Viral Vectors for Studying Brain Mechanisms that Control Energy Homeostasis
Open accessAbstract
Viral vectors have been shown to be potent and versatile tools for genome editing. In the present Minireview, we focus on lentiviruses and adeno-associated viruses as vectors and their use in the study of the hypothalamic circuits involved in the regulation of energy homeostasis.
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The viral-Cre approach used here suffers from the inherent weakness that the SynI promoter-driven Cre will be expressed in all infected neurons, which might affect the role of specific neuronal populations.
“We acknowledge that the viral-Cre approach used here suffers from the inherent weakness that the SynI promoter-driven Cre will be expressed in all infected neurons, which might might the role of specific neuronal populations51.”
From IDOL regulates systemic energy balance through control of neuronal VLDLR expression (2019) · cites this paper as [51]
The supplied passage has no section or page label and contains only reference links, not discussion of the viral-Cre approach. Searches for SynI, promoter-driven Cre expression, and neuronal specificity found no substantive passage in our copy that addresses the claim. (LLM, conf=0.76)
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Foust, K. D., Wang, X., McGovern, V. L., Braun, L., Bevan, A. K., Haidet, A. M., Le, T. T., Morales, P. R., Rich, M. M., Burghes, A. H. M., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1610 · Cited by 688 · see citing works
RetractedSchwank, G., Koo, B.-K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C. K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.11.002 · Cited by 1,424 · see citing works
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989 · see citing works
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance
Schneeberger, M., Dietrich, M. O., Sebastián, D., Imbernón, M., Castaño, C., Garcia, A., Esteban, Y., Gonzalez-Franquesa, A., Rodríguez, I. C., Bortolozzi, A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.003 · Cited by 519 · see citing works
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IDOL regulates systemic energy balance through control of neuronal VLDLR expression
Lee, S. D., Priest, C., Bjursell, M., Gao, J., Arneson, D. V., Ahn, I. S., Diamante, G., van Veen, J. E., Massa, M. G., Calkin, A. C., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0127-7 · Cited by 26 · see citing works
- Authors
- Mancini, G., & Horvath, T. L.
- Affiliations
- Yale University (US)
- Corresponding author
- Mancini, Giacomo
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 27
- Issue
- 6
- Pages
- 1168-1175
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2806084969
- Cited by
- 10
- References
- 4
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1
- FWCI
- 0.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- viral vectors, lentivirus, adeno-associated virus, energy homeostasis, hypothalamus, hypothalamic circuits, genome editing, brain circuits
- MeSH terms
- Dependovirus, Animals, Energy Metabolism, Genetic Vectors, Homeostasis, Humans, Hypothalamus, Genetic Therapy, Lentivirus, Mice
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