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Cited by 462

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

Open access
Welsh, Gavin I., Hale, Lorna J., Eremina, Vera, Jeansson, Marie, Maezawa, Yoshiro, Lennon, Rachel, Pons, Deborah A., Owen, Rachel J., Satchell, Simon C., Miles, Mervyn J., Caunt, Christopher J., McArdle, Craig A., Pavenstädt, Hermann, Tavaré, Jeremy M., Herzenberg, Andrew M., Kahn, C. Ronald, Mathieson, Peter W., Quaggin, Susan E., Saleem, Moin A., Coward, Richard J.M.·2010·Cell Metabolism
DOI 10.1016/j.cmet.2010.08.015
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Abstract

Summary Diabetic nephropathy (DN) is the leading cause of renal failure in the world. It is characterized by albuminuria and abnormal glomerular function and is considered a hyperglycaemic “microvascular’ complication of diabetes, implying a primary defect in the endothelium. However, we have previously shown that human podocytes have robust responses to insulin. To determine whether insulin signaling in podocytes affects glomerular function in vivo we generated mice with specific deletion of the insulin receptor from their podocytes. These animals develop significant albuminuria together with histological features that recapitulate DN, but in a normoglycaemic environment. Examination of “normal” insulin responsive podocytes in vivo and in vitro demonstrates that insulin signals through the MAPK and PI3-kinase pathways via the insulin receptor and directly remodels the actin cytoskeleton of this cell. Collectively, this work reveals the critical importance of podocyte insulin sensitivity for kidney function.

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Metadata

Authors
Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., Caunt, C. J., McArdle, C. A., Pavenstädt, H., Tavaré, J. M., Herzenberg, A. M., Kahn, C. R., Mathieson, P. W., Quaggin, S. E., Saleem, M. A., & Coward, R. J. M.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2010-10
Volume
12
Issue
4
Pages
329-340
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2010.08.015
OpenAlex
W2157212924
Cited by
462
References
52
FWCI
19.42
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function. https://app.cochat.ai/papers/10.1016/j.cmet.2010.08.015
The paper
Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., Caunt, C. J., McArdle, C. A., Pavenstädt, H., Tavaré, J. M., Herzenberg, A. M., Kahn, C. R., Mathieson, P. W., Quaggin, S. E., Saleem, M. A., & Coward, R. J. M. (2010). Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function. Cell Metabolism. https://doi.org/10.1016/j.cmet.2010.08.015

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.