The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication
Open accessAbstract
SUMMARY Virus infections trigger metabolic changes in host cells that support the bioenergetic and biosynthetic demands of viral replication. While recent studies have characterized virus-induced changes in host cell metabolism (Munger et al., 2008; Terry et al., 2012), the molecular mechanisms by which viruses reprogram cellular metabolism have remained elusive. Here we show that the gene product of adenovirus E4ORF1 is necessary for adenovirus-induced upregulation of host cell glucose metabolism and sufficient to promote enhanced glycolysis in cultured epithelial cells by activation of MYC. E4ORF1 localizes to the nucleus, binds to MYC, and enhances MYC binding to glycolytic target genes, resulting in elevated expression of specific glycolytic enzymes. E4ORF1 activation of MYC promotes increased nucleotide biosynthesis from glucose intermediates and enables optimal adenovirus replication in primary lung epithelial cells. Our findings show how a viral protein exploits host cell machinery to reprogram cellular metabolism and promote optimal progeny virion generation.
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 1×
“MYC-dependent transcription has also been implicated in metabolic reprogramming toward increased glycolysis and glutaminolysis to support biosynthesis during activation of primary T lymphocytes (Wang et al., 2011).”
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043
c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth
Shim, H., Dolde, C., Lewis, B. C., Wu, C.-S., Dang, G., Jungmann, R. A., Dalla-Favera, R., & Dang, C. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.13.6658 · Cited by 1,092
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Rozenblatt-Rosen, O., Deo, R. C., Padi, M., Adelmant, G., Calderwood, M. A., Rolland, T., Grace, M., Dricot, A., Askenazi, M., Tavares, M., et al. (2012) · Nature · doi:10.1038/nature11288 · Cited by 378
Cited by
Viral activation of cellular metabolism
Sanchez, E. L., & Lagunoff, M. (2015) · Virology · doi:10.1016/j.virol.2015.02.038 · Cited by 560
Competition for nutrients and its role in controlling immune responses
Kedia-Mehta, N., & Finlay, D. K. (2019) · Nature Communications · doi:10.1038/s41467-019-10015-4 · Cited by 287
α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells
TeSlaa, T., Chaikovsky, A. C., Lipchina, I., Escobar, S. L., Hochedlinger, K., Huang, J., Graeber, T. G., Braas, D., & Teitell, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.002 · Cited by 287
Self-citationGlycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State
Gu, W., Gaeta, X., Sahakyan, A., Chan, A. B., Hong, C. S., Kim, R., Braas, D., Plath, K., Lowry, W. E., & Christofk, H. R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.08.008 · Cited by 283
Self-citationVirus Infections and Host Metabolism—Can We Manage the Interactions?
Sumbria, D., Berber, E., Mathayan, M., & Rouse, B. T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594963 · Cited by 147
Metadata
- Authors
- Thai, M., Graham, N. A., Braas, D., Nehil, M., Komisopoulou, E., Kurdistani, S. K., McCormick, F., Graeber, T. G., & Christofk, H. R.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 19
- Issue
- 4
- Pages
- 694-701
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2003852683
- Cited by
- 286
- References
- 5
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thai, M., Graham, N. A., Braas, D., Nehil, M., Komisopoulou, E., Kurdistani, S. K., McCormick, F., Graeber, T. G., & Christofk, H. R. (2014). Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication. Cell Metabolism. https://doi.org/10.1016/j.cmet.2014.03.009
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