The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise
Open accessAbstract
Exercise stimulates the release of molecules into the circulation, supporting the concept that inter-tissue signaling proteins are important mediators of adaptations to exercise. Recognizing that many circulating proteins are packaged in extracellular vesicles (EVs), we employed quantitative proteomic techniques to characterize the exercise-induced secretion of EV-contained proteins. Following a 1-hr bout of cycling exercise in healthy humans, we observed an increase in the circulation of over 300 proteins, with a notable enrichment of several classes of proteins that compose exosomes and small vesicles. Pulse-chase and intravital imaging experiments suggested EVs liberated by exercise have a propensity to localize in the liver and can transfer their protein cargo. Moreover, by employing arteriovenous balance studies across the contracting human limb, we identified several novel candidate myokines, released into circulation independently of classical secretion. These data identify a new paradigm by which tissue crosstalk during exercise can exert systemic biological effects.
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Cites
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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
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Cited by
The compelling link between physical activity and the body's defense system
Nieman, D. C., & Wentz, L. M. (2019) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2018.09.009 · Cited by 1,340
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
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“Exerkines may be released within extracellular vesicles known as exosomes (10), which may contain nucleic acids, peptides, messenger ribonucleic acid (mRNA), microRNA and mitochondrial deoxyribonucleic acid.”
BackgroundPhysical activity and muscle-brain crosstalk
Pedersen, B. K. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0174-x · Cited by 772
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Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Duggal, N. A., Niemiro, G., Harridge, S. D. R., Simpson, R. J., & Lord, J. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0177-9 · Cited by 436
Metadata
- Authors
- Whitham, M., Parker, B. L., Friedrichsen, M., Hingst, J. R., Hjorth, M., Hughes, W. E., Egan, C. L., Cron, L., Watt, K. I., Kuchel, R. P., Jayasooriah, N., Estevez, E., Petzold, T., Suter, C. M., Gregorevic, P., Kiens, B., Richter, E. A., James, D. E., Wojtaszewski, J. F. P., & Febbraio, M. A.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 27
- Issue
- 1
- Pages
- 237-251.e4
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2782804476
- Cited by
- 688
- References
- 29
- FWCI
- 18.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Whitham, M., Parker, B. L., Friedrichsen, M., Hingst, J. R., Hjorth, M., Hughes, W. E., Egan, C. L., Cron, L., Watt, K. I., Kuchel, R. P., Jayasooriah, N., Estevez, E., Petzold, T., Suter, C. M., Gregorevic, P., Kiens, B., Richter, E. A., James, D. E., Wojtaszewski, J. F. P., & Febbraio, M. A. (2018). Extracellular Vesicles Provide a Means for Tissue Crosstalk during Exercise. Cell Metabolism. https://doi.org/10.1016/j.cmet.2017.12.001
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
