The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets
Open accessAbstract
SUMMARY Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing β-cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and non-diabetic organ donors. We identified a cluster of miRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human β-cells and dramatically down-regulated in islets from T2DM organ donors. The down-regulation of this locus strongly correlates with hyper-methylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1 that cause increased β-cell apoptosis upon over-expression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
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Cites
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Cited by
β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment
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“study has revealed an epigenetic mechanism in islets from patients with T2D (33).”
BackgroundMicroRNA-mediated regulation of glucose and lipid metabolism
Agbu, P., & Carthew, R. W. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00354-w · Cited by 363
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Pancreatic β-cell identity, glucose sensing and the control of insulin secretion
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The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes
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Metadata
- Authors
- Kameswaran, V., Bramswig, N. C., McKenna, L. B., Penn, M., Schug, J., Hand, N. J., Chen, Y., Choi, I., Vourekas, A., Won, K.-J., Liu, C., Vivek, K., Naji, A., Friedman, J. R., & Kaestner, K. H.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 19
- Issue
- 1
- Pages
- 135-145
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2025891649
- Cited by
- 318
- References
- 50
- FWCI
- 31.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Kameswaran, V., Bramswig, N. C., McKenna, L. B., Penn, M., Schug, J., Hand, N. J., Chen, Y., Choi, I., Vourekas, A., Won, K.-J., Liu, C., Vivek, K., Naji, A., Friedman, J. R., & Kaestner, K. H. (2014). Epigenetic Regulation of the DLK1-MEG3 MicroRNA Cluster in Human Type 2 Diabetic Islets. Cell Metabolism. https://doi.org/10.1016/j.cmet.2013.11.016
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