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Cited by 1,673MicroRNA in disease regulationPlant Molecular Biology ResearchRNA Research and Splicing

MicroRNAs in Stress Signaling and Human Disease

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Mendell, Joshua T., Olson, Eric N.·2012·Cell
DOI 10.1016/j.cell.2012.02.005PMC PMC3308137
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Abstract

Disease is often the result of an aberrant or inadequate response to physiologic and pathophysiologic stress. Studies over the last 10 years have uncovered a recurring paradigm in which microRNAs (miRNAs) regulate cellular behavior under these conditions, suggesting an especially significant role for these small RNAs in pathologic settings. Here, we review emerging principles of miRNA regulation of stress signaling pathways and apply these concepts to our understanding of the roles of miRNAs in disease. These discussions further highlight the unique challenges and opportunities associated with the mechanistic dissection of miRNA functions and the development of miRNA-based therapeutics.

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  • The vast majority of miRNA knock-out mice examined thus far lack any strong phenotypes under normal physiological conditions.

    “Somewhat unexpectedly, the vast majority of miRNA knock-out mice examined thus far lack any strong phenotypes under normal physiological conditions (Ebert and Sharp, 2012;Mendell and Olson, 2012).”

    From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Mendell and Olson, 2012

    In “Lessons from miRNA loss-of-function studies in model organisms” (page unavailable), the review says the majority of approximately 25 mouse miRNA knockouts examined lacked embryonic developmental defects, and many showed abnormalities only under stress. This supports the general point, but it does not establish that the vast majority lacked any strong phenotype under normal physiological conditions; its explicit mouse finding is narrower and says “majority.” (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • miR-21 is commonly upregulated in a stress environment.

    “It would seem to suggest that miR-21 is commonly upregulated in a stress environment [1].”

    From miR-21: a non‐specific biomarker of all maladies (2021) · cites this paper as [1]

    The ‘MicroRNAs in Cardiovascular Disease’ section states that miR-21 is upregulated in response to cardiac stress. It does not establish that miR-21 is commonly upregulated across stress environments generally; the cited evidence is specific to cardiac stress. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • MicroRNAs control essential cell processes in health and disease.

    “In this role, they control essential cell processes in health and disease (Ambros 2004; Mendell and Olson 2012).”

    From Toward the human cellular microRNAome (2017) · cites this paper as Mendell and Olson 2012

  • miRNAs play a critical role especially under pathologic conditions such as injury and stress.

    “miRNAs play a critical role especially under pathologic conditions such as injury and stress (Leung and Sharp, 2010; Mendell and Olson, 2012)”

    From miR-219 Cooperates with miR-338 in Myelination and Promotes Myelin Repair in the CNS (2017) · cites this paper as Mendell and Olson, 2012

  • miRNAs are short, ∼22-nt, critical regulatory elements that repress protein translation and promote degradation of messenger RNA.

    “MicroRNAs (miRNAs) are short, ∼22-nt, critical regulatory elements that repress protein translation and promote degradation of messenger RNA (mRNA) [1, 2].”

    From A curated human cellular microRNAome based on 196 primary cell types (2022) · cites this paper as [2]

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Authors
Mendell, J. T., & Olson, E. N.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Mendell, Joshua T.
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2012-03
Volume
148
Issue
6
Pages
1172-1187
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2012.02.005
PMC
PMC3308137
OpenAlex
W2015284016
Cited by
1,673
References
13
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FWCI
12.69
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5u01hl100401-07)
  • National Heart, Lung, and Blood Institute (R01HL111665, R01HL77439, R01HL077439, U01-HL-100401, R01HL093039)
  • National Cancer Institute (R01CA120185, P01CA134292)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
microRNA, stress signaling, stress response, miRNA-based therapy, pathogenesis
MeSH terms
Animals, Disease, Humans, Signal Transduction, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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