Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

Oldham, William M., Clish, Clary B., Yang, Yi, Loscalzo, Joseph·2015·Cell Metabolism

Cited by (363)

Items 101–200 of 363

  1. Mitochondrial redox and TCA cycle metabolite signaling in the heart
    Ana Vujić, Amy Koo, Hiran A. Prag, Thomas Krieg · 2021 · Free Radical Biology and Medicine
  2. Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure
    Mònica Bulló, Christopher Papandreou, Jesús Francisco García-Gavilán, Miguel Ruiz‐Canela, Jun Li, Marta Guasch‐Ferré, Estefanía Toledo, Clary B. Clish, Dolores Corella, Ramón Estruch et al. · 2021 · Metabolism
  3. Reductive stress triggers ANAC017-mediated retrograde signaling to safeguard the endoplasmic reticulum by boosting mitochondrial respiratory capacity
    Philippe Fuchs, Finja Bohle, Sophie Lichtenauer, José Manuel Ugalde, Elias Feitosa‐Araujo, Berivan Mansuroglu, Cristina Ruberti, Stephan Wagner, Stefanie J. Müller‐Schüssele, Andreas J. Meyer et al. · 2022 · The Plant Cell
  4. The Bidirectional Relationship Between Cancer Epigenetics and Metabolism
    Luke Izzo, Hayley C. Affronti, Kathryn E. Wellen · 2020 · Annual Review of Cancer Biology
  5. In vivo Reprogramming of Cancer Metabolism by MYC
    Roman Camarda, Jeremy R. Williams, Andrei Goga · 2017 · Frontiers in Cell and Developmental Biology
  6. Cellular Metabolism and Aging
    André Catic · 2018 · Progress in molecular biology and translational science
  7. Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions
    Bargiela, David, Burr, Stephen P., Chinnery, Patrick F. · 2018 · Trends in Endocrinology & Metabolism
  8. Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
    Bo Zhang, Hui Peng, Mi Zhou, Lei Bao, Chenliang Wang, Feng Cai, Hongxia Zhang, Jennifer E. Wang, Yan-Ling Niu, Yan Chen et al. · 2022 · Cancer Research
  9. NADH reductive stress drives metabolic reprogramming
    Ronghui Yang, Zihao Guo, Binghui Li · 2025 · Trends in Cell Biology
  10. Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
    Ingvild Comfort Hvinden, Tom A.D. Cadoux-Hudson, Christopher John Schofield, James McCullagh · 2021 · Cell Reports Medicine
  11. Emerging Metabolic Therapies in Pulmonary Arterial Hypertension
    Lloyd D. Harvey, Stephen Y. Chan · 2017 · Journal of Clinical Medicine
  12. Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
    Niamh C. Williams, Dylan G. Ryan, Ana S.H. Costa, Evanna L. Mills, Mark P. Jedrychowski, Suzanne M. Cloonan, Christian Frezza, Luke A.J. O'Neill · 2021 · Journal of Biological Chemistry
  13. Oncometabolites at the crossroads of genetic, epigenetic and ecological alterations in cancer
    Letizia Lanzetti · 2024 · Cell Death and Differentiation
  14. ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex
    Peter S. J. Bailey, Brian M. Ortmann, Anthony W. Martinelli, Jack W. Houghton, Ana S.H. Costa, Stephen P. Burr, Robin Antrobus, Christian Frezza, James A. Nathan · 2020 · Nature Communications
  15. Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma
    Haowen Jiang, Rachel L. Greathouse, Sarah Jane Tiche, Man Zhao, Bo He, Yang Li, Albert Mao Li, Balint Laszlo Forgo, Michaela Yip, Allison Li et al. · 2022 · Cancer Research
  16. Immunometabolism of pro-repair cells
    Benjamin David Singer, Navdeep S. Chandel · 2019 · Journal of Clinical Investigation
  17. Cardiovascular aging: spotlight on mitochondria
    Md Akkas Ali, Rachel A. Gioscia‐Ryan, Dongli Yang, Nadia R. Sutton, Daniel J. Tyrrell · 2023 · American Journal of Physiology-Heart and Circulatory Physiology
  18. Targeting of stress response pathways in the prevention and treatment of cancer
    Jaroslav Zelenka, Martina Koncošová, Tomáš Ruml · 2018 · Biotechnology Advances
  19. Reductive stress in cancer: coming out of the shadows
    Maolin Ge, Thales Y. Papagiannakopoulos, Liron Bar‐Peled · 2023 · Trends in cancer
  20. Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation
    Sergiy M. Nadtochiy, William R. Urciuoli, Jimmy Zhang, Xenia Schafer, Joshua C. Munger, Paul S. Brookes · 2015 · Journal of Molecular and Cellular Cardiology
  21. Roles of IDH1/2 and TET2 mutations in myeloid disorders
    Satoshi Inoue, François Lemonnier, Tak W. Mak · 2016 · International Journal of Hematology
  22. Metabolic Rewiring and the Characterization of Oncometabolites
    Diren Beyoğlu, Jeffrey R. Idle · 2021 · Cancers
  23. Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer
    Pasquale Saggese, Assunta Sellitto, Cesar A. Martinez, Giorgio Giurato, Giovanni Nassa, Francesca Maria Rizzo, Roberta Tarallo, Claudio Scafoglio · 2020 · Cancers
  24. Bridging angiogenesis and immune evasion in the hypoxic tumor microenvironment
    Luana Schito · 2018 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  25. Oncometabolites in cancer aggressiveness and tumour repopulation
    Ilaria Dando, Elisa Dalla Pozza, Giulia Ambrosini, Margalida Torrens‐Mas, Giovanna Butera, Nidula Mullappilly, Raffaella Pacchiana, Marta Palmieri, Massimo Donadelli · 2019 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
  26. Systems Biology Approaches to Redox Metabolism in Stress and Disease States
    Rui‐Sheng Wang, William M. Oldham, Bradley A. Maron, Joseph Loscalzo · 2017 · Antioxidants and Redox Signaling
  27. ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m6A modification-mediated RNA stability control
    Yimeng Gao, Joshua T. Zimmer, Radovan Vasic, Chengyang Liu, Rana Gbyli, Shu-Jian Zheng, Amisha J. Patel, Wei Liu, Zhihong Qi, Yaping Li et al. · 2023 · Cell Reports
  28. Reductive stress in cancer
    Leilei Zhang, Kenneth D. Tew · 2021 · Advances in cancer research
  29. d-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation
    Kyra E. de Goede, Karl J. Harber, Friederike S. Gorki, Sanne G. S. Verberk, Laszlo A. Groh, Eelco D. Keuning, Eduard A. Struys, Michel van Weeghel, Arvand Haschemi, Menno P.J. de Winther et al. · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  30. Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron
    Peter S. J. Bailey, James A. Nathan · 2018 · Biomedicines
  31. Thiol reductive stress activates the hypoxia response pathway
    Ravi Ravi, Ajay Kumar, Shalmoli Bhattacharyya, Jogender Singh · 2023 · The EMBO Journal
  32. MDH1 and MPP7 Regulate Autophagy in Pancreatic Ductal Adenocarcinoma
    Maria I. New, Tim Van Acker, Jun-Ichi Sakamaki, Ming Jiang, Rebecca E. Saunders, Jaclyn S. Long, Victoria M.-Y. Wang, Axel Behrens, Joana Cerveira, Padhmanand Sudhakar et al. · 2019 · Cancer Research
  33. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis
    Xin Teng, Matthew J. Emmett, Mitchell A. Lazar, Erwin Goldberg, Joshua D. Rabinowitz · 2016 · ACS Chemical Biology
  34. Systems Immunology Approaches to Metabolism
    Denis A. Mogilenko, Alexey Sergushichev, Maxim N. Artyomov · 2023 · Annual Review of Immunology
  35. Quantitation of isocitrate dehydrogenase (IDH)-induced D and L enantiomers of 2-hydroxyglutaric acid in biological fluids by a fully validated liquid tandem mass spectrometry method, suitable for clinical applications
    Vianney Poinsignon, Lionel Mercier, Koïchi Nakabayashi, Muriel Daniele David, Alexandre Lalli, Virginie Penard‐Lacronique, Cyril Quivoron, Véronique Saada, Stéphane de Botton, Sophie Broutin et al. · 2016 · Journal of Chromatography B
  36. An l-2-hydroxyglutarate biosensor based on specific transcriptional regulator LhgR
    Zhaoqi Kang, Manman Zhang, Kaiyu Gao, Wen Zhang, Wensi Meng, Yidong Liu, Dan Xiao, Shiting Guo, Cuiqing Ma, Chao Gao et al. · 2021 · Nature Communications
  37. Metabolic Plasticity and Epithelial-Mesenchymal Transition
    Timothy M. Thomson, Cristina Domingo Balcells, Marta Cascante · 2019 · Journal of Clinical Medicine
  38. The Warburg effect: The hacked mitochondrial-nuclear communication in cancer
    Haowen Jiang, Jiangbin Ye · 2025 · Seminars in Cancer Biology
  39. GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis
    Jia‐Shu Yang, Jia‐Wei Hsu, Seung‐Yeol Park, Jian Li, William M. Oldham, Galina V. Beznoussenko, Mironov Aa, Joseph Loscalzo, Victor W. Hsu · 2018 · Nature
  40. Advances into understanding metabolites as signaling molecules in cancer progression
    Joyce Y. Liu, Kathryn E. Wellen · 2020 · Current Opinion in Cell Biology
  41. Pyridine Dinucleotides from Molecules to Man
    Joshua P. Fessel, William M. Oldham · 2017 · Antioxidants and Redox Signaling
  42. ER reductive stress caused by Ero1α S-nitrosation accelerates senescence
    Xinhua Qiao, Yingmin Zhang, Aojun Ye, Yini Zhang, Ting Xie, Zhenyu Lv, Shi Chang, Dongli Wu, Boyu Chu, Xun Wu et al. · 2022 · Free Radical Biology and Medicine
  43. L-2-Hydroxyglutarate Protects Against Cardiac Injury via Metabolic Remodeling
    Huamei He, Ryan M. Mulhern, William M. Oldham, Wusheng Xiao, Yi‐Dong Lin, Ronglih Liao, Joseph Loscalzo · 2022 · Circulation Research
  44. TCA cycle-derived oncometabolites in cancer and the immune microenvironment
    Shukla Sarkar, Chien-I Chang, Jussekia Jean, Meng‐Ju Wu · 2025 · Journal of Biomedical Science
  45. Role of pseudohypoxia in the pathogenesis of type 2 diabetes
    Jing Song, Xiaojuan Yang, Liang‐Jun Yan · 2019 · Hypoxia
  46. Adaptions to Hypoxia and Redox Stress
    Joseph Loscalzo · 2016 · Circulation Research
  47. Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells
    Emily Grace Armitage, Helen L. Kotze, James William Allwood, Warwick B. Dunn, Royston Goodacre, Kaye Janine Williams · 2015 · Scientific Reports
  48. Deciphering the Warburg Effect: Metabolic Reprogramming, Epigenetic Remodeling, and Cell Dedifferentiation
    Albert Mao Li, Jiangbin Ye · 2023 · Annual Review of Cancer Biology
  49. Sulfide oxidation promotes hypoxic angiogenesis and neovascularization
    Roshan Kumar, Victor Vitvitsky, Apichaya Sethaudom, Rashi Singhal, Sumeet A. Solanki, Sydney P. Alibeckoff, Harrison L. Hiraki, Hannah Noelle Bell, Anthony C. Andren, Brendon M. Baker et al. · 2024 · Nature Chemical Biology
  50. Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction
    Sammy Alhassen, Siwei Chen, Lamees Alhassen, Alvin Phan, Mohammad Khoudari, Angele De Silva, Huda Barhoosh, Zitong Wang, Chelsea Marie T. Parrocha, Emily Shapiro et al. · 2021 · Communications Biology
  51. Hypoxic adaptation of mitochondria and its impact on tumor cell function
    Martin Benej, Ioanna Papandreou, Nicholas C. Denko · 2024 · Seminars in Cancer Biology
  52. The flux of energy in critical illness and the obesity paradox
    Ariel Jaitovich, Jesse B. Hall · 2025 · Physiological Reviews
  53. Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells
    Roberto E. Flores, Ashley Kaye Brown, Luke J. Taus, Julianna Khoury, Frank Glover, Kenjiro Kami, Rangaprasad Sarangarajan, Tony E. Walshe, Niven R. Narain, Michael A. Kiebish et al. · 2018 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
  54. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb
    Eileen I. Chang, Stephanie R. Wesolowski, Elizabeth A. Gilje, Peter R. Baker, Julie A. Reisz, Angelo D’Alessandro, William W. Hay, Paul Joseph Rozance, Laura Davidson Brown · 2019 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
  55. MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome
    Zhijun Qiu, An‐Ping Lin, Shoulei Jiang, Sara M. Elkashef, Jamie Myers, Subramanya Srikantan, Binu Kandathilparambil Sasi, John Z. Cao, Lucy A. Godley, Dinesh Rakheja et al. · 2020 · Cell chemical biology
  56. Oncometabolites and the response to radiotherapy
    Kexu Xiang, Verena Jendrossek, Johann Matschke · 2020 · Radiation Oncology
  57. An NADH-selective and sensitive fluorescence probe to evaluate living cell hypoxic stress
    Mingzhe Li, Chang Liu, Wenjuan Zhang, Longfei Xu, Miaomiao Yang, Zhaoli Chen, Xinxing Wang, Lingling Pu, Weili Liu, Xianshun Zeng et al. · 2021 · Journal of Materials Chemistry B
  58. Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension
    Bradley M. Wertheim, Rui‐Sheng Wang, Christelle Guillermier, Christiane V. R. Hütter, William M. Oldham, Jörg Menche, Matthew L. Steinhauser, Bradley A. Maron · 2023 · JCI Insight
  59. Intracellular dehydrogenation catalysis leads to reductive stress and immunosuppression
    Jie Jiang, Huizhen Zheng, Zhenzhen Wang, Xinlian Wang, Qianqian Xie, Xi Liu, Qing Kun Yang, Xiaoming Cai, Xingfa Gao, Ruibin Li et al. · 2025 · Nature Nanotechnology
  60. Regulation of Glutarate Catabolism by GntR Family Regulator CsiR and LysR Family Regulator GcdR in Pseudomonas putida KT2440
    Manman Zhang, Zhaoqi Kang, Xiaoting Guo, Shiting Guo, Dan Xiao, Yidong Liu, Cuiqing Ma, Ping Xu, Chao Gao · 2019 · mBio
  61. GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma
    Zhiqing Fang, Ning Zhang, Xiaotian Yuan, Xiangling Xing, Xiaofeng Li, Xin Qin, Zhengfang Liu, Shiyong Neo, Cheng Liu, Feng Kong et al. · 2022 · Journal of Experimental & Clinical Cancer Research
  62. Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry
    William M. Oldham, Joseph Loscalzo · 2016 · BIO-PROTOCOL
  63. Metabolic Regulation of the Epitranscriptome
    Justin M. Thomas, Pedro J. Batista, Jordan L. Meier · 2019 · ACS Chemical Biology
  64. The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma
    Ana Lameirinhas, Vera Miranda‐Gonçalves, Rui Henrique, Cármen Jerónimo · 2019 · Genes
  65. Visualizing physiological parameters in cells and tissues using genetically encoded indicators for metabolites
    Alejandro San Martín, Robinson Arce‐Molina, Camila Aburto, Felipe Baeza‐Lehnert, L. Felipe Barros, Yasna Contreras‐Baeza, A. Pinilla, Iván Ruminot, Daniela Rauseo, Pamela Y. Sandoval · 2022 · Free Radical Biology and Medicine
  66. Indirect Enantioseparations: Recent Advances in Chiral Metabolomics for Biomedical Research
    Luisa-Gabriela Bogos, Ioana-Ecaterina Pralea, Radu-Cristian Moldovan, Cristina Adela Iuga · 2022 · International Journal of Molecular Sciences
  67. Redox imbalance and hypoxia‐inducible factors: a multifaceted crosstalk
    Ravi Ravi, Jogender Singh · 2025 · FEBS Journal
  68. A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation
    Hongde Li, Alexander J. Hurlburt, Jason M. Tennessen · 2018 · Disease Models & Mechanisms
  69. Redox Regulation of Ion Channels and Receptors in Pulmonary Hypertension
    Laura Weise-Cross, Thomas C. Resta, Nikki L. Jernigan · 2018 · Antioxidants and Redox Signaling
  70. A readily 16O-/18O-isotopically-paired chiral derivatization approach for the quantification of 2-HG metabolic panel by liquid chromatography-Tandem mass spectrometry
    Jia‐Yi Zheng, Xue Song Jiang, Jian‐Liang Zhou, Zi‐Qi Shi, Lifang Liu, Gui-Zhong Xin · 2019 · Analytica Chimica Acta
  71. Oncometabolite 2-hydroxyglutarate regulates anti-tumor immunity
    Mengyuan Cai, Jianyi Zhao, Qiang Ding, Jifu Wei · 2024 · Heliyon
  72. Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells
    Wusheng Xiao, Nishith M. Shrimali, Niv Vigder, William M. Oldham, Clary B. Clish, Huamei He, Samantha J. Wong, Bradley M. Wertheim, Elena Arons, Marcia C. Haigis et al. · 2024 · Nature Metabolism
  73. MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases
    An-Ping Lin, Zhijun Qiu, Purushoth Ethiraj, Binu Sasi, Carine Jaafar, Dinesh Rakheja, Ricardo C. T. Aguiar · 2022 · Leukemia
  74. 2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity
    Meena Kusi, Maryam Zand, Li‐Ling Lin, Meizhen Chen, Anthony Lopez, Chun-Lin Lin, Chiou‐Miin Wang, Nicholas L. L. Lucio, Nameer B. Kirma, Jianhua Ruan et al. · 2022 · Cell Reports
  75. Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease
    Nabil Rabhi, Sarah Anissa Hannou, Philippe Froguel, Jean‐Sébastien Annicotte · 2017 · Frontiers in Endocrinology
  76. Cerebrospinal fluid untargeted metabolomic profiling of aneurysmal subarachnoid hemorrhage: an exploratory study
    Alex Y. Lu, Eyiyemisi C. Damisah, Ethan A. Winkler, Ryan A. Grant, Tore Eid, Ketan R. Bulsara · 2018 · British Journal of Neurosurgery
  77. The Role of Reductive Stress in the Pathogenesis of Endocrine-Related Metabolic Diseases and Cancer
    Mitko I. Mladenov, Iliyana Sazdova, Nikola Hadzi‐Petrushev, Rossitza Konakchieva, Hristo Gagov · 2025 · International Journal of Molecular Sciences
  78. Circulating citric acid cycle metabolites and risk of cardiovascular disease in the PREDIMED study
    José Luis Santos, Miguel Ruiz‐Canela, Cristina Razquín, Clary B. Clish, Marta Guasch‐Ferré, Nancy Babió, Dolores Corella, Enrique Gómez‐Gracia, Miquel Fiol, Ramón Estruch et al. · 2023 · Nutrition Metabolism and Cardiovascular Diseases
  79. Distinct IDH1/2-associated Methylation Profile and Enrichment of TP53 and TERT Mutations Distinguish Dedifferentiated Chondrosarcoma from Conventional Chondrosarcoma
    Josephine Kam Tai K. Dermawan, Khedoujia Nafa, Abhinita S. Mohanty, Yingjuan Xu, Ivelise Rijo, Jacklyn Casanova, Liliana B. Villafania, Jamal K. Benhamida, Ciara Marie Kelly, William D. Tap et al. · 2023 · Cancer Research Communications
  80. Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation
    Joshua S. Stoolman, Rogan A. Grant, Taylor A. Poor, Samuel Edward Weinberg, Karis B. D’Alessandro, Jerica Tan, Jennifer Yuan-Shih Hu, Megan E. Zerrer, Walter A. Wood, Madeline C. Harding et al. · 2024 · Nature Metabolism
  81. Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A
    Mina Dodo, Hiroshi Kitamura, Hiroki Shima, Daisuke Saigusa, Sisca Meida Wati, Nao Ota, Fumiki Katsuoka, Hatsune Chiba, Hiroaki Okae, Takahiro Arima et al. · 2018 · The Journal of Biochemistry
  82. Metabolic regulation of key developmental events during mammalian embryogenesis
    Yuyan Xu, Wei Xie, Jin Zhang · 2025 · Nature Cell Biology
  83. Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle
    Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont et al. · 2022 · Cell Reports
  84. Meta-analysis of NAD(P)(H) quantification results exhibits variability across mammalian tissues
    Dassine Azouaoui, Michael René Choinière, Momtafin Khan, Shahab Sayfi, Simran Jaffer, Selvia Yousef, David A. Patten, Alex E. Green, Keir J. Menzies · 2023 · Scientific Reports
  85. Measurement of 2-hydroxyglutarate enantiomers in serum by chiral gas chromatography-tandem mass spectrometry and its application as a biomarker for IDH mutant gliomas
    Shinji K. Strain, Morris D. Groves, Kelly L. Olino, Mark R. Emmett · 2019 · Clinical mass spectrometry
  86. Complex molecular changes induced by chronic progestogens exposure in roach, Rutilus rutilus
    Gábor Maász, Zita Zrínyi, Péter Takács, Sándor Lovas, Istvan Fodor, Tibor Kiss, Zsolt Pirger · 2017 · Ecotoxicology and Environmental Safety
  87. Spatiotemporal Imaging of Cellular Energy Metabolism with Genetically-Encoded Fluorescent Sensors in Brain
    Zhuo Zhang, Weicai Chen, Yuzheng Zhao, Yi An Yang · 2018 · Neuroscience Bulletin
  88. Dysregulation of 2-oxoglutarate-dependent dioxygenases by hyperglycaemia: does this link diabetes and vascular disease?
    Hannah L.H. Green, Alison C. Brewer · 2020 · Clinical Epigenetics
  89. L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis
    Sho Tabata, Yasushi Kojima, Takeharu Sakamoto, Kaori Igarashi, Ko Umetsu, Takamasa Ishikawa, Akiyoshi Hirayama, Rie Kajino‐Sakamoto, Naoya Sakamoto, Ken‐ichi Yasumoto et al. · 2023 · Oncogene
  90. Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions
    Rachel S. Kelly, Joanne E. Sordillo, Sharon Marie Lutz, Lydiana Ávila, Manuel Soto-Quirós, Juan Carlos Celedon, Michael J. McGeachie, Amber Dahlin, Kelan G. Tantisira, Mengna Huang et al. · 2019 · Metabolites
  91. Reductive Stress: Neglected Science
    Namakkal Soorappan Rajasekaran · 2020 · Antioxidants and Redox Signaling
  92. Interaction between transforming Theileria parasites and their host bovine leukocytes
    Shahin Tajeri, Malak Haidar, Takaya Sakura, Gordon Langsley · 2021 · Molecular Microbiology
  93. Metabolomic Changes in Naturally MAP-Infected Holstein–Friesian Heifers Indicate Immunologically Related Biochemical Reprogramming
    Emma Nicole Taylor, Manfred Beckmann, Bernardo Villarreal‐Ramos, Hans‐Martin Vordermeier, R. Glyn Hewinson, David Rooke, Luis A. J. Mur, Ad P. Koets · 2021 · Metabolites
  94. Physiology of malate dehydrogenase and how dysregulation leads to disease
    Amy Parente, Danielle E. Bolland, Kathryn L. Huisinga, Joseph John Provost · 2024 · Essays in Biochemistry
  95. Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation
    Sergiy M. Nadtochiy, Yves T. Wang, Jimmy Zhang, Keith W. Nehrke, Xenia Schafer, Kevin A. Welle, Sina Ghaemmaghami, Josh Munger, Paul S. Brookes · 2017 · Biochemical Journal
  96. Fermentative Production of l-2-Hydroxyglutarate by Engineered Corynebacterium glutamicum via Pathway Extension of l-Lysine Biosynthesis
    Carina Prell, Arthur Burgardt, Florian Meyer, Volker F. Wendisch · 2021 · Frontiers in Bioengineering and Biotechnology
  97. α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cells
    Kexu Xiang, Mikhail Kunin, Safa Larafa, Maike Anna Busch, Nicole Dünker, Verena Jendrossek, Johann Matschke · 2024 · Cell Death Discovery
  98. Targeted Differentiation Therapy with Mutant IDH Inhibitors: Early Experiences and Parallels with Other Differentiation Agents
    Eytan M. Stein, Katharine E. Yen · 2017 · Annual Review of Cancer Biology
  99. Towards Personalized Antioxidant Use in Female Infertility: Need for More Molecular and Clinical Studies
    Jan Tesařík · 2021 · Biomedicines
  100. Nrf2 sensitizes ferroptosis through L-2-hydroxyglutarate-mediated chromatin modifications in sickle cell disease
    Caixia Xi, Junfeng Pang, Wenbo Zhi, Chang‐Sheng Chang, Umapathy Siddaramappa, Huidong Shi, Anatolij Horuzsko, Betty S. Pace, Xingguo Zhu · 2023 · Blood