The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Why NAD + Declines during Aging: It’s Destroyed
Open accessAbstract
NAD(+) is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD(+) during aging, with implications for combating age-related diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Senescent cells can decrease NAD+ through SASP activation of the NAD-degrading enzyme CD38 on the surface of macrophages and, remarkably, senolytics partially restore tissue NAD+ levels139,140.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [140]
Experimental — accuracy not yet measuredIn the citing paper
“Sirtuin activity and NAD levels both decline with age116,117.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [117]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482
Self-citationYoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340
NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255 · cited 1×
“Observed effects include increased insulin sensitivity, reversal of mitochondrial dysfunction, reduced stem cell senescence, and extension of lifespan (Bai et al., 2011; Gomes et al., 2013; Yoshino et al., 2011; Zhang et al., 2016).”
BackgroundNutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival
Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.035 · Cited by 950
Self-citationCamacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.006 · Cited by 901
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.004 · Cited by 837
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38
Escande, C., Nin, V., Price, N. L., Capellini, V., Gomes, A. P., Barbosa, M. T., O’Neil, L., White, T. A., Sinclair, D. A., & Chini, E. N. (2013) · Diabetes · doi:10.2337/db12-1139 · Cited by 332
Self-citationAnderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O., Cohen, H. Y., Lin, S., Manchester, J. K., Gordon, J. I., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111773200 · Cited by 295
Self-citationHaffner, C. D., Becherer, J. D., Boros, E. E., Cadilla, R., Carpenter, T., Cowan, D., Deaton, D. N., Guo, Y., Harrington, W., Henke, B. R., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm502009h · Cited by 137
Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-α and dexamethasone
Tirumurugaan, K. G., Kang, B. N., Panettieri, R. A., Foster, D. N., Walseth, T. F., & Kannan, M. (2008) · Respiratory Research · doi:10.1186/1465-9921-9-26 · Cited by 50
Flagged first, then by citations
Research works printed but not linked: 1
- Zhang, 2016, Science
Cited by
Sorted by citations
Items 101–125 of 125
DNA methylation and chromatin modifications
Sepehri, Z., Beacon, T. H., Osman, F. D. S., Jahan, S., & Davie, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816843-1.00002-3 · Cited by 8
Revealing the secrets of Blue Zones
Ulusu, N. N. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1428111 · Cited by 9
The intervention on aging system: A classification model, the requirement for five novel categories
Palmer, R. D. (2022) · Aging Medicine · doi:10.1002/agm2.12193 · Cited by 4
Li, Z., Anugula, S., & Rasmussen, L. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823761-8.00020-3 · Cited by 6
Wei, Y., Huang, Y., Wen, C., Wei, K., Peng, L., & Wei, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137686 · Cited by 5
Regenerative Rehabilitation in Sarcopenia, Dynapenia, and Frailty
Baumann, C. W., Clark, B. C., Phillips, B. E., Szewczyk, N. J., & Consitt, L. A. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-95884-8_5 · Cited by 4
Protein Acetylation and NAD+ Homeostasis in Aging Muscle
Ji, L. L. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_17 · Cited by 3
Olvera‐Rojas, M., Plaza‐Florido, A., Solis‐Urra, P., Osuna‐Prieto, F. J., & Ortega, F. B. (2024) · Pediatric Obesity · doi:10.1111/ijpo.13155 · Cited by 3
Diet restriction-induced mitochondrial signaling and healthy aging
Pinkerton, M., & Barrientos, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00027-8 · Cited by 2
Lifespan‐Extending Endogenous Metabolites
Jiang, Y., & Han, J. J. (2026) · Aging Cell · doi:10.1111/acel.70371 · Cited by 1
烟酰胺腺嘌呤二核苷酸（NAD+）合成代谢及其调控机体衰老研究进展
Li, Y., Tian, X., Luo, J., Bao, T., & Wu, X. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0004
Serbezov, D., Balabanski, L., Karachanak-Yankova, S., Vazharova, R., Nesheva, D. V., Hammoudeh, Z., Staneva, R., Mihaylova, M., Damyanova, V., Antonova, O., et al. (2020) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2020.41 · Cited by 1
When Will the FDA Do What Is in People’s Best Interests?
Ordman, A. B. (2022) · American Journal of Economics and Sociology · doi:10.1111/ajes.12481
Mechanism of Niacin Induced Hot Flushes and Suppression of Cholesterol
Subramanian, T. (2023) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2023.115016
Bai, X., & Wang, P. (2021) · Research Square · doi:10.21203/rs.3.rs-961019/v1
He, Z., Lyu, J., Lyu, L., Long, X., & Xu, B. (2024) · Medicine · doi:10.1097/md.0000000000038347
Reece, A. S., & Hulse, G. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13492-0.00027-x
Nicotinamide (Vitamin B3 ) Deficiency in Follicular Fluid of Patients With Ovarian Ageing
Bocca, C., Boguenet, M., Boucret, L., Bouet, P., Reynier, P., & May‐Panloup, P. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71085
DNA methylation and chromatin modifications-updates based on chromatin modifiers
Sepehri, Z., Beacon, T. H., Osman, F. D. S., Jahan, S., & Davie, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-15572-7.00002-4
Tang, X.-Y., Lu, K.-J., Zhu, R., Gao, Y., Wei, D.-Y., Zhang, X.-Y., S, Y., Wang, F.-F., & Zou, C. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070661
The role of exercise in modulating NAD+ metabolic enzymes: mechanisms and health benefits
Anas, Sundus, H., Khan, S. A., Ahmed, S. S., Muruganantham, P., & Madar, I. H. (2026) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2026.1863337
Non-clinical safety evaluation of coenzyme I (NAD⁺): A GLP-compliant systematic study
Gu, J., Xu, J., Yang, S., Qiu, Y., Yin, L., & Xu, N. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119934
Zhu, J., Li, J., Qin, Y., Cui, Y., & Mou, L. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuag128
Wei, F., Ngo, C., Neal, C. J., Schwartzman, J. D., Pugazhendhi, A. S., Omer, M., Walck, C. D., Seal, S., & Coathup, M. J. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156794
Harvey, J. R. M., Wight, T. H., Roberts, M., Mulligan, V. J., Barker, D. F., Sherlock, C., Ossola, B., Hewer, R., Xu, X., Page, K. J., et al. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1927552
Metadata
- Authors
- Schultz, M. B., & Sinclair, D. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Sinclair, David A.
- ORCID
- Sinclair, David A.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 23
- Issue
- 6
- Pages
- 965-966
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5088772
- OpenAlex
- W2423823537
- Cited by
- 126
- References
- 10
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 14 · 2023: 14 · 2022: 22 · 2021: 25 · 2020: 16 · 2019: 12 · 2018: 6 · 2017: 3 · 2016: 1
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R37AG028730)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100263)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- aging, CD38, NAD+ metabolism, age-related diseases, sirtuins, NAD+ salvage pathway
- MeSH terms
- Aging, Animals, Mitochondria, Models, Biological, NAD, Mice, ADP-ribosyl Cyclase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
