Cited by 126Sirtuins and Resveratrol in MedicineBiochemical and Molecular ResearchGenetics, Aging, and Longevity in Model Organisms

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Why NAD + Declines during Aging: It’s Destroyed

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Schultz, Michael B., Sinclair, David A.·2016·Cell Metabolism

DOI 10.1016/j.cmet.2016.05.022PMC PMC5088772

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Abstract

NAD(+) is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD(+) during aging, with implications for combating age-related diseases.

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Authors: Schultz, M. B., & Sinclair, D. A.
Affiliations: Harvard University (US)
Corresponding author: Sinclair, David A.
ORCID: Sinclair, David A.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2016-06
Volume: 23
Issue: 6
Pages: 965-966
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2016.05.022
PMC: PMC5088772
OpenAlex: W2423823537
Cited by: 126
References: 10
Citations by year: 2026: 9 · 2025: 4 · 2024: 14 · 2023: 14 · 2022: 22 · 2021: 25 · 2020: 16 · 2019: 12 · 2018: 6 · 2017: 3 · 2016: 1
FWCI: 4.21
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R37AG028730)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK100263)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: aging, CD38, NAD+ metabolism, age-related diseases, sirtuins, NAD+ salvage pathway
MeSH terms: Aging, Animals, Mitochondria, Models, Biological, NAD, Mice, ADP-ribosyl Cyclase 1

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Why NAD + Declines during Aging: It’s Destroyed

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