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Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

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Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

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New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

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Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

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Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP

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Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

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Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth

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RNA polymerase III limits longevity downstream of TORC1

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Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification

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REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1

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PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer

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PHLPP-Mediated Dephosphorylation of S6K1 Inhibits Protein Translation and Cell Growth

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Beyond controlling cell size: functional analyses of S6K in tumorigenesis

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Insulin Signaling Regulates Fatty Acid Catabolism at the Level of CoA Activation

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Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling

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Control of mTORC1 signaling by the Opitz syndrome protein MID1

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Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State

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An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling

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Mitf is a master regulator of the v-ATPase forming an Mitf/v-ATPase/TORC1 control module for cellular homeostasis

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Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting

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TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila

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The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function

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An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease

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Tissue-Specific Coupling between Insulin/IGF and TORC1 Signaling via PRAS40 in Drosophila

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EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy

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PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury

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Cytoplasmic zinc promotes IL-1β production by monocytes and macrophages through mTORC1-induced glycolysis in rheumatoid arthritis

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PP2A regulates autophagy in two alternative ways in Drosophila

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The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila

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Notch-1 signaling activates NF-κB in human breast carcinoma MDA-MB-231 cells via PP2A-dependent AKT pathway

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The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling

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Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo

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Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options

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Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

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PPP2R5C couples hepatic glucose and lipid homeostasis

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Microcystin-LR promotes proliferation by activating Akt/S6K1 pathway and disordering apoptosis and cell cycle associated proteins phosphorylation in HL7702 cells

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Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction

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Microcystin-LR promotes cell proliferation in the mice liver by activating Akt and p38/ERK/JNK cascades

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Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye

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TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1

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MicroRNA-652 induces NED in LNCaP and EMT in PC3 prostate cancer cells

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An overview of resistance to Human epidermal growth factor receptor 2 (Her2) targeted therapies in breast cancer

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Conservation of gene and tissue networks regulating insulin signalling in flies and vertebrates

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How it all Started: Tau and Protein Phosphatase 2A

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The protein phosphatase 2A B56γ regulatory subunit is required for heart development

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G protein‐dependent signaling triggers a β‐arrestin‐scaffolded p70S6K/ rpS6 module that controls 5'TOP mRNA translation

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Ecdysone regulates Drosophila wing disc size via a TORC1 dependent mechanism

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TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity

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eIF4A inactivates TORC1 in response to amino acid starvation

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The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster

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Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models

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Amino acid-induced impairment of insulin sensitivity in healthy and obese rats is reversible

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Divergent functions for eIF4E and S6 kinase by sonic hedgehog mitogenic signaling in the developing cerebellum

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Phosphoprotein Phosphatase PP2A Regulation of Insulin Receptor Substrate 1 and Insulin Metabolic Signaling

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TWEAK prevents TNF-α-induced insulin resistance through PP2A activation in human adipocytes

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Network‐regulated organ allometry: The developmental regulation of morphological scaling

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Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity

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Regulation and role of the PP2A-B56 holoenzyme family in cancer

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REPTOR and CREBRF encode key regulators of muscle energy metabolism

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The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

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Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest

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Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Zhao, Q., Liu, Y., Zhang, S., Zhao, Y., Wang, C., Li, K., Jin, Z., Qiao, J., & Liu, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.870326 · Cited by 23

The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma

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Has gene duplication impacted the evolution of Eutherian longevity?

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Ubiquitination and degradation of the hominoid-specific oncoprotein TBC1D3 is regulated by protein palmitoylation

Chen, K., Lange, J. J., Samovski, D., Su, X., Liu, J., Sundaresan, S., & Stahl, P. D. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.04.001 · Cited by 21

Cell type-specific control of protein synthesis and proliferation by FGF-dependent signaling to the translation repressor 4E-BP

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Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila

Fischer, P., Rosa, M. K. L., Schulz, A., Preiss, A., & Nagel, A. C. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005440 · Cited by 20

Ubiquitination and Degradation of the Hominoid-Specific Oncoprotein TBC1D3 Is Mediated by CUL7 E3 Ligase

Chen, K., Samovski, D., Srikanth, P., Wainszelbaum, M. J., Charron, A. J., Liu, J., Lange, J. J., Chen, P.-I., Pan, Z., Su, X., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046485 · Cited by 20

Absence of γ-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle

Moorwood, C., Philippou, Α., Spinazzola, J. M., Keyser, B., Macarak, E. J., & Barton, E. R. (2014) · Skeletal Muscle · doi:10.1186/2044-5040-4-13 · Cited by 20

Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation

Gollowitzer, A., Pein, H., Rao, Z., Waltl, L., Bereuter, L., Loeser, K., Meyer, T., Jafari, V., Witt, F., Winkler, R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56711-2 · Cited by 21

Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs

Straßburger, K., Lorbeer, F. K., Lutz, M., Graf, F., Boutros, M., & Teleman, A. A. (2017) · Development · doi:10.1242/dev.147538 · Cited by 19

SRC inhibition enables formation of a growth suppressive MAGI1-PP2A complex in isocitrate dehydrogenase-mutant cholangiocarcinoma

Luk, I. S. U., Bridgwater, C. M., Yu, A. Y. C., Boila, L. D., Yáñez-Bartolomé, M., Lampano, A., Hulahan, T. S., Boukhali, M., Kathiresan, M., Macarulla, T. M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adj7685 · Cited by 19

Multiple pools of PP2A regulate spindle assembly, kinetochore attachments and cohesion in Drosophila oocytes

Jang, J. K., Gladstein, A. C., Das, A., Shapiro, J. G., Sisco, Z., & McKim, K. S. (2021) · Journal of Cell Science · doi:10.1242/jcs.254037 · Cited by 18

Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila

Sun, D., & Buttitta, L. (2015) · Development · doi:10.1242/dev.120824 · Cited by 19

Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance

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Serine-threonine protein phosphatases: Lost in translation

KOLUPAEVA, V. G. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.08.006 · Cited by 18

Protein Phosphatase 2A: Role in T Cells and Diseases

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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila

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Combining affinity proteomics and network context to identify new phosphatase substrates and adapters in growth pathways

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A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism inDrosophila

Fischer, P., Preiss, A., & Nagel, A. C. (2016) · Fly · doi:10.1080/19336934.2016.1162362 · Cited by 14

ELK1/MTOR/S6K1 Pathway Contributes to Acquired Resistance to Gefitinib in Non-Small Cell Lung Cancer

Zhao, L., Wang, Y., Sun, X., Zhang, X., Simone, N. L., & He, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042382 · Cited by 12

Fat body glycolysis defects inhibit mTOR and promote distant muscle disorganization through TNF-α/egr and ImpL2 signaling in Drosophila larvae

Rodríguez-Vázquez, M., Falconi, J., Héron‐Milhavet, L., Lassus, P., Géminard, C., & Djiane, A. (2024) · EMBO Reports · doi:10.1038/s44319-024-00241-3 · Cited by 13

A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts

Jäger, K., Mensch, J., Grimmig, M., Neuner, B., Gorzelniak, K., Türkmen, S., Demuth, I., Hartmann, A., Hartmann, C., Wittig, F., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk2814 · Cited by 13

The role of SET/I2PP2A in canine mammary tumors

Kake, S., Tsuji, S., Enjoji, S., Hanasaki, S., Hayase, H., Yabe, R., Tanaka, Y., Nakagawa, T., Liu, H., Chang, S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04291-7 · Cited by 13

Correction: TBC1D3, a Hominoid-Specific Gene, Delays IRS-1 Degradation and Promotes Insulin Signaling by Modulating p70 S6 Kinase Activity

Wainszelbaum, M. J., Liu, J., Chen, K., Srikanth, P., Samovski, D., Su, X., & Stahl, P. D. (2012) · PLoS ONE · doi:10.1371/annotation/6ef317b6-c9eb-44a4-8e4d-556d064ce987 · Cited by 13

Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling

Jeong, E. B., Jeong, S. S., Cho, E., & Kim, E. Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215688 · Cited by 12

Maternal starvation primes progeny response to nutritional stress

Voo, K., Hui, J. C. W., Lim, J. W. H., Chan, S. N., Ng, A. Y. E., Heng, J. Y. Y., Lim, S. S., & Pek, J. W. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009932 · Cited by 11

The B56γ3-containing protein phosphatase 2A attenuates p70S6K-mediated negative feedback loop to enhance AKT-facilitated epithelial-mesenchymal transition in colorectal cancer

Hsiao, K.-C., Ruan, S.-Y., Chen, S.-M., Lai, T.-Y., Chan, R., Zhang, Y., Chu, C., Cheng, H., Tsai, H., Tu, Y., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01182-5 · Cited by 9

Proteome analysis revealed the essential functions of protein phosphatase PP2A in the induction of Th9 cells

Roy, S., Goel, R., Aggarwal, S., Asthana, S., Yadav, A. K., & Awasthi, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-67845-2 · Cited by 9

Multiple functions of the scaffold protein Discs large 5 in the control of growth, cell polarity and cell adhesion in Drosophila melanogaster

Venugopal, P., Veyssière, H., Couderc, J., Richard, G., Vachias, C., & Mirouse, V. (2020) · BMC Developmental Biology · doi:10.1186/s12861-020-00218-0 · Cited by 9

PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma

Akaike, K., Suehara, Y., Kohsaka, S., Hayashi, T., Tanabe, Y., Kazuno, S., Mukaihara, K., Ishii, M., Kurihara, T., Kim, Y., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25392 · Cited by 8

Finding new edges: systems approaches to MTOR signaling

Heberle, A. M., Rehbein, U., Rodríguez-Peiris, M., & Thedieck, K. (2021) · Biochemical Society Transactions · doi:10.1042/bst20190730 · Cited by 8

HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity

Dobersch, S., Yamamoto, N., Schutter, A., Cavender, S. M., Robertson, T. M., Kartha, N., Samraj, A. N., Doron, B., Poole, L. A., Wladyka, C. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60129-1 · Cited by 8

Wdr59 promotes or inhibits TORC1 activity depending on cellular context

Zhang, Y.-B., Ting, C.-Y., Yang, S., Reich, J., Fru, K. N., & Lilly, M. (2022) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2212330120 · Cited by 9

Calcium-Dependent Regulation of Neuronal Excitability Is Rescued in Fragile X Syndrome by a Tat-Conjugated N-Terminal Fragment of FMRP

Zhan, X., Asmara, H., Pfaffinger, P. J., & Turner, R. W. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0136-24.2024 · Cited by 6

Phenotypic characterization of SETD3 knockout Drosophila

Tiebe, M., Lutz, M., Levy, D., & Teleman, A. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0201609 · Cited by 7

PP2Acα-B′/PR61 Holoenzyme of Toxoplasma gondii Is Required for the Amylopectin Metabolism and Proliferation of Tachyzoites

Zhao, M., Yang, Y., Shi, Y., Chen, X., Yang, Y., Pan, L., Du, Z., Sun, H., Yao, C., Ma, G., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00104-23 · Cited by 7

Pathogenic de novo variants in PPP2R5C cause a neurodevelopmental disorder within the Houge-Janssens syndrome spectrum

Verbinnen, I., Douzgou, S., Hsieh, T., Lesmann, H., Kirchhoff, A., Geneviève, D., Brimble, E., Lenaerts, L., Haesen, D., Levy, R. J., et al. (2025) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2025.01.021 · Cited by 6

Microcystin‐LR exposure disrupts the insulin signaling pathway in C2C12 mice muscle cell line

Ma, T., Cao, N., Chen, K., Wang, H., Xu, L., Xu, C., & Huang, P. (2019) · Environmental Toxicology · doi:10.1002/tox.22856 · Cited by 6

InAKTivation of insulin/IGF-1 signaling by dephosphorylation

Narasimhan, S. D., Mukhopadhyay, A., & Tissenbaum, H. A. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10072 · Cited by 19

Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase

Bielinski, V. A., & Mumby, M. C. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.05.008 · Cited by 38

A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation

Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S. D., Tesz, G. J., Czech, M., & Tissenbaum, H. A. (2009) · Cell · doi:10.1016/j.cell.2009.01.025 · Cited by 170

ACCELERATED PUBLICATION Insulin-induced Drosophila S6 kinase activation requires phosphoinositide

(2015)

Phosphatase PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis

Cheng, Y.-S. (2015) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00018759