Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

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  10. A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia
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  16. 2‐Hydoxyglutarate: D/Riving Pathology in gLiomaS
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  17. Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study
    Zhengliang Peng, Qiong Zhan, Xiangkun Xie, Hanlin Li, Yan Tu, Yujia Bai, Xingfu Huang, Wenyan Lai, Boxin Zhao, Qingchun Zeng et al. · 2019 · Molecular Medicine
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  19. 2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
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  20. Exploiting tumor hypoxia for cancer treatment
    Niemans · 2018 · Research Publications (Maastricht University)
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  23. Pulmonary Comorbidity in Lung Cancer
    Feixiong Cheng, Joseph Loscalzo · 2018 · Trends in Molecular Medicine
  24. Evidence that 2-hydroxyglutarate is not readily metabolized in colorectal carcinoma cells
    Susan J. Gelman, Nathaniel G. Mahieu, Kevin Cho, Elizabeth M. Llufrio, Timothy A. Wencewicz, Gary J. Patti · 2015 · Cancer & Metabolism
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  27. The oncometabolite L-2-hydroxyglutarate is a common product of dipteran larval development
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  33. NMR-based isotope editing, chemoselection and isotopomer distribution analysis in stable isotope resolved metabolomics
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  45. Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis
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    Tigist Y. Tamir, Shreya Chaudhary, Annie X Li, S Trojan, Cameron T. Flower, Paula Vo, Yufei Cui, Jeffrey C Davis, Rachit S Mukkamala, Francesca N Venditti et al. · 2024 · Molecular Cell
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    Zekun Chen, Ming Gao Yu, Zhong-Yao Li, Ling-Li Zheng, Jichao Zhang, Ting-Ting Liu, Zhuo Yang, Lei Li, Zhiyuan Lu, Tiantian Wei et al. · 2026 · ACS Nano
  49. Alternative oxidase blunts pseudohypoxia and photoreceptor degeneration due to RPE mitochondrial dysfunction
    Ming Chen, Yekai Wang, Roopa Dalal, Jianhai Du, Douglas Vollrath · 2024 · Proceedings of the National Academy of Sciences
  50. Metabolomics analysis of annual killifish (Austrofundulus limnaeus) embryos during aerial dehydration stress
    Daniel E. Zajic, Jason E. Podrabsky · 2020 · Physiological Genomics
  51. Normalization of metabolic data to total thymine content and its application to determination of 2-hydroxyglutarate
    Martyna Modrzejewska, Maciej Gawroński, Daniel Gackowski · 2021 · Analytical Biochemistry
  52. Systems approaches to understand oxygen sensing: how multi-omics has driven advances in understanding oxygen-based signalling
    Michael Batie, Niall S. Kenneth, Sónia Rocha · 2022 · Biochemical Journal
  53. Overview of Glutamine Dependency and Metabolic Rescue Protocols
    Shuo Qie, Dan He, Nianli Sang · 2019 · Methods in molecular biology
  54. Acute Myeloid Leukemia
    Fortina P, Londin E, Park JY, Kricka LJ · 2017 · Methods in molecular biology
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    Haowen Jiang, Sarah Jane Tiche, Clifford Jiajun He, Junyan Liu, Fuyun Bian, Mohamed Jedoui, Balint Laszlo Forgo, Md Tauhidul Islam, Meng Zhao, Pamela O. Emengo et al. · 2025 · Proceedings of the National Academy of Sciences
  56. Quantification of d- and l-2-Hydroxyglutarate in Drosophila melanogaster Tissue Samples Using Gas Chromatography-Mass Spectrometry
    Hongde Li, Jason M. Tennessen · 2019 · Methods in molecular biology
  57. Oncometabolites as Regulators of DNA Damage Response and Repair
    Susan E. Gueble, Ranjit S. Bindra · 2021 · Seminars in Radiation Oncology
  58. Resolving Enantiomers of 2-Hydroxy Acids by Nuclear Magnetic Resonance
    Penghui Lin, Daniel R. Crooks, William Marston Linehan, Teresa W.‐M. Fan, Andrew N. Lane · 2022 · Analytical Chemistry
  59. S-2HG is an immunometabolite that shapes the T-cell response
    Rob A. Cairns, Tak W. Mak · 2016 · Cell Death and Differentiation
  60. Challenges of Spatially Resolved Metabolism in Cancer Research
    Andrew N. Lane, Richard M. Higashi, Teresa W.‐M. Fan · 2024 · Metabolites
  61. Reductive stress in cancer immunology and targeted therapy
    Xiaotian Ji, Gang Xiao · 2025 · Acta Biochimica et Biophysica Sinica
  62. An Ultrasensitive Biosensor for Probing Subcellular Distribution and Mitochondrial Transport of l ‐2‐Hydroxyglutarate
    Zhaoqi Kang, Shuang Hou, Kaiyu Gao, Yidong Liu, Ning Zhang, Zhiqing Fang, Wen Zhang, Xianzhi Xu, Rong Xu, Chuanjuan Lü et al. · 2024 · Advanced Science
  63. Roles of the oncometabolite enantiomers of 2-hydroxyglutarate and their metabolism by diverse dehydrogenases
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  66. A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate
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  67. Polystyrene nanoplastics reprogramed pulmonary metabolisms mediated by immune regulation of myeloid hypoxia-inducible factor 1α
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  69. Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite
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  70. Renal L-2-hydroxyglutarate dehydrogenase activity promotes hypoxia tolerance and mitochondrial metabolism in Drosophila melanogaster
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  71. Hypoxic pregnancy promotes fibrosis and increases stress metabolites in the ovine fetal liver
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  72. L2HGDH Missense Variant in a Cat with L-2-Hydroxyglutaric Aciduria
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  73. Suffocation of gene expression
    Dan Ye, Yue Xiong · 2016 · Nature
  74. Metabolomics study of platelet concentrates photochemically treated with amotosalen and UVA light for pathogen inactivation
    Freyr Jóhannsson, Níels Árni Árnason, Ragna Landrö, Sveinn Guðmundsson, Ólafur E. Sigurjónsson, Óttar Rolfsson · 2019 · Transfusion
  75. Systems biology and network medicine: An integrated approach to redox biology and pathobiology
    Laurel Yong-Hwa Lee, Joseph Loscalzo · 2019 · Elsevier eBooks
  76. Fluorescence biomarkers of malignant melanoma detectable in urine
    Ivana Špaková, Katarı́na Dubayová, Vladimíra Nagyová, Mária Mareková · 2020 · Open Chemistry
  77. Quantitative Analysis of Oncometabolite 2-Hydroxyglutarate
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  78. Different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation
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  88. Acidic pH is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling
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  90. 2-hydroxyglutarate controls centromere and heterochromatin conformation and function in the male germline
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  93. A big picture of the mitochondria-mediated signals: From mitochondria to organism
    Neşe Vardar Acar, Rıza Köksal Özgül · 2023 · Biochemical and Biophysical Research Communications
  94. Effects of L-carnitine over-supplementation on spermatogenesis and sperm function in healthy NMRI mice
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  96. Signaling in the tumor microenvironment of therapy-resistant glioblastoma
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  97. Plasma 2-hydroxyglutarate, a promising prognostic biomarker candidate for skeletal muscle injury in Fischer 344 rats
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