Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation
Ron-Harel, Noga, Santos, Daniel, Ghergurovich, Jonathan M., Sage, Peter T., Reddy, Anita, Lovitch, Scott B., Dephoure, Noah, Satterstrom, F. Kyle +6 more·2016·Cell Metabolism
Cited by (430)
Items 101–200 of 430
- Fueling T-cell Antitumor Immunity: Amino Acid Metabolism RevisitedChenfeng Han, Minmin Ge, Ping‐Chih Ho, Lianjun Zhang · 2021 · Cancer Immunology Research
- A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammationLiuhui Fu, Jie Zhao, Jiaoyan Huang, Na Li, Xin Zhou Dong, Yao He, Wenyan Wang, Yu Wang, Ju Qiu, Xiaohuan Guo · 2021 · Journal of Allergy and Clinical Immunology
- Mitochondrial heterogeneity in diseasesLong Chen, Mengnan Zhou, Hao Li, Delin Liu, Peng Liao, Zong Yao, Changqing Zhang, Weiguo Zou, Junjie Gao · 2023 · Signal Transduction and Targeted Therapy
- Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesisMatthew Hunt, Mónica S. Torres, Etty Bachar-Wikström, Jakob D. Wikström · 2023 · Frontiers in Cell and Developmental Biology
- Mitochondrial immune regulation and anti-tumor immunotherapy strategies targeting mitochondriaRilan Bai, Jiuwei Cui · 2023 · Cancer Letters
- The metabolic spectrum of memory T cellsDavid O’Sullivan · 2019 · Immunology and Cell Biology
- The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular FunctionYuwen Xiu, Martha S. Field · 2020 · Current Developments in Nutrition
- Metabolic Consequences of T-cell Costimulation in Anticancer ImmunityÁlvaro Teijeira, Saray Garasa, Iñaki Etxeberría, María Gato, Ignacio Melero, Greg M. Delgoffe · 2019 · Cancer Immunology Research
- Inhibition of lactate transport by MCT-1 blockade improves chimeric antigen receptor T-cell therapy against B-cell malignanciesErnesto López, Rajesh Karattil, Francesco Nannini, Gordon Weng-Kit Cheung, Lilian Denzler, Felipe Gálvez‐Cancino, Sergio A. Quezada, Martin A. Pulè · 2023 · Journal for ImmunoTherapy of Cancer
- Metabolic checkpoints in immune cell reprogramming: rewiring immunometabolism for cancer therapyYingying Lv, Zhongxin Li, Shutong Liu, Zhaokai Zhou, Song Jinling, Yuhao Ba, Siyuan Weng, Anning Zuo, Hui Wen Xu, Peng Luo et al. · 2025 · Molecular Cancer
- Mitochondria: A master regulator in macrophage and T cell immunityPu-Ste Liu, Ping‐Chih Ho · 2017 · Mitochondrion
- Alterations in mitochondrial morphology as a key driver of immunity and host defenceMariana P. Cervantes‐Silva, Shannon L. Cox, Annie M. Curtis · 2021 · EMBO Reports
- The effects of age and systemic metabolism on anti-tumor T cell responsesDrijvers, Jefte M, Sharpe, Arlene H, Haigis, Marcia C · 2020 · eLife
- Targeting Drp1 and mitochondrial fission for therapeutic immune modulationLuca Simula, Michelangelo Campanella, Silvia Campello · 2019 · Pharmacological Research
- The emerging role for metabolism in fueling neutrophilic inflammationTyler Morrison, Emily Watts, Pranvera Sadiku, Sarah R. Walmsley · 2022 · Immunological Reviews
- Glycine homeostasis requires reverse SHMT fluxMatthew J. McBride, Craig J. Hunter, Zhaoyue Zhang, Tara A. TeSlaa, Xincheng Xu, Gregory S. Ducker, Joshua D. Rabinowitz · 2024 · Cell Metabolism
- Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammationQing Li, Rodrigo de Oliveira Formiga, Virginie Puchois, Laura Creusot, Ahmad Haidar Ahmad, Salomé Amouyal, Márcio A. C. Ribeiro, Yining Zhao, Danielle M M Harris, Frederic Lasserre et al. · 2025 · Nature Metabolism
- Sculpting tumor microenvironment with immune system: from immunometabolism to immunoeditingY-R Yu, Ping‐Chih Ho · 2019 · Clinical & Experimental Immunology
- Molecular Mechanisms of Alcohol-Induced Colorectal CarcinogenesisCaroline Helen Johnson, Jaya Prakash Golla, Evangelos Dioletis, Surendra Pratap Singh, Momoko Ishii, Georgia Charkoftaki, David C. Thompson, Vasilis Vasiliou · 2021 · Cancers
- Fever supports CD8 + effector T cell responses by promoting mitochondrial translationDavid O’Sullivan, Michal A. Stanczak, Matteo Villa, Franziska Maria Uhl, Mauro Corrado, Ramon I. Klein Geltink, David E. Sanin, Petya Apostolova, Nisha Rana, Joy Edwards-Hicks et al. · 2021 · Proceedings of the National Academy of Sciences
- Systems-based approaches to study immunometabolismVinee Purohit, Allon Wagner, Nir Yosef, Vijay Kumar Kuchroo · 2022 · Cellular and Molecular Immunology
- Importance of Energy, Dietary Protein Sources, and Amino Acid Composition in the Regulation of Metabolism: An Indissoluble Dynamic Combination for LifeGiovanni Corsetti, Evasio Pasini, Tiziano Maria Scarabelli, Claudia Romano, Arashpreet Singh, Carol Chen-Scarabelli i Tiziano M. Scarabelli, Francesco Saverio Dioguardi · 2024 · Nutrients
- Mechanisms and Functions of Mitophagy and Potential Roles in Renal DiseaseZhenying Zuo, Kaipeng Jing, Hong-Luan Wu, Shujun Wang, Lin Ye, Zhihang Li, Chen Yang, Qingjun Pan, Wei Jing Liu, Huafeng Liu · 2020 · Frontiers in Physiology
- The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagyJian Chen, Risi Na, Chao Wu Xiao, Xiao Wang, Yupeng Wang, Dongwang Yan, Guohe Song, Xueni Liu, Jiayi Chen, Huijun Lu et al. · 2021 · Oncogene
- Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapyYana Pikman, Nicole Ocasio-Martinez, Gabriela Alexe, Boris Dimitrov, Samuel Kitara, Frances F. Diehl, Amanda L. Robichaud, Amy Saur Conway, Linda S. Ross, Angela H. Su et al. · 2021 · Leukemia
- Cycling back to folate metabolism in cancerYounghwan Lee, Karen H. Vousden, Marc Hennequart · 2024 · Nature Cancer
- Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 BlockadeRowe, Jared H., Elia, Ilaria, Shahid, Osmaan, Gaudiano, Emily F., Sifnugel, Natalia E., Johnson, Sheila, Reynolds, Amy G., Fung, Megan E., Joshi, Shakchhi, LaFleur, Martin W. et al. · 2023 · Cancer Discovery
- The bidirectional relationship between metabolism and cell cycle controlFrances F. Diehl, Kiera M. Sapp, Matthew G. Vander Heiden · 2023 · Trends in Cell Biology
- 13 C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8 T cellsEric H. Ma, Michael S. Dahabieh, Lisa M. DeCamp, Irem Kaymak, Susan M. Kitchen-Goosen, Brandon M. Oswald, Joseph Longo, Dominic Guy Roy, Mark J. Verway, Radia Marie Johnson et al. · 2024 · Science Advances
- The Importance of Metabolism for Immune Homeostasis in Allergic DiseasesJuan Rodríguez‐Coira, Alma Villaseñor, Elena Izquierdo, Mengting Huang, Tomás Clive Barker‐Tejeda, Urszula Radzikowska, Milena Sokołowska, Domingo Barber · 2021 · Frontiers in Immunology
- Mitochondria during T cell agingJosé Ignacio Escrig-Larena, Sandra Delgado-Pulido, Marı́a Mittelbrunn · 2023 · Seminars in Immunology
- Systems immunology: Integrating multi-omics data to infer regulatory networks and hidden drivers of immunityJiyang Yu, Junmin Peng, Hongbo Chi · 2019 · Current Opinion in Systems Biology
- mTOR signaling in immune cells and its implications for cancer immunotherapyHu Zeng · 2017 · Cancer Letters
- Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethalHaruna Tani, Sakiko Ohnishi, Hiroshi Shitara, Takayuki Mito, Midori Yamaguchi, Hiromichi Yonekawa, Osamu Hashizume, Kaori Ishikawa, Kazuto Nakada, Jun‐Ichi Hayashi · 2018 · Scientific Reports
- The clock is ticking: the impact of ageing on T cell metabolismKylie M. Quinn, Riya Palchaudhuri, Clovis Steve Palmer, Nicole L. La Gruta · 2019 · Clinical & Translational Immunology
- Rewiring Mitochondrial Metabolism for CD8+ T Cell Memory Formation and Effective Cancer ImmunotherapyWenhui Li, Lianjun Zhang · 2020 · Frontiers in Immunology
- Immunometabolism of CD8+ T cell differentiation in cancerHao Shi, Sidi Chen, Hongbo Chi · 2024 · Trends in cancer
- Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell ActivationBillur Akkaya, Alexander Scott Roesler, Pietro Miozzo, Brandon P. Theall, Jafar A Al Souz, Margery G. Smelkinson, Juraj Kabát, Javier Traba, Michael N. Sack, Joseph A. Brzostowski et al. · 2018 · The Journal of Immunology
- Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fateElizabeth M. Steinert, Beatriz Furtado Bruza, Veronika Denise Danchine, Rogan A. Grant, Karthik Vasan, Arjun Kharel, Yuqi Zhang, Weiguo Cui, Marten Szibor, Samuel Edward Weinberg et al. · 2025 · Nature Immunology
- Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to ProliferationHo‐Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh‐Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas Andreas Lyssiotis et al. · 2017 · Cell Reports
- SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagyMuyu Xu, James J. Moresco, Max W. Chang, Amey Mukim, Davey Mitchell Smith, Jolene K. Diedrich, John R. Yates, Katherine A. Jones · 2018 · PLoS Pathogens
- Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamicsAna Victoria Lechuga‐Vieco, Ana Latorre, Iain G. Johnston, Gennaro Prota, Uzi Gileadi, Raquel Justo‐Méndez, Rebeca Acín‐Pérez, Raquel Martínez de Mena, Jose María Fernández-Toro, Daniel Jiménez-Blasco et al. · 2020 · Science Advances
- Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16Ruili Yang, He Huang, C.S. Han, Shengjie Cui, Yan-Heng Zhou, Yanyan Zhou · 2020 · Journal of Dental Research
- The role of mitochondria in tumor metastasis and advances in mitochondria-targeted cancer therapyFanglu Chen, Yucheng Xue, Wenkan Zhang, Hao Zhou, Zhiyi Zhou, Tao Chen, Eloy Yinwang, Hengyuan Li, Zhaoming Ye, Junjie Gao et al. · 2024 · Cancer and Metastasis Reviews
- mTOR Overcomes Multiple Metabolic Restrictions to Enable HIV-1 Reverse Transcription and Intracellular TransportHarry E. Taylor, Nina Calantone, Drew Lichon, Hannah Hudson, Isabelle Clerc, Edward M. Campbell, Richard T. D’Aquila · 2020 · Cell Reports
- Immunometabolism in the Tumor MicroenvironmentDominic Guy Roy, Irem Kaymak, Kelsey S. Williams, Eric H. Ma, Russell G. Jones · 2020 · Annual Review of Cancer Biology
- Metabolic engineering for optimized CAR-T cell therapySarah J. McPhedran, Gillian A. Carleton, Julian J. Lum · 2024 · Nature Metabolism
- Mitochondria: the gatekeepers between metabolism and immunityGiovanna Trinchese, Fabiano Cimmino, Angela Catapano, Gina Cavaliere, Maria Pina Mollica · 2024 · Frontiers in Immunology
- Linking Serine/Glycine Metabolism to Radiotherapy ResistanceAnaís Sánchez‐Castillo, Marc Vooijs, Kim Rosalie Kampen · 2021 · Cancers
- T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responsesKoji Toriyama, Makoto Kuwahara, Hiroshi Kondoh, Takumi Mikawa, Nobuaki Takemori, Amane Konishi, Toshihiro Yorozuya, Takeshi Yamada, Tomoyoshi Soga, Atsushi Shiraishi et al. · 2020 · Communications Biology
- Pyruvate kinase M2 activation reprograms mitochondria in CD8 T cells, enhancing effector functions and efficacy of anti-PD1 therapySeyedeh Sahar Mortazavi Farsani, Jignesh Soni, Jin Lu, Anil Kumar Yadav, Shivani Bansal, Tian Mi, Leena A Hilakivi-Clarke, Robert C. Clarke, Ben Youngblood, Amrita K. Cheema et al. · 2025 · Cell Metabolism
- Mitochondrial Control and Guidance of Cellular Activities of T CellsTung Hui Chao, Haiping Wang, Ping‐Chih Ho · 2017 · Frontiers in Immunology
- Role of mitochondrial dysfunction on rheumatic diseasesCarlos Vaamonde‐García, María José López-Armada · 2019 · Biochemical Pharmacology
- The Role of Metabolic Enzymes in the Regulation of InflammationWesley H. Godfrey, Michael D. Kornberg · 2020 · Metabolites
- Nutrients in Energy and One-Carbon Metabolism: Learning from Metformin UsersFedra Luciano‐Mateo, Anna Hernández‐Aguilera, Noemí Cabré, Jordi Camps, Salvador Fernández‐Arroyo, José López‐Miranda, Javier Abel Menéndez, Jorge Joven · 2017 · Nutrients
- T cells at work: How post‐transcriptional mechanisms control T cell homeostasis and activationAnouk P. Jurgens, Branka Popović, Monika C. Wolkers · 2021 · European Journal of Immunology
- ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasisMarc Hennequart, Steven E. Pilley, Christiaan F. Labuschagne, Jack Coomes, Loïc Mervant, Paul C. Driscoll, Nathalie Michelle Legrave, Younghwan Lee, Peter A. Kreuzaler, Benedict Macintyre et al. · 2023 · Cell Reports
- The role of metabolic states in development and diseaseMatthew Sieber, Allan C. Spradling · 2017 · Current Opinion in Genetics & Development
- Macrophages rely on extracellular serine to suppress aberrant cytokine productionKento Kurita, Hiroya Ohta, Ibuki Shirakawa, Miyako Tanaka, Yasuyuki Kitaura, Yorihiro Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Seiichiro Aoe, Hiroshi Arima et al. · 2021 · Scientific Reports
- Metabolic rewiring and communication in cancer immunityNicole M. Chapman, Hongbo Chi · 2024 · Cell chemical biology
- Early effector maturation of naïve human CD8+ T cells requires mitochondrial biogenesisMarco Fischer, Glenn R. Bantug, Sarah Dimeloe, Patrick M. Gubser, Anne-Valérie Burgener-Gasser, Jasmin Grählert, Maria Luisa Balmer, Leyla Develioglu, Rebekah Steiner, Gunhild Unterstab et al. · 2018 · European Journal of Immunology
- Age-related changes in B cell metabolismRaj K. Kurupati, Larissa Herkenhoff Haut, Kenneth E. Schmader, Hildegund C.J. Ertl · 2019 · Aging
- Metabolomic differences of exhaled breath condensate among children with and without asthmaJu Chang‐Chien, Hsin‐Yi Huang, Hui‐Ju Tsai, Chi‐Jen Lo, Wan‐Chen Lin, Yu‐Lun Tseng, Shih‐Ling Wang, Hung‐Yao Ho, Mei‐Ling Cheng, Tsung‐Chieh Yao · 2020 · Pediatric Allergy and Immunology
- CD4+ T cell metabolism, gut microbiota, and autoimmune diseases: implication in precision medicine of autoimmune diseasesWenjing Yang, Tianming Yu, Yingzi Cong · 2022 · Precision Clinical Medicine
- Platelet factor 4 enhances CD4+ T effector memory cell responses via Akt‐PGC1α‐TFAM signaling‐mediated mitochondrial biogenesisShuai Tan, Shuijie Li, Yanan Min, Anton Gisterå, Noah Moruzzi, Junhao Zhang, Yang Sun, John Andersson, Rickard E. Malmström, Miao Wang et al. · 2020 · Journal of Thrombosis and Haemostasis
- New Immunometabolic Strategy Based on Cell Type-Specific Metabolic Reprogramming in the Tumor Immune MicroenvironmentJi‐Yong Sung, Jae‐Ho Cheong · 2022 · Cells
- NetBID2 provides comprehensive hidden driver analysisDong, Xinran, Ding, Liang, Thrasher, Andrew, Wang, Xinge, Liu, Jingjing, Pan, Qingfei, Rash, Jordan, Dhungana, Yogesh, Yang, Xu, Risch, Isabel et al. · 2023 · Nature Communications
- Metabolic imbalance of T cells in COVID-19 is hallmarked by basigin and mitigated by dexamethasonePeter J. Siska, Sonja-Maria Decking, Nathalie Babl, Carina Matos, Christina Bruss, Katrin Singer, Jana Klitzke, Marian Schön, Jakob Simeth, Josef Köstler et al. · 2021 · Journal of Clinical Investigation
- Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxideSteven V John, Gretchen L. Seim, Billy Joel Erazo Flores, James A. Votava, Uzziah S. Urquiza, Nicholas L. Arp, John Steill, Jack Freeman, Lauren N. Carnevale, Isaiah Roberts et al. · 2025 · Nature Metabolism
- Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular functionSarah MacPherson, Sarah Keyes, Marisa K. Kilgour, Julian Smazynski, Vanessa Chan, Jessica Sudderth, Tim Turcotte, Adria Devlieger, Jessie Zexi Yu, Kimberly S. Huggler et al. · 2022 · Molecular Therapy — Methods & Clinical Development
- Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomesPriyanka Nanjireddy, Scott H. Olejniczak, Nataliya Prokopenko Buxbaum · 2023 · Frontiers in Immunology
- Predicting T‐cell quality during manufacturing through an artificial intelligence‐based integrative multiomics analytical platformValerie Y. Odeh‐Couvertier, Nathan J. Dwarshuis, Maxwell B. Colonna, Bruce L. Levine, Arthur S. Edison, Theresa Kotanchek, Krishnendu Roy, Wandaliz Torres‐García · 2021 · Bioengineering & Translational Medicine
- Surveying the Metabolic and Dysfunctional Profiles of T Cells and NK Cells in Myalgic Encephalomyelitis/Chronic Fatigue SyndromeJessica Maya · 2023 · International Journal of Molecular Sciences
- Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancyGiuseppe Lonetto, Gabriela Koifman, Alon Silberman, Ayush Attery, Hilla Solomon, Smadar Levin‐Zaidman, Naomi Goldfinger, Ziv Porat, Ayelet Erez, Varda Rotter · 2018 · Cell Death and Differentiation
- DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolismAlessandra Maresca, Valentina Del Dotto, Mariantonietta Capristo, Emanuela Scimonelli, Francesca Tagliavini, Luca Morandi, Concetta Valentina Tropeano, Leonardo Caporali, Susan Mohamed, Marina Roberti et al. · 2020 · Human Molecular Genetics
- Circles of Life: linking metabolic and epigenetic cycles to immunityChan‐Wang Jerry Lio, Stanley Ching‐Cheng Huang · 2020 · Immunology
- Mitochondrial dysfunctions in T cells: focus on inflammatory bowel diseaseHoyul Lee, Jae‐Han Jeon, Eun Soo Kim · 2023 · Frontiers in Immunology
- PET/CT metabolic patterns in systemic immune activation: A new perspective on the assessment of immunotherapy response and efficacyPeng Jin, Jianing Li, Yingtao Meng, Leilei Wu, Menglin Bai, Jinming Yu, Xue Meng · 2021 · Cancer Letters
- One-carbon metabolism shapes T cell immunity in cancerYajing Qiu, Ermei Xie, Haipeng Xu, Hongcheng Cheng, Guideng Li · 2024 · Trends in Endocrinology and Metabolism
- Kv1.3 channel blockade with the Vm24 scorpion toxin attenuates the CD4+ effector memory T cell response to TCR stimulationJosé Ignacio Veytia‐Bucheli, Juana María Jiménez-Vargas, Erika Melchy-Pérez, Monserrat Alba Sandoval-Hernández, Lourival Domingos Possani, Yvonne Rosenstein · 2018 · Cell Communication and Signaling
- Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus ReplicationNing Tang, Pingyi Chen, Changrun Zhao, Panrao Liu, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Xiufan Liu, Tingrong Luo et al. · 2023 · Journal of Virology
- How Does Inflammation‐Induced Hyperglycemia Cause Mitochondrial Dysfunction in Immune Cells?Gustav van Niekerk, Tanja Davis, Hugh‐G. Patterton, Anna‐Mart Engelbrecht · 2019 · BioEssays
- Ncoa2 Promotes CD8+ T cell–Mediated Antitumor Immunity by Stimulating T-cell Activation via Upregulation of PGC-1α Critical for Mitochondrial FunctionXiancai Zhong, Hongmin Wu, Ching Ouyang, Wencan Zhang, Yun Shi, Yi-Chang Wang, David Kong Ann, Yousang Gwack, Weirong Shang, Zuoming Sun · 2023 · Cancer Immunology Research
- The emerging role of one-carbon metabolism in T cellsHenry Kurniawan, Takumi Kobayashi, Dirk Brenner · 2021 · Current Opinion in Biotechnology
- Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)—T CellsSeyed Mohammad Ali Hosseini Rad, Joshua Colin Halpin, Mojtaba Mollaei, Samuel WJ Smith‐Bell, Nattiya Hirankarn, Alexander Donald McLellan · 2021 · Cancers
- Putative role of STING-mitochondria associated membrane crosstalk in immunityChenyu Xue, Na Dong, Anshan Shan · 2022 · Trends in Immunology
- A Treg-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liverChenbo Ding, Zhibin Yu, Esen Sefik, Jing Zhou, Eleanna Kaffe, Gaoyang Wang, Bin Li, Richard Anthony Flavell, Weiguo Hu, Youqiong Ye et al. · 2023 · Nature Aging
- Tumor hypermetabolism confers resistance to immunotherapyArthur J. Liu, Michael A. Curran · 2020 · Seminars in Cancer Biology
- The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and FunctionYashwanth Subbannayya, Markus Haug, Sneha Maria Pinto, Varshasnata Mohanty, Hany Zakaria Meås, Trude Helen Flo, Thottethodi Subrahmanya Keshava Prasad, Richard K. Kandasamy · 2020 · International Journal of Molecular Sciences
- Harnessing Metabolic Reprogramming to Improve Cancer ImmunotherapyYan Liang, Yanlian Tan, Guo Chen, Jun Fan, Jun Zhang · 2021 · International Journal of Molecular Sciences
- Harnessing the Induction of CD8+ T-Cell Responses Through Metabolic Regulation by Pathogen-Recognition-Receptor Triggering in Antigen Presenting CellsFrancesco Nicoli, Stéphane Paul, Victor Appay · 2018 · Frontiers in Immunology
- Metabolic Control of Memory T-Cell Generation and StemnessJana L. Raynor, Nicole M. Chapman, Hongbo Chi · 2021 · Cold Spring Harbor Perspectives in Biology
- MTHFD2 in healthy and cancer cells: Canonical and non-canonical functionsNatalia Pardo Lorente, Sara Sdelci · 2024 · npj Metabolic Health and Disease
- Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cellLouise S. Matheson, Georg Petkau, Beatriz Sáenz‐Narciso, Vanessa D’Angeli, Jessica McHugh, Rebecca Newman, Haydn Munford, James A. West, Krishnendu Chakraborty, Jennie Roberts et al. · 2022 · Scientific Reports
- Autophagy-dependent glutaminolysis drives superior IL21 production in HIV-1-specific CD4 T cellsHamza Loucif, Xavier Dagenais-Lussier, Daina Zofija Avizonis, Luc Choinière, Cherifa Beji, Léna Cassin, Jean‐Pierre Routy, Jörg Hermann Fritz, David P. Olagnier, Julien van Grevenynghe · 2021 · Autophagy
- Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseasesLiyan Lin, Ruyu Ren, Qiao Xiong, Chunfu Zheng, Bin Yang, Huiqing Wang · 2024 · Autoimmunity Reviews
- Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activityRongchuan Zhao, Jiao Yang, Yunjiao Zhai, Hong Zhang, Yuanshuai Zhou, Lei Hong, Detian Yuan, Ruilong Xia, Yanxiang Liu, Jinlin Pan et al. · 2024 · Nature Immunology
- Mitochondrial rewiring with small-molecule drug-free nanoassemblies unleashes anticancer immunityLulu Ren, Jianqin Wan, Xiaoyan Li, Jie Yao, Yan Ma, Fanchao Meng, Shusen Zheng, Weidong Han, Hangxiang Wang · 2024 · Nature Communications
- Tumor Metabolism as a Regulator of Tumor–Host Interactions in the B-Cell Lymphoma Microenvironment—Fueling Progression and Novel Brakes for TherapyAnna C. Beielstein, Christian Philipp Pallasch · 2019 · International Journal of Molecular Sciences
- Pivotal role of exogenous pyruvate in human natural killer cell metabolismNicolas Kern Coquillat, Louis Picq, Ameline Hamond, Pierre Megy, Sarah Benezech, Annabelle Drouillard, Nina Lager-Lachaud, Edern Cahoreau, Marielle Moreau, Lucie Fallone et al. · 2025 · Nature Metabolism