The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression
Abstract
Recent molecular insights have established the podocyte as a key component of the glomerular filtration barrier, and hence an important common pathway in proteinuric diseases. A conditionally immortalized human podocyte cell line has been developed by transfection with the temperature-sensitive SV40-T gene. These cells proliferate at the "permissive" temperature (33 degrees C). After transfer to the "nonpermissive" temperature (37 degrees C), they entered growth arrest and expressed markers of differentiated in vivo podocytes, including the novel podocyte proteins, nephrin, podocin, CD2AP, and synaptopodin, and known molecules of the slit diaphragm ZO-1, alpha-, beta-, and gamma-catenin and P-cadherin. The differentiation was accompanied by a growth arrest and the upregulation of cyclin-dependent kinase inhibitors, p27 and p57, as well as cyclin D(1), whereas cyclin A was downregulated. These data are consistent with cell cycle protein expression during podocyte maturation in vivo. In conclusion, the development of this cell line provides a new tool in the study of podocyte biology, which will enable accurate assessment of the behavior of these complex cells in health and disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Kestilä, M., Lenkkeri, U., Männikkö, M., Lamerdin, J., McCready, P., Putaala, H., Ruotsalainen, V., Morita, T., Nissinen, M., Herva, R., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80057-x · Cited by 1,866
Boute, N., Gribouval, O., Roselli, S., Benessy, F., Lee, H., Fuchshuber, A., Dahan, K., Gubler, M.-C., Niaudet, P., & Antignac, C. (2000) · Nature Genetics · doi:10.1038/74166 · Cited by 1,444
Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis
Kaplan, J. M., H Kim, S., North, K. N., Rennke, H., A Correia, L., Tong, H.-Q., Mathis, B. J., Rodríguez-Pérez, J.-C., Allen, P. G., Beggs, A. H., et al. (2000) · Nature Genetics · doi:10.1038/73456 · Cited by 1,235
Mundel, P., Reiser, J., Borja, A. Z. M., Pavenstädt, H., Davidson, G. R., Kriz, W., & Zeller, R. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3739 · Cited by 877
Self-citationCongenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein
Shih, N.-Y., Li, J., Karpitskii, V., Nguyen, A., Dustin, M. L., Kanagawa, O., Miner, J. H., & Shaw, A. S. (1999) · Science · doi:10.1126/science.286.5438.312 · Cited by 861
Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse.
Jat, P. S., Noble, M. D., Ataliotis, P., Tanaka, Y., Yannoutsos, N., Larsen, L., & Kioussis, D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.12.5096 · Cited by 744
Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
Kreidberg, J. A., Donovan, M. J., Goldstein, S. L., Rennke, H., Shepherd, K., Jones, R. C., & Jaenisch, R. (1996) · Development · doi:10.1242/dev.122.11.3537 · Cited by 723
Dustin, M. L., Olszowy, M. W., Holdorf, A. D., Li, J., Bromley, S., Desai, N., Widder, P., Rosenberger, F., van der Merwe, P. A., Allen, P. M., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81608-6 · Cited by 723
Synaptopodin: An Actin-associated Protein in Telencephalic Dendrites and Renal Podocytes
Mundel, P., Heid, H. W., Mundel, T. M., Krüger, M., Reiser, J., & Kriz, W. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.1.193 · Cited by 592
Self-citationBARISONI, L., KRIZ, W., MUNDEL, P., & D'AGATI, V. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v10151 · Cited by 557
Self-citation
Cited by
M-Type Phospholipase A 2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy
Beck, L. H., Bonegio, R. G. B., Lambeau, G., Beck, D. M., Powell, D. W., Cummins, T. D., Klein, J. B., & Salant, D. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810457 · Cited by 2,347
Cell biology of the glomerular podocyte
Pavenstädt, H., Kriz, W., & Kretzler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00020.2002 · Cited by 1,499
Hartleben, B., Gödel, M., Meyer-Schwesinger, C., Liu, S., Ulrich, T., Köbler, S., Wiech, T., Grahammer, F., Arnold, S. J., Lindenmeyer, M. T., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39492 · Cited by 721
Musah, S., Mammoto, A., Ferrante, T. C., Jeanty, S. S. F., Hirano-Kobayashi, M., Mammoto, T., Roberts, K., Chung, S., Novak, R., Ingram, M., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0069 · Cited by 538
Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function
Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.015 · Cited by 462
Self-citation
Metadata
- Authors
- Saleem, M. A., O’Hare, M. J., Reiser, J., Coward, R. J., Inward, C. D., Farren, T., Xing, C. Y., Ni, L., Mathieson, P. W., & Mundel, P.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2002-03
- Volume
- 13
- Issue
- 3
- Pages
- 630-638
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2168450345
- Cited by
- 1,120
- References
- 36
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression. https://app.cochat.ai/papers/10.1681/asn.v133630
- The paper
- Saleem, M. A., O’Hare, M. J., Reiser, J., Coward, R. J., Inward, C. D., Farren, T., Xing, C. Y., Ni, L., Mathieson, P. W., & Mundel, P. (2002). A Conditionally Immortalized Human Podocyte Cell Line Demonstrating Nephrin and Podocin Expression. Journal of the American Society of Nephrology. https://doi.org/10.1681/asn.v133630
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
