The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Open accessAbstract
Summary AMPK is a metabolic sensor that helps maintain cellular energy homeostasis. Despite evidence linking AMPK with tumor suppressor functions, the role of AMPK in tumorigenesis and tumor metabolism is unknown. Here we show that AMPK negatively regulates aerobic glycolysis (the Warburg effect) in cancer cells, and suppresses tumor growth in vivo. Genetic ablation of the α1 catalytic subunit of AMPK accelerates Myc-induced lymphomagenesis. Inactivation of AMPKα in both transformed and non-transformed cells promotes a metabolic shift to aerobic glycolysis, increased allocation of glucose carbon into lipids, and biomass accumulation. These metabolic effects require normoxic stabilization of the hypoxia-inducible factor-1α (HIF-1α), as silencing HIF-1α reverses the shift to aerobic glycolysis and the biosynthetic and proliferative advantages conferred by reduced AMPKα signaling. Together our findings suggest that AMPK activity opposes tumor development, and its loss fosters tumor progression in part by regulating cellular metabolic pathways that support cell growth and proliferation.
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Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Self-citationRole of AMP-Activated Protein Kinase in Mechanism of Metformin Action
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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Self-citationTSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
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Cited by
Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716
Metformin: from mechanisms of action to therapies
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Self-citationFueling Immunity: Insights into Metabolism and Lymphocyte Function
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Self-citationGlutamine blockade induces divergent metabolic programs to overcome tumor immune evasion
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Everts, B., Amiel, E., Huang, S. C.-C., Smith, A. M., Chang, C.-H., Lam, W. Y., Redmann, V., Freitas, T. C., Blagih, J., van der Windt, G. J. W., et al. (2014) · Nature Immunology · doi:10.1038/ni.2833 · Cited by 1,064
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Metadata
- Authors
- Faubert, B., Boily, G., Izreig, S., Griss, T., Samborska, B., Dong, Z., Dupuy, F., Chambers, C., Fuerth, B. J., Viollet, B., Mamer, O. A., Avizonis, D., DeBerardinis, R. J., Siegel, P. M., & Jones, R. G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 17
- Issue
- 1
- Pages
- 113-124
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2019683289
- Cited by
- 911
- References
- 53
- FWCI
- 18.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Faubert, B., Boily, G., Izreig, S., Griss, T., Samborska, B., Dong, Z., Dupuy, F., Chambers, C., Fuerth, B. J., Viollet, B., Mamer, O. A., Avizonis, D., DeBerardinis, R. J., Siegel, P. M., & Jones, R. G. (2013). AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo. Cell Metabolism. https://doi.org/10.1016/j.cmet.2012.12.001
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