The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
Open accessAbstract
Estrogens play a major role in the modulation of energy balance through central and peripheral actions. Here, we demonstrate that central action of estradiol (E2) inhibits AMP-activated protein kinase (AMPK) through estrogen receptor alpha (ERα) selectively in the ventromedial nucleus of the hypothalamus (VMH), leading to activation of thermogenesis in brown adipose tissue (BAT) through the sympathetic nervous system (SNS) in a feeding-independent manner. Genetic activation of AMPK in the VMH prevented E2-induced increase in BAT-mediated thermogenesis and weight loss. Notably, fluctuations in E2 levels during estrous cycle also modulate this integrated physiological network. Together, these findings demonstrate that E2 regulation of the VMH AMPK-SNS-BAT axis is an important determinant of energy balance and suggest that dysregulation in this axis may account for the common changes in energy homeostasis and obesity linked to dysfunction of the female gonadal axis.
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Cites
Brown Adipose Tissue: Function and Physiological Significance
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
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“SC administration of E2 increased the mRNA expression or protein content of thermogenic markers, such as uncoupling protein-1 (UCP1), peroxisome-proliferator-activated receptor-gamma coactivator 1 alpha (PGC1a) and beta (PGC1b) in the BAT (Figures 2C and 2D), while no changes in browning markers (Waldén et al., 2012;…”
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The role of estrogens in control of energy balance and glucose homeostasis
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Cited by
Sex differences in metabolic regulation and diabetes susceptibility
Tramunt, B., Smati, S., Grandgeorge, N., Lenfant, F., Arnal, J.-F., Montagner, A., & Gourdy, P. (2020) · Diabetologia · doi:10.1007/s00125-019-05040-3 · Cited by 923
The sexual dimorphism of obesity
Palmer, B. F., & Clegg, D. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.029 · Cited by 919
Berberine activates thermogenesis in white and brown adipose tissue
Zhang, Z., Zhang, H., Li, B., Meng, X., Wang, J., Zhang, Y., Yao, S., Ma, Q., Jin, L., Yang, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6493 · Cited by 438
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407
AMP ‐activated protein kinase: a cellular energy sensor that comes in 12 flavours
Ross, F. A., MacKintosh, C., & Hardie, D. G. (2016) · The FEBS Journal · doi:10.1111/febs.13698 · Cited by 381
Metadata
- Authors
- Martínez de Morentin, P. B., González-García, I., Martins, L., Lage, R., Fernández-Mallo, D., Martínez-Sánchez, N., Ruíz-Pino, F., Liu, J., Morgan, D. A., Pinilla, L., Gallego, R., Saha, A. K., Kalsbeek, A., Fliers, E., Bisschop, P. H., Diéguez, C., Nogueiras, R., Rahmouni, K., Tena-Sempere, M., & López, M.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 20
- Issue
- 1
- Pages
- 41-53
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2159444491
- Cited by
- 451
- References
- 56
- FWCI
- 22.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Martínez de Morentin, P. B., González-García, I., Martins, L., Lage, R., Fernández-Mallo, D., Martínez-Sánchez, N., Ruíz-Pino, F., Liu, J., Morgan, D. A., Pinilla, L., Gallego, R., Saha, A. K., Kalsbeek, A., Fliers, E., Bisschop, P. H., Diéguez, C., Nogueiras, R., Rahmouni, K., Tena-Sempere, M., & López, M. (2014). Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK. Cell Metabolism. https://doi.org/10.1016/j.cmet.2014.03.031
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
