The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN
Open accessAbstract
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved and the regulatory mechanisms behind this are not well understood. Here we demonstrate that NPY derived from the arcuate nucleus (Arc) is critical for the control of sympathetic outflow and brown adipose tissue (BAT) function. Mechanistically, a key change induced by Arc NPY signaling is a marked Y1 receptor-mediated reduction in tyrosine hydroxylase (TH) expression in the hypothalamic paraventricular nucleus (PVN), which is also associated with a reduction in TH expression in the locus coeruleus (LC) and other regions in the brainstem. Consistent with this, Arc NPY signaling decreased sympathetically innervated BAT thermogenesis, involving the downregulation of uncoupling protein 1 (UCP1) expression in BAT. Taken together, these data reveal a powerful Arc-NPY-regulated neuronal circuit that controls BAT thermogenesis and sympathetic output via TH neurons.
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In the citing paper
“Obesity is also accompanied by an increased NPY expression in the ARC.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [129]
In the citing paper
“This increase triggers a reduction in the expression of tyrosine hydroxylase neurons in the paraventricular nucleus (PVN) of the hypothalamus and consequently, diminishes the thermogenic activation of BAT and overall energy expenditure 129.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [129]
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Metadata
- Authors
- Shi, Y.-C., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X.-F., Enriquez, R. F., Castillo, L., Baldock, P. A., Zhang, L., Sainsbury, A., Herzog, H., & Lin, S.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Charité – Universitätsmedizin Berlin (DE)
- University of Wollongong (AU)
- The University of Sydney (AU)
- Corresponding author
- Herzog, Herbert
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 17
- Issue
- 2
- Pages
- 236-248
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2002941555
- Cited by
- 266
- References
- 49
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 19 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 20 · 2019: 16 · 2018: 23 · 2017: 25 · 2016: 21 · 2015: 28 · 2014: 27 · 2013: 8
- FWCI
- 19.45
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-07-02)
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 369 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research Online (University of Wollongong) (submittedVersion)
- The Sydney eScholarship Repository (The University of Sydney) (submittedVersion)
- Funders
- National Health and Medical Research Council (427661)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- neuropeptide Y, arcuate nucleus, paraventricular nucleus, tyrosine hydroxylase, sympathetic nervous system, brown adipose tissue, thermogenesis, UCP1, Y1 receptor, hypothalamus, locus coeruleus, energy expenditure
- MeSH terms
- Uncoupling Protein 1, Animals, Arcuate Nucleus of Hypothalamus, Adipose Tissue, Brown, Energy Metabolism, Feeding Behavior, Gene Expression Regulation, Glutamate Decarboxylase, Ion Channels, Male, Mice, Inbred C57BL, Neurons, Neuropeptide Y, Oxygen Consumption, Paraventricular Hypothalamic Nucleus, Pro-Opiomelanocortin, RNA, Messenger, Sympathetic Nervous System, Temperature, Tyrosine 3-Monooxygenase, Signal Transduction, Receptors, Neuropeptide Y, Thermogenesis, Models, Animal, Mitochondrial Proteins, Mice, Agouti-Related Protein, Diet, High-Fat
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