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Cited by 130Pancreatic function and diabetesNeuroscience of respiration and sleepDiabetes Management and Research

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Hypoglycemia-Activated GLUT2 Neurons of the Nucleus Tractus Solitarius Stimulate Vagal Activity and Glucagon Secretion

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Lamy, Christophe M., Sanno, Hitomi, Labouèbe, Gwenaël, Picard, Alexandre, Magnan, Christophe, Chatton, Jean-Yves, Thorens, Bernard·2014·Cell Metabolism
DOI 10.1016/j.cmet.2014.02.003
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Abstract

Glucose-sensing neurons in the brainstem participate in the regulation of energy homeostasis but have been poorly characterized because of the lack of specific markers to identify them. Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated neurons. Their response to low glucose is mediated by reduced intracellular glucose metabolism, increased AMP-activated protein kinase activity, and closure of leak K(+) channels. These are GABAergic neurons that send projections to the vagal motor nucleus. Light-induced stimulation of channelrhodospin-expressing GLUT2 neurons in vivo led to increased parasympathetic nerve firing and glucagon secretion. Thus GLUT2 neurons of the nucleus tractus solitarius link hypoglycemia detection to counterregulatory response. These results may help identify the cause of hypoglycemia-associated autonomic failure, a major threat in the insulin treatment of diabetes.

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Metadata

Authors
Lamy, C. M., Sanno, H., Labouèbe, G., Picard, A., Magnan, C., Chatton, J.-Y., & Thorens, B.
Affiliations
  • University of Fribourg (CH)
  • University of Lausanne (CH)
Corresponding author
  • Chatton, Jean-Yves
  • Thorens, Bernard
ORCID
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2014-03
Volume
19
Issue
3
Pages
527-538
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2014.02.003
OpenAlex
W2026372454
Cited by
130
References
35
Citations by year
2026: 3 · 2025: 5 · 2024: 8 · 2023: 14 · 2022: 15 · 2021: 19 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 5 · 2016: 13 · 2015: 10 · 2014: 8
FWCI
11.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
  • reroDoc Digital Library (submittedVersion)
  • IRIS (submittedVersion)
Funders
  • National Science Foundation
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (135720, 113525, 31003A, 3100A0)
  • Université de Lausanne
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
nucleus tractus solitarius, hypoglycemia, glucose detection, AMPK, GABAergic neurons, parasympathetic nerve activity, glucagon secretion, counterregulatory response, hypoglycemia-associated autonomic failure, diabetes mellitus, energy homeostasis
MeSH terms
Channelrhodopsins, Animals, Deoxyglucose, Glucagon, Glucosamine, Glucose, Hypoglycemia, Membrane Potentials, Mice, Transgenic, Potassium Channels, Solitary Nucleus, Patch-Clamp Techniques, Glucose Transporter Type 2, Mice, AMP-Activated Protein Kinases, GABAergic Neurons, In Vitro Techniques

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