Cited by 1,986Dietary Effects on HealthCircadian rhythm and melatoninDiet, Metabolism, and Disease

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

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Abstract

While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.

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Crossref · 10.1016/j.cmet.2012.04.019

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Metadata

Authors
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., Ellisman, M. H., & Panda, S.
Affiliations
  • Salk Institute for Biological Studies (US)
  • University of California San Diego (US)
Corresponding author
Panda, Satchidananda
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2012-06
Volume
15
Issue
6
Pages
848-860
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2123319274
Cited by
1,986
References
53
Citations by year
2026: 131 · 2025: 159 · 2024: 158 · 2023: 179 · 2022: 202 · 2021: 203 · 2020: 226 · 2019: 139 · 2018: 123 · 2017: 116 · 2016: 101 · 2015: 89 · 2014: 83 · 2013: 55 · 2012: 18
FWCI
52.54
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences (P41GM103412)
  • National Institute of Diabetes and Digestive and Kidney Diseases (T32-DK07202, DK 091618, R01DK091618, T32DK007202)
  • National Center for Research Resources (P41RR004050)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
time-restricted feeding, high-fat diet, diet-induced obesity, metabolic disorders, circadian clock, hepatic steatosis, hyperinsulinemia, inflammation, motor coordination, CREB, mTOR, AMPK, liver metabolome, energy expenditure
MeSH terms
Adenylate Kinase, Animals, Bile Acids and Salts, Adipose Tissue, Brown, Energy Intake, Cholesterol, Circadian Rhythm, Eating, Energy Metabolism, Fatty Liver, Glucose, Homeostasis, Liver, Male, Metabolic Diseases, Mice, Inbred C57BL, Oxygen Consumption, Phosphorylation, Time Factors, Weight Gain, Gene Expression, Cytokines, Cyclic AMP Response Element-Binding Protein, Ribosomal Protein S6 Kinases, Adiposity, Lipid Metabolism, Mice, Adipose Tissue, White, TOR Serine-Threonine Kinases, Diet, High-Fat

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