Lipotoxicity, β Cell Dysfunction, and Gestational Diabetes
Open accessAbstract
Gestational diabetes (GDM) is caused by failure of islet β cells to meet the increased insulin requirements of pregnancy. Recently, Prentice et al. (2014) discovered a 7-fold elevation of the furan fatty acid metabolite 3-carboxy-4-methyl-5-propyl-2-furanopropanoic acid (CMPF) in plasma of women with GDM and showed that CMPF directly induces β cell dysfunction.
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The inner mitochondrial membrane of islet β cells fails to protect, which increases the permeability of mitochondrial membrane, leading to β cells apoptosis.
“Thus, the inner mitochondrial membrane of islet β cells fails to protect, which increases the permeability of mitochondrial membrane, leading to β cells apoptosis (75, 76).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [75]
Cites
Islet cell failure in type 2 diabetes
Prentki, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29103 · Cited by 1,690 · see citing works
Fatty Acid Signaling in the β-Cell and Insulin Secretion
Nolan, C. J., Murthy, M. S., Delghingaro‐Augusto, V., Peyot, M., & Prentki, M. (2006) · Diabetes · doi:10.2337/db06-s003 · Cited by 405 · see citing works
Self-citationBuchanan, T. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7339 · Cited by 336 · see citing works
Spiteller, G. (2005) · Lipids · doi:10.1007/s11745-005-1438-5 · Cited by 178 · see citing works
The Furan Fatty Acid Metabolite CMPF Is Elevated in Diabetes and Induces β Cell Dysfunction
Prentice, K. J., Luu, L., Allister, E. M., Liu, Y., Jun, L. S., Sloop, K. W., Hardy, A. B., Wei, L., Jia, W., Fantus, I. G., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.008 · Cited by 156 · see citing works
The common occurrence of furan fatty acids in plants
Hannemann, K., Puchta, V., Simon, E., et al. (1989) · Lipids · doi:10.1007/bf02535166 · Cited by 135 · see citing works
Koukkou, E. G., Watts, G. F., & Lowy, C. (1996) · Journal of Clinical Pathology · doi:10.1136/jcp.49.8.634 · Cited by 124 · see citing works
Controversies in gestational diabetes
Nolan, C. J. (2010) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2010.10.004 · Cited by 76 · see citing works
Self-citationBerdeaux, O., Fontagné-Dicharry, S., Sémon, E., et al. (2012) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2012.02.004 · Cited by 71 · see citing works
Miyamoto, Y., Iwao, Y., Mera, K., et al. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.033 · Cited by 43 · see citing works
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Diabetes mellitus and Alzheimer's disease: GSK-3β as a potential link
Zhang, Y., Huang, N.-Q., Yan, F., Jin, H., Zhou, S.-Y., Shi, J.-S., & Jin, F. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.015 · Cited by 301 · see citing works
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231 · see citing works
Retnakaran, R., Ye, C., Kramer, C. K., Connelly, P. W., Hanley, A. J., Sermer, M., & Zinman, B. (2016) · Diabetes Care · doi:10.2337/dc16-0043 · Cited by 64 · see citing works
- Authors
- Nolan, C. J.
- Affiliations
- Australian National University (AU)
- Corresponding author
- Nolan, Christopher J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 19
- Issue
- 4
- Pages
- 553-554
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1993277350
- Cited by
- 23
- References
- 10
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 2
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- gestational diabetes mellitus, lipotoxicity, beta-cell dysfunction, furan fatty acids, insulin resistance in pregnancy, pancreatic beta cells
- MeSH terms
- Animals, Furans, Humans, Mitochondria, Models, Biological, Propionates, Organic Anion Transporters, Sodium-Independent, Insulin-Secreting Cells
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