SignalP 4.0: discriminating signal peptides from transmembrane regions
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The CCL11 A23T missense polymorphism lies directly at the signal peptide cleavage site of the eotaxin-1 precursor protein and is predicted to alter its cleavage in silico.
“This missense polymorphism lies directly at the signal peptide cleavage site of the eotaxin-1 precursor protein and is predicted to alter its cleavage in silico (Supplementary Figure 3).41”
From Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease (2015) · cites this paper as [41]
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- Authors
- Petersen, T. N., Brunak, S., von Heijne, G., & Nielsen, H.
- Affiliations
- Technical University of Denmark (DK)
- University of Copenhagen (DK)
- Corresponding author
- Nielsen, Henrik
- Venue
- Nature Methods
- Published
- 2011-09-29
- Volume
- 8
- Issue
- 10
- Pages
- 785-786
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2094201044
- Cited by
- 8,847
- References
- 16
- Citations by year
- 2026: 114 · 2025: 177 · 2024: 285 · 2023: 315 · 2022: 380 · 2021: 567 · 2020: 724 · 2019: 872 · 2018: 983 · 2017: 944 · 2016: 928 · 2015: 878 · 2014: 775 · 2013: 567 · 2012: 320
- FWCI
- 217.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Methods (publishedVersion)
- PubMed (publishedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Machine Learning in Bioinformatics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- signal peptide, transmembrane domain, protein secretion prediction, signal peptide prediction, membrane protein prediction
- MeSH terms
- Algorithms, Cell Membrane, Software, Computational Biology, Protein Sorting Signals
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