Never waste a good crisis: confronting reproducibility in translational research

Drucker, Daniel J.

doi:10.1016/j.cmet.2016.08.006

Cited by 117Animal testing and alternativesAcademic Publishing and Open AccessResearch Data Management Practices

Never waste a good crisis: confronting reproducibility in translational research

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Drucker, Daniel J.·2016·Cell Metabolism

DOI 10.1016/j.cmet.2016.08.006

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Abstract

The lack of reproducibility of preclinical experimentation has implications for sustaining trust in and ensuring the viability and funding of the academic research enterprise. Here I identify problematic behaviors and practices and suggest solutions to enhance reproducibility in translational research.

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The necessity for enhancement of result reproducibility in the life sciences has been identified and is gradually being internalized by researchers and institutions alike.
“The necessity for enhancement of result reproducibility in the life sciences has been identified and is gradually being internalized by researchers and institutions alike (Prinz et al., 2011; Drucker, 2016).”
From In Vitro research Reproducibility: Keeping up High Standards (2019) · cites this paper as Drucker, 2016
The paper says reproducibility issues in basic science are now debated regularly and describes increasing recognition of the value of questioning results (Abstract; page unavailable). It clearly identifies a need for improvement, but its proposals for funding agencies and scientific meetings do not establish that researchers and institutions alike are gradually internalizing that need. (LLM, conf=0.82)
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Authors: Drucker, D. J.
Affiliations: Mount Sinai Hospital (CA)
Corresponding author: Drucker, Daniel J.
ORCID: Drucker, Daniel J.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2016-09
Volume: 24
Issue: 3
Pages: 348-360
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2016.08.006
OpenAlex: W2518883904
Cited by: 117
References: 19
Citations by year: 2026: 3 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 17 · 2020: 14 · 2019: 26 · 2018: 14 · 2017: 10 · 2016: 3
FWCI: 23.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 377 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Veterinary › Small Animals › Animal testing and alternatives
Social Sciences › Decision Sciences › Information Systems and Management › Academic Publishing and Open Access
Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
Keywords: reproducibility, translational research, preclinical research, research integrity, research misconduct, research funding, public trust in science, research practices
MeSH terms: Animals, Communication, Publishing, Reproducibility of Results, Models, Animal, Animal Experimentation, Biomedical Research, Mice, Translational Research, Biomedical, Research Report

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Never waste a good crisis: confronting reproducibility in translational research

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