutz, M., Müller, S., & Teleman, A. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.11.420828 · Cited by 1

Cytoplasmic zinc regulates IL-1β production by monocytes/macrophages via mTORC1-induced glycolysis in rheumatoid arthritis (RA)Preprint

Kim, B., Kim, H. Y., Yoon, B. R., Yeo, J., Yu, K., Kim, H. C., Park, J. K., Kang, S. W., & Lee, W. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.16.437150 · Cited by 1

Genome wide analysis for novel regulators of growth and lipid metabolism in drosophila melanogaster

Zahoor, M. K. (2011) · doi:10.70675/2aaefe56z4d41z41a4z9a06z73986424911d · Cited by 1

Understanding the Mechanism by which Metabolism of Monomethyl Branched-Chain Fatty Acids Impact C. elegans Development

Wang, R. (2014) · CU Scholar (University of Colorado Boulder)

Multiple pools of Protein Phosphatase 2A-B56 function to antagonize spindle assembly, promote kinetochore attachments and maintain cohesion in Drosophila OocytesPreprint

Jang, J. K., Gladstein, A. C., Das, A., Sisco, Z. L., & McKim, K. S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.01.232512

A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1Preprint

Owings, K. G., & Palu, R. A. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.13.460173

Caracterização da interação da proteína TIPRL com fosfatases tipo 2A em cultura de células

Iacia, A. A. S. (2021) · doi:10.47749/t/unicamp.2021.1168870

Additional file 1 of The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

Hsiao, K.-C., Ruan, S.-Y., Chen, S.-M., Lai, T.-Y., Chan, R.-H., Zhang, Y.-M., Chu, C.-A., Cheng, H.-C., Tsai, H.-W., Tu, Y.-F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23658369

Additional file 2 of The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

Hsiao, K.-C., Ruan, S.-Y., Chen, S.-M., Lai, T.-Y., Chan, R.-H., Zhang, Y.-M., Chu, C.-A., Cheng, H.-C., Tsai, H.-W., Tu, Y.-F., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23658372

Additional file 1 of Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster

Venugopal, P., Veyssière, H., Couderc, J., Richard, G., Vachias, C., & Mirouse, V. (2020) · Figshare · doi:10.6084/m9.figshare.12502751

Propriétés signalétiques des B-arrestines : mise en évidence de nouveaux partenaires et implications fonctionnelles

Landomiel, F. (2015) · theses.fr (ABES) · doi:10.70675/140dba1fz2ba0z4eaaz9f32z9003cc60ebc5

Le traductome induit par le récepteur FSH et l'implication des B-arrestines dans le contrôle de la traduction des ARNm 5' TOP

Trefier, A. (2017) · theses.fr (ABES) · doi:10.70675/f653c589za0f2z437dz8bcaze158659883d0

Cerebral Cortical-Like Organoid Model of PPP2R5D Induced Genetic Intellectual Disability Displays Variant-Specific Disease Severity PhenotypePreprint

Du, Y., Singh, M., Patil, M. M., Villegas, I. J., Portillo, A., Shang, K., Ben‐Shalom, R., Halmai, J. A. N. M., & Fink, K. D. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.26.728012

Drosophila storage proteins promote both the rate and the duration of tumor growth

Valzania, L., Blanco-Obregon, D., Alami, A., & Léopold, P. (2026) · Science Advances · doi:10.1126/sciadv.aeb2956

InAKTivation of insulin/IGF-1 signaling by dephosphorylation

Narasimhan, S. D., Mukhopadhyay, A., & Tissenbaum, H. A. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10072 · Cited by 19

Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase

Bielinski, V. A., & Mumby, M. C. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.05.008 · Cited by 38

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G. J., Czech, M., & Tissenbaum, H. A. (2009) · Cell · doi:10.1016/j.cell.2009.01.025 · Cited by 170

ACCELERATED PUBLICATION Insulin-induced Drosophila S6 kinase activation requires phosphoinositide

(2015)

Phosphatase PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis

Cheng, Y.-S. (2015) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00018759