The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Open accessAbstract
While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night, disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time-restricted feeding (tRF) of a HFD for 8 hr per day. Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination. The tRF regimen improved CREB, mTOR, and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome and improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a nonpharmacological strategy against obesity and associated diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Additionally, time-restricted feeding was found to compensate for the adverse effects of an unhealthy (high-fat) diet (57).”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [57]
In the citing paper
“Recent evidence from animal trials reported that eating at inappropriate circadian times may contribute to a poorer weight management and metabolic health [6,7,8].”
From Chronotype and Adherence to the Mediterranean Diet in Obesity: Results from the Opera Prevention Project (2020) · cites this paper as [7]
In the citing paper
“Studies in mice have reported beneficial effects of IF against diabetes and obesity with improvements in glucose tolerance and insulin sensitivity, maintenance of insulinemia within normal levels, and improvements in the phosphorylated cyclic AMP response element-binding protein (CREB), rapamycin complex (mTOR), and AMP-activated protein kinase (AMPK) pathways, even in mice fed high-fat diets [256”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [336]
In the citing paper
“Restriction of feeding to either the middle of the light (84) or dark (42) phase reduces body weight and improves markers of metabolic health in mice compared with ad libitum fed controls.”
From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [42]
In the citing paper
“Of significance, mice that were fed a high-fat diet in a time-restricted manner, i.e. with regular fasting breaks, had lower inflammatory markers, no fatty liver and were slim in comparison to mice with equivalent total number of calories consumed ad libitum (Hatori et al., 2012).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Hatori et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220
Preitner, N., Damiola, F., Luis-Lopez-Molina, Zakany, J., Duboule, D., Albrecht, U., & Schibler, U. (2002) · Cell · doi:10.1016/s0092-8674(02)00825-5 · Cited by 2,198
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice
Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 1,004
Circadian regulation of lipid mobilization in white adipose tissues
Shostak, A., Meyer-Kovac, J., & Oster, H. (2013) · Diabetes · doi:10.2337/db12-1449 · Cited by 243
Time-restricted feeding and risk of metabolic disease: A review of human and animal studies
Rothschild, J., Hoddy, K. K., Jambazian, P., & Varady, K. A. (2014) · Nutrition Reviews · doi:10.1111/nure.12104 · Cited by 241
Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals
Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235
Pillon, N. J., Loos, R. J. F., Marshall, S. M., & Zierath, J. R. (2021) · Cell · doi:10.1016/j.cell.2021.02.012 · Cited by 247
Lung adenocarcinoma distally rewires hepatic circadian homeostasis
Masri, S., Papagiannakopoulos, T., Kinouchi, K., Liu, Y., Cervantes, M., Baldi, P., Jacks, T., & Sassone-Corsi, P. (2016) · Cell · doi:10.1016/j.cell.2016.04.039 · Cited by 234
PPARs as Nuclear Receptors for Nutrient and Energy Metabolism
Hong, F., Pan, S., Guo, Y., Xu, P., & Zhai, Y. (2019) · Molecules · doi:10.3390/molecules24142545 · Cited by 233
Adafer, R., Messaadi, W., Meddahi, M., Patey, A., Haderbache, A., Bayen, S., & Messaadi, N. (2020) · Nutrients · doi:10.3390/nu12123770 · Cited by 243
Circadian rhythms of liver physiology and disease: experimental and clinical evidence
Tahara, Y., & Shibata, S. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.8 · Cited by 238
Flanagan, A., Bechtold, D. A., Pot, G. K., & Johnston, J. D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15246 · Cited by 258
Kahleova, H., Belinova, L., Malinska, H., Oliyarnyk, O., Trnovska, J., Skop, V., Kazdova, L., Dezortova, M., Hajek, M., Tura, A., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3253-5 · Cited by 229
PPARs Integrate the Mammalian Clock and Energy Metabolism
Chen, L., & Yang, G. (2014) · PPAR Research · doi:10.1155/2014/653017 · Cited by 229
Impact of nutrients on circadian rhythmicity
Oosterman, J. E., Kalsbeek, A., la Fleur, S. E., & Belsham, D. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2014 · Cited by 221
Obesity and insulin resistance: Pathophysiology and treatment
Tong, Y. A., Xu, S., Huang, L., & Chen, C. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.11.001 · Cited by 232
Hatori, M., Gronfier, C., Van Gelder, R. N., Bernstein, P. S., Carreras, J., Panda, S., Marks, F., Sliney, D., Hunt, C. E., Hirota, T., et al. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0010-2 · Cited by 212
Self-citationNutrition and the circadian system
Potter, G. D. M., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · British Journal of Nutrition · doi:10.1017/s0007114516002117 · Cited by 220
Kim, K.-H., Kim, Y. H., Son, J. E., Lee, J. H., Kim, S., Choe, M. S., Moon, J. H., Zhong, J., Fu, K., Lenglin, F., et al. (2017) · Cell Research · doi:10.1038/cr.2017.126 · Cited by 224
Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
Krishnaiah, S., Wu, G., Altman, B. J., Growe, J., Rhoades, S. D., Coldren, F., Venkataraman, A., Olarerin-George, A. O., Francey, L. J., Mukherjee, S., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.019 · Cited by 211
Time-Restricted Eating: Benefits, Mechanisms, and Challenges in Translation
Regmi, P., & Heilbronn, L. K. (2020) · iScience · doi:10.1016/j.isci.2020.101161 · Cited by 232
Moreno, C. R. D. C., Marqueze, E. C., Sargent, C., Wright, K. P., Ferguson, S. A., & Tucker, P. (2019) · Industrial Health · doi:10.2486/indhealth.sw-1 · Cited by 246
McCommis, K. S., Chen, Z., Fu, X., McDonald, W. G., Colca, J. R., Kletzien, R. F., Burgess, S. C., & Finck, B. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.028 · Cited by 211
Human blood metabolite timetable indicates internal body time
Kasukawa, T., Sugimoto, M., Hida, A., Minami, Y., Mori, M., Honma, S., Honma, K.-I., Mishima, K., Soga, T., & Ueda, H. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207768109 · Cited by 211
Circadian regulation of metabolism
Bailey, S. M., Udoh, U. S., & Young, M. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0200 · Cited by 219
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application
Hofer, S. J., Carmona‐Gutiérrez, D., Mueller, M. I., & Madeo, F. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202114418 · Cited by 213
Che, T., Cheng, Y. Z., Tian, D., Zhang, X., Liu, X., & Wu, Z. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00613-9 · Cited by 221
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Xiao, Y.-L., Gong, Y., Qi, Y.-J., Shao, Z., & Jiang, Y.-Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01771-x · Cited by 218
Cai, H., Qin, Y.-L., Shi, Z.-Y., Chen, J.-H., Zeng, M.-J., Zhou, W., Chen, R.-Q., & Chen, Z.-Y. (2019) · BMC Gastroenterology · doi:10.1186/s12876-019-1132-8 · Cited by 205
Depner, C. M., Melanson, E. L., Eckel, R. H., Snell-Bergeon, J. K., Perreault, L., Bergman, B. C., Higgins, J. A., Guerin, M. K., Stothard, E. R., Morton, S. J., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.01.069 · Cited by 203
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis
Sato, S., Dyar, K. A., Treebak, J. T., Jepsen, S. L., Ehrlich, A. M., Ashcroft, S. P., Trost, K., Kunzke, T., Prade, V. M., Small, L., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2021.12.016 · Cited by 203
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet
Tognini, P., Murakami, M., Liu, Y., Eckel‐Mahan, K. L., Newman, J. C., Verdin, E. M., Baldi, P., & Sassone‐Corsi, P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.015 · Cited by 207
Circadian disruption, clock genes, and metabolic health
Schrader, L. A., Ronnekleiv‐Kelly, S. M., Hogenesch, J. B., Bradfield, C. A., & Malecki, K. M. C. (2024) · Journal of Clinical Investigation · doi:10.1172/jci170998 · Cited by 229
Zeb, F., Wu, X., Chen, L., Fatima, S., Haq, I.-U., Chen, A., Majeed, F., Feng, Q., & Li, M. (2020) · British Journal of Nutrition · doi:10.1017/s0007114519003428 · Cited by 202
The effect of shift work on eating habits: a systematic review
Souza, R. V., Sarmento, R. A., de Almeida, J. C., & Canuto, R. (2018) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3759 · Cited by 218
Iwasaki, Y., Sendo, M., Dezaki, K., Hira, T., Sato, T., Nakata, M., Goswami, C., Aoki, R., Arai, T., Kumari, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02488-y · Cited by 200
High-fat diet acutely affects circadian organisation and eating behavior
Pendergast, J. S., Branecky, K. L., Yang, W., Ellacott, K. L. J., Niswender, K. D., & Yamazaki, S. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12133 · Cited by 198
Tahara, Y., & Shibata, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.049 · Cited by 198
Nutrients, Clock Genes, and Chrononutrition
Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198
The mammalian circadian clock and its entrainment by stress and exercise
Tahara, Y., Aoyama, S., & Shibata, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-016-0450-7 · Cited by 198
Effects of intermittent fasting on glucose and lipid metabolism
Antoni, R., Johnston, K. L., Collins, A. L., & Robertson, M. D. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116002986 · Cited by 199
Papakonstantinou, E., Oikonomou, C., Nychas, G., & Dimitriadis, G. D. (2022) · Nutrients · doi:10.3390/nu14040823 · Cited by 199
Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses
Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Hattori-Muroi, K., et al. (2019) · Cell · doi:10.1016/j.cell.2019.07.047 · Cited by 201
Sharpton, S. R., Schnabl, B., Knight, R., & Loomba, R. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.010 · Cited by 194
Mitochondrial Hormesis and Diabetic Complications
Sharma, K. (2015) · Diabetes · doi:10.2337/db14-0874 · Cited by 194
Regulation of metabolism by long, non-coding RNAs
Kornfeld, J., & Brüning, J. C. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00057 · Cited by 197
Nohara, K., Mallampalli, V. K. P. S., Nemkov, T. G., Wirianto, M., Yang, J., Ye, Y., Sun, Y., Han, L., Esser, K. A., Mileykovskaya, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11926-y · Cited by 185
Hepatic lipid droplet homeostasis and fatty liver disease
Seebacher, F., Zeigerer, A., Kory, N., & Krahmer, N. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.04.011 · Cited by 197
Schroeder, A., & Colwell, C. S. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.09.002 · Cited by 201
Weger, B. D., Gobet, C., David, F. P. A., Atger, F., Martín, E., Phillips, N. E., Charpagne, A., Weger, M., Naef, F., & Gachon, F. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015803118 · Cited by 195
TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator
Tsai, V. W.-W., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jørgensen, S. B., Lee-Ng, K. K. M., Zhang, H. P., Wu, L., Marquis, C. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055174 · Cited by 188
The Limits of Exercise Physiology: From Performance to Health
Gabriel, B. M., & Zierath, J. R. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.018 · Cited by 193
PARPs in lipid metabolism and related diseases
Szántó, M., Gupte, R., Kraus, W. L., Pacher, P., & Bai, P. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101117 · Cited by 181
Martens, C. R., Rossman, M. J., Mazzo, M. R., Jankowski, L. R., Nagy, E. E., Denman, B. A., Richey, J. J., Johnson, S. A., Ziemba, B. P., Wang, Y., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00156-6 · Cited by 182
Circadian regulation of lipid metabolism
Gooley, J. J. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 194
Manoogian, E. N. C., Zadourian, A., Lo, H. C., Gutierrez, N. R., Shoghi, A., Rosander, A. M., Pazargadi, A., Ormiston, C. K., Wang, X., Sui, J., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.08.018 · Cited by 191
Self-citationMetabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
Xie, S., Xu, S., Deng, W., & Tang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01378-8 · Cited by 197
Prolonged Nightly Fasting and Breast Cancer Prognosis
Marinac, C. R., Nelson, S. H., Breen, C. I., Hartman, S. J., Natarajan, L., Pierce, J. P., Flatt, S. W., Sears, D. D., & Patterson, R. E. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.0164 · Cited by 187
Huang, S., Chen, J., Cui, Z., Ma, K., Wu, D., Luo, J., Li, F., Xiong, W., Rao, S., Xiang, Q., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi7337 · Cited by 186
Jakubowicz, D., Wainstein, J., Landau, Z., Raz, I., Ahren, B., Chapnik, N., Ganz, T., Menaged, M., Barnea, M., Bar-Dayan, Y., et al. (2017) · Diabetes Care · doi:10.2337/dc16-2753 · Cited by 178
Circadian metabolism in the light of evolution
Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178
Postindustrial Metabolism: Fat Knowledge
Landecker, H. L. (2013) · Public Culture · doi:10.1215/08992363-2144625 · Cited by 177
High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry -deficient mice
Barclay, J. L., Shostak, A., Leliavski, A., Tsang, A. H., Jöhren, O., Müller-Fielitz, H., Landgraf, D., Naujokat, N., van der Horst, G. T. J., & Oster, H. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2012 · Cited by 173
Arble, D. M., Bass, J., Behn, C. D., Butler, M. P., Challet, E., Czeisler, C., Depner, C. M., Elmquist, J., Franken, P., Grandner, M. A., et al. (2015) · Sleep · doi:10.5665/sleep.5226 · Cited by 173
Self-citationA Prader–Willi locus lncRNA cloud modulates diurnal genes and energy expenditure
Powell, W. T., Coulson, R. L., Crary, F. K., Wong, S. S., Ach, R. A., Tsang, P., Alice Yamada, N., Yasui, D. H., & LaSalle, J. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt281 · Cited by 173
Cook, D. N., Kang, H. S., & Jetten, A. M. (2015) · Nuclear Receptor Research · doi:10.11131/2015/101185 · Cited by 181
Dietary restriction with and without caloric restriction for healthy aging
Lee, C. D., & Longo, V. D. (2016) · F1000Research · doi:10.12688/f1000research.7136.1 · Cited by 178
Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171
Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease
Saran, A., Dave, S., & Zarrinpar, A. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.050 · Cited by 179
Self-citationA causal role for hyperinsulinemia in obesity
Templeman, N. M., Skovsø, S., Page, M. M., Lim, G. E., & Johnson, J. D. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0449 · Cited by 168
Pellegrini, M., Cioffi, I., Evangelista, A., Ponzo, V., Goitre, I., Ciccone, G., Ghigo, E., & Bo, S. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09524-w · Cited by 168
Yasumoto, Y., Hashimoto, C., Nakao, R., Yamazaki, H., Hiroyama, H., Nemoto, T., Yamamoto, S., Sakurai, M., Oike, H., Wada, N., et al. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.003 · Cited by 168
Greenwell, B. J., Trott, A. J., Beytebiere, J. R., Pao, S., Bosley, A. M., Beach, E., Finegan, P., Hernandez, C., & Menet, J. S. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.064 · Cited by 168
Time-restricted feeding mitigates obesity through adipocyte thermogenesis
Hepler, C., Weidemann, B. J., Waldeck, N. J., Marcheva, B., Cedernaes, J., Thorne, A. K., Kobayashi, Y., Nozawa, R., Newman, M. V., Gao, P., et al. (2022) · Science · doi:10.1126/science.abl8007 · Cited by 167
Circadian Rhythms, Disease and Chronotherapy
Lee, Y., Field, J. M., & Sehgal, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211044301 · Cited by 185
Interconnections between circadian clocks and metabolism
Guan, D., & Lazar, M. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148278 · Cited by 173
Parr, E. B., Devlin, B. L., Radford, B. E., & Hawley, J. A. (2020) · Nutrients · doi:10.3390/nu12020505 · Cited by 169
Lipid metabolism around the body clocks
Petrenko, V., Sinturel, F., Riezman, H., & Dibner, C. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101235 · Cited by 171
Circadian disruption and human health: A bidirectional relationship
Abbott, S. M., Malkani, R. G., & Zee, P. C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14298 · Cited by 161
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
Hwangbo, D., Lee, H., Abozaid, L. S., & Min, K. (2020) · Nutrients · doi:10.3390/nu12041194 · Cited by 173
Circadian clocks in the digestive system
Segers, A., & Depoortere, I. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00401-5 · Cited by 165
The circadian coordination of cell biology
Chaix, A., Zarrinpar, A., & Panda, S. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201603076 · Cited by 159
Self-citationMurakami, M., Tognini, P., Liu, Y., Eckel‐Mahan, K. L., Baldi, P., & Sassone‐Corsi, P. (2016) · EMBO Reports · doi:10.15252/embr.201642463 · Cited by 161
Time‐restricted feeding for prevention and treatment of cardiometabolic disorders
Melkani, G. C., & Panda, S. (2017) · The Journal of Physiology · doi:10.1113/jp273094 · Cited by 155
Self-citationMcAllister, M. J., Pigg, B., Rentería, L. I., & Waldman, H. S. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.12.001 · Cited by 152
The circadian clock: a framework linking metabolism, epigenetics and neuronal function
Masri, S., & Sassone‐Corsi, P. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3393 · Cited by 161
Antoni, R., Robertson, T. M., Robertson, M. D., & Johnston, J. D. (2018) · Journal of Nutritional Science · doi:10.1017/jns.2018.13 · Cited by 154
Chrono-nutrition for the prevention and treatment of obesity and type 2 diabetes: from mice to men
Hawley, J. A., Sassone‐Corsi, P., & Zierath, J. R. (2020) · Diabetologia · doi:10.1007/s00125-020-05238-w · Cited by 159
Chrono-Nutrition: Circadian Rhythm and Personalized Nutrition
Franzago, M., Alessandrelli, E., Notarangelo, S., Stuppia, L., & Vitacolonna, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032571 · Cited by 183
Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21
Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L., & Hall, M. N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412047111 · Cited by 152
Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems
Chen, Z., Yoo, S. H., & Takahashi, J. S. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052645 · Cited by 154
Mechanism of the circadian clock in physiology
Richards, J., & Gumz, M. L. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00066.2013 · Cited by 160
Villanueva, J. E., Livelo, C., Trujillo, A. S., Chandran, S., Woodworth, B., Andrade, L., Le, H. D., Manor, U., Panda, S., & Melkani, G. C. (2019) · Nature Communications · doi:10.1038/s41467-019-10563-9 · Cited by 160
Self-citationWei, X., Lin, B., Huang, Y., Yang, S., Huang, C., Shi, L., Liu, D., Zhang, P., Lin, J., Xu, B., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.3513 · Cited by 149
Chung, H., Chou, W., Sears, D. D., Patterson, R. E., Webster, N. J. G., & Ellies, L. G. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.006 · Cited by 149
Persistent organic pollutants in adipose tissue should be considered in obesity research
Lee, Y., Kim, K. S., Jacobs, D. R., & Lee, D. ‐. (2016) · Obesity Reviews · doi:10.1111/obr.12481 · Cited by 156
Whittaker, D. S., Akhmetova, L., Carlin, D., Romero, H., Welsh, D. K., Colwell, C. S., & Desplats, P. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.014 · Cited by 147
Maukonen, M., Kanerva, N., Partonen, T., Kronholm, E., Tapanainen, H., Kontto, J., & Männistö, S. (2017) · Obesity · doi:10.1002/oby.21747 · Cited by 145
Aviram, R., Manella, G., Kopelman, N. M., Neufeld-Cohen, A., Zwighaft, Z., Elimelech, M., Adamovich, Y., Golik, M., Wang, C., Han, X., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.002 · Cited by 143
Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space
Kim, Y. H., & Lazar, M. A. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa014 · Cited by 154
Marinac, C. R., Sears, D. D., Natarajan, L., Gallo, L. C., Breen, C. I., & Patterson, R. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136240 · Cited by 144
Circadian Rhythms in Diet-Induced Obesity
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_2 · Cited by 149
Circadian rhythms in liver metabolism and disease
Ferrell, J. M., & Chiang, J. Y. L. (2015) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2015.01.003 · Cited by 151
Metadata
- Authors
- Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., Ellisman, M. H., & Panda, S.
- Affiliations
- Salk Institute for Biological Studies (US)
- University of California San Diego (US)
- Corresponding author
- Panda, Satchidananda
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 15
- Issue
- 6
- Pages
- 848-860
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3491655
- OpenAlex
- W2123319274
- Cited by
- 1,986
- References
- 53
- Citations by year
- 2026: 131 · 2025: 159 · 2024: 158 · 2023: 179 · 2022: 202 · 2021: 203 · 2020: 226 · 2019: 139 · 2018: 123 · 2017: 116 · 2016: 101 · 2015: 89 · 2014: 83 · 2013: 55 · 2012: 18
- FWCI
- 52.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (P41GM103412)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32-DK07202, DK 091618, R01DK091618, T32DK007202)
- National Center for Research Resources (P41RR004050)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- time-restricted feeding, high-fat diet, diet-induced obesity, metabolic disorders, circadian clock, hepatic steatosis, hyperinsulinemia, inflammation, motor coordination, CREB, mTOR, AMPK, liver metabolome, energy expenditure
- MeSH terms
- Adenylate Kinase, Animals, Bile Acids and Salts, Adipose Tissue, Brown, Energy Intake, Cholesterol, Circadian Rhythm, Eating, Energy Metabolism, Fatty Liver, Glucose, Homeostasis, Liver, Male, Metabolic Diseases, Mice, Inbred C57BL, Oxygen Consumption, Phosphorylation, Time Factors, Weight Gain, Gene Expression, Cytokines, Cyclic AMP Response Element-Binding Protein, Ribosomal Protein S6 Kinases, Adiposity, Lipid Metabolism, Mice, Adipose Tissue, White, TOR Serine-Threonine Kinases, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
