Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741 · see citing works

A short amino acid sequence able to specify nuclear location

Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511 · see citing works

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355 · see citing works

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,927 · see citing works

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783 · see citing works

Generation and Analysis of Interleukin-4 Deficient Mice

Kühn, R., Rajewsky, K., & Müller, W. (1991) · Science · doi:10.1126/science.1948049 · Cited by 1,229 · see citing works

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

Sauer, B., & Henderson, N. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5166 · Cited by 1,213 · see citing works

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

Coffman, R. L., Ohara, J., Bond, M. W., Carty, J., Zlotnik, A., & Paul, W. E. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.12.4538 · Cited by 796 · see citing works

Bacteriophage P1 site-specific recombination

Sternberg, N. L., & Hamilton, D. L. (1981) · Journal of Molecular Biology · doi:10.1016/0022-2836(81)90375-2 · Cited by 791 · see citing works

Teratocarcinomas and embryonic stem cells: A practical approach

Krumlauf, R. K. (1987) · Trends in Genetics · doi:10.1016/0168-9525(87)90286-1 · Cited by 779 · see citing works

Targeted oncogene activation by site-specific recombination in transgenic mice.

Lakso, M., Sauer, B., Mosinger, B. J., Lee, E. J., Manning, R. W., Yu, S., Mulder, K. L., & Westphal, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6232 · Cited by 680 · see citing works

Tissue- and site-specific DNA recombination in transgenic mice.

Orban, P. C., Chui, D., & Marth, J. D. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6861 · Cited by 651 · see citing works

Development of the Primary Antibody Repertoire

Alt, F. W., Blackwell, T. K., & Yancopoulos, G. D. (1987) · Science · doi:10.1126/science.3317825 · Cited by 604 · see citing works

Functional expression of the cre-lox site-specific recombination system in the yeast Saccharomyces cerevisiae

Sauer, B. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.6.2087 · Cited by 482 · see citing works

Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

Neuberger, M. S. (1983) · The EMBO Journal · doi:10.1002/j.1460-2075.1983.tb01594.x · Cited by 455 · see citing works

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B‐CLL progenitor generation.

Gu, H., Förster, I., & Rajewsky, K. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07382.x · Cited by 392 · see citing works

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

Stavnezer, J., & Sirlin, S. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04182.x · Cited by 344 · see citing works

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

Jung, S., Rajewsky, K., & Radbruch, A. (1993) · Science · doi:10.1126/science.8438159 · Cited by 343 · see citing works

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

Hasty, P., Ramírez‐Solis, R., Krumlauf, R. K., & Bradley, A. (1991) · Nature · doi:10.1038/350243a0 · Cited by 331 · see citing works

Organization of the constant-region gene family of the mouse immunoglobulin heavy chain

Shimizu, A., Takahashi, N., Yaoita, Y., & Honjo, T. (1982) · Cell · doi:10.1016/0092-8674(82)90204-5 · Cited by 315 · see citing works

Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

Ehlich, A. (1993) · Cell · doi:10.1016/0092-8674(93)90398-a · Cited by 313 · see citing works

Organization of immunoglobulin heavy chain genes and allelic deletion model.

Honjo, T., & Kataoka, T. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.5.2140 · Cited by 293 · see citing works

Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes.

Stavnezer, J., Radcliffe, G. E., Lin, Y. C., Nietupski, J. B., Berggren, L., Sitia, R., & Gronowicz, E. S. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.20.7704 · Cited by 279 · see citing works

Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase.

Sauer, B., & Henderson, N. (1990) · PubMed · Cited by 259 · see citing works

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

Reaban, M. E., & Griffin, J. A. (1990) · Nature · doi:10.1038/348342a0 · Cited by 246 · see citing works

Circular DNA is excised by immunoglobulin class switch recombination

Iwasato, T., Shimizu, A., Honjo, T., & Yamagishi, H. (1990) · Cell · doi:10.1016/0092-8674(90)90248-d · Cited by 243 · see citing works

Switch circular DNA formed in cytokine-treated mouse splenocytes: Evidence for intramolecular DNA deletion in immunoglobulin class switching

Matsuoka, M., Yoshida, K., Maeda, T., Usuda, S., & Sakano, H. (1990) · Cell · doi:10.1016/0092-8674(90)90247-c · Cited by 242 · see citing works

Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses

Siekevitz, M., Kocks, C., Rajewsky, K., & Dildrop, R. (1987) · Cell · doi:10.1016/0092-8674(87)90073-0 · Cited by 222 · see citing works

Immunoglobulin Class Switching: Molecular and Cellular Analysis

Esser, C., & Radbruch, A. (1990) · Annual Review of Immunology · doi:10.1146/annurev.iy.08.040190.003441 · Cited by 221 · see citing works

Secondary genomic rearrangement events in pre‐B cells: VHDJH replacement by a LINE‐1 sequence and directed class switching.

Yancopoulos, G. D., DePinho, R. A., Zimmerman, K. A., Lutzker, S. G., Rosenberg, N. E., & Alt, F. W. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04637.x · Cited by 218 · see citing works

Genetic recombination

West, S. C. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90171-0 · Cited by 214 · see citing works

Circular DNA is a product of the immunoglobulin class switch rearrangement

von Schwedler, U., Jäck, H., & Wabl, M. R. (1990) · Nature · doi:10.1038/345452a0 · Cited by 209 · see citing works

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

Rothman, P. B., Lutzker, S. G., Cook, W. D., Coffman, R. L., & Alt, F. W. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.6.2385 · Cited by 206 · see citing works

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

Roth, D. B., Nakajima, P. B., Menetski, J. P., Bosma, M. J., & Gellert, M. F. (1992) · Cell · doi:10.1016/0092-8674(92)90117-u · Cited by 185 · see citing works

Testing an "in-out" targeting procedure for making subtle genomic modifications in mouse embryonic stem cells.

Valancius, V., & Smithies, O. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.3.1402 · Cited by 177 · see citing works

Production and analysis of chimeric mice

Bradley, A. (1987) · Cited by 174 · see citing works

Bacteriophage P1 cre gene and its regulatory region

Sternberg, N., Sauer, B., Hoess, R., & Abremski, K. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90228-7 · Cited by 171 · see citing works

CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication.

Hsieh, C. L., & Lieber, M. R. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05054.x · Cited by 167 · see citing works

The role of gene deletion in the immunoglobulin heavy chain switch

Rabbitts, T. H., Forster, A. M., Dunnick, W. A., & Bentley, D. L. (1980) · Nature · doi:10.1038/283351a0 · Cited by 163 · see citing works

Deletions in the constant region locus can account for switches in immunoglobulin heavy chain expression

Cory, S., Jackson, J. K., & Adams, J. M. (1980) · Nature · doi:10.1038/285450a0 · Cited by 103 · see citing works

Monoclonal anti‐allotype antibody towards BALB/c IgM Analysis of specificity and site of a V‐C crossover in recombinant strain BALB‐Igh‐Va/Igh‐Cb

Schüppel, R., Wilke, J., & Weiler, E. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170527 · Cited by 103 · see citing works

Molecular aspects of heavy-chain class switching.

Ca, G. (1989) · PubMed · Cited by 98 · see citing works

Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.

Radbruch, A., Müller, W., & Rajewsky, K. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.3954 · Cited by 97 · see citing works

Regulation of transcription of immunoglobulin germ‐line gamma 1 RNA: analysis of the promoter/enhancer.

Xu, M., & Stavnezer, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05037.x · Cited by 96 · see citing works

Directed Ig class switch recombination in activated murine B cells.

Winter, E., Krawinkel, U., & Radbruch, A. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02415.x · Cited by 92 · see citing works

Clonal analysis of B cells induced to secrete IgG by T cell-derived lymphokine(s).

Layton, J. E., Vitetta, E. S., Uhr, J. W., & Krammer, P. H. (1984) · The Journal of Experimental Medicine · doi:10.1084/jem.160.6.1850 · Cited by 87 · see citing works

Mouse Strain Identification

Festing, M. F. W. (1972) · Nature · doi:10.1038/238351a0 · Cited by 85 · see citing works

A monoclonal antibody against Igh6-4 determinant

Nishikawa, S., Sasaki, Y., Kina, T., Amagai, T., & Katsura, Y. (1986) · Immunogenetics · doi:10.1007/bf00377976 · Cited by 85 · see citing works

Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

Leung, H., & Maizels, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4154 · Cited by 72 · see citing works

Switch region content of hybridomas: the two spleen cell Igh loci tend to rearrange to the same isotype.

Hummel, M., Berry, J. K., & Dunnick, W. A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.10.3539 · Cited by 70 · see citing works

Complete nucleotide sequence of the murine gamma 3 switch region and analysis of switch recombination sites in two gamma 3-expressing hybridomas.

Szurek, P. F., Petrini, J. H. J., & Dunnick, W. A. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.1.620 · Cited by 64 · see citing works

Protective methylation of immunoglobulin and T cell receptor (TcR) gene loci prior to induction of class switch and TcR recombination

Burger, C., & Radbruch, A. (1990) · European Journal of Immunology · doi:10.1002/eji.1830201018 · Cited by 36 · see citing works

Constant-Region Genes of the Immunoglobulin Heavy Chain and the Molecular Mechanism of Class Switching

Honjo, T., Shimizu, A., & Yaoita, Y. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-354865-8.50012-1 · Cited by 36 · see citing works

Immunoglobulin Heavy Chain Switching in Cultured I.29 Murine B Lymphoma Cells: Commitment to an IgA or IgE Switch

Stavnezer, J., Abbott, J., & Sirlin, S. (1984) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-69860-6_21 · Cited by 26 · see citing works

Immunoglobulin gene expression and DNA methylation in murine pre‐B cell lines.

Akira, S., Sugiyama, H., Sakaguchi, N., & Kishimoto, T. (1984) · The EMBO Journal · doi:10.1002/j.1460-2075.1984.tb01866.x · Cited by 10 · see citing works

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475 · see citing works

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,494 · see citing works

Conditional gene targeting in macrophages and granulocytes using LysMcre mice

Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,143 · see citing works

Inducible Gene Targeting in Mice

Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,915 · see citing works

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15518 · Cited by 1,809 · see citing works

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Revy, P., Muto, T., Lévy, Y., Geissmann, F., Plebani, A., Sanal, Ö., Catalan, N., Forveille, M., Dufourcq-Lagelouse, R., Gennery, A. R., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00079-9 · Cited by 1,645 · see citing works

Evidence that fibroblasts derive from epithelium during tissue fibrosis

Iwano, M., Plieth, D., Danoff, T. M., Xue, C., Okada, H., & Neilson, E. G. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215518 · Cited by 1,589 · see citing works

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., & Rajewsky, K. (1994) · Science · doi:10.1126/science.8016642 · Cited by 1,397 · see citing works

β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin

Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352 · see citing works

Targeted expression of Cre recombinase to myelinating cells of the central nervous system in transgenic mice

Niwa‐Kawakita, M., Abramowski, V., Kalamarides, M., Thomas, G. D., & Giovannini, M. (2000) · genesis · doi:10.1002/(sici)1526-968x(200002)26:2 · Cited by 22 · see citing works

A<i>cre</i>-transgenic mouse strain for the ubiquitous deletion of<i>loxP</i>-flanked gene segments including deletion in germ cells

Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289 · see citing works

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage.

Lakso, M., Pichel, J. G., Gorman, J. R., Sauer, B., Okamoto, Y., Lee, E., Alt, F. W., & Westphal, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.5860 · Cited by 1,125 · see citing works

In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death

Lam, K., Kühn, R., & Rajewsky, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80373-6 · Cited by 1,101 · see citing works

DNA binding of the glucocorticoid receptor is not essential for survival

Reichardt, H. M., Kaestner, K. H., Tuckermann, J., Kretz, O., Wessely, O., Bock, R., Gass, P., Schmid, W., Herrlich, P., Angel, P., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81183-6 · Cited by 1,068 · see citing works

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978 · see citing works

Induction of medulloblastomas in <i>p53</i> -null mutant mice by somatic inactivation of <i>Rb</i> in the external granular layer cells of the cerebellum

Marino, S., Vooijs, M., van der Gulden, H., Jonkers, J., & Berns, A. (2000) · Genes &amp; Development · doi:10.1101/gad.14.8.994 · Cited by 920 · see citing works

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetesPreprint

Ahlgren, U., Jönsson, J., Jönsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918 · see citing works

Talking about a Revolution

Branda, C., & Dymecki, S. M. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00399-x · Cited by 863 · see citing works

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

Santo, J. P. D., Müller, W., Guy‐Grand, D., Fischer, A., & Rajewsky, K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.2.377 · Cited by 866 · see citing works

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis

Moerlooze, L. D., Spencer‐Dene, B., Revest, J., Hajihosseini, M. K., Rosewell, I. R., & Dickson, C. (2000) · Development · doi:10.1242/dev.127.3.483 · Cited by 863 · see citing works

Conditional control of gene expression in the mouse

Lewandoski, M. (2001) · Nature reviews genetics · doi:10.1038/35093537 · Cited by 442 · see citing works

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lübbert, H., & Bujard, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10933 · Cited by 780 · see citing works

Endothelin

Davenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011833 · Cited by 772 · see citing works

Inducible gene targeting in mice using the Cre/lox system.

Sauer, B. (1998) · Methods · doi:10.1006/meth.1998.0593 · Cited by 858 · see citing works

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

Taniuchi, I., Osato, M., Egawa, T., Sunshine, M. J., Bae, S., Komori, T., Ito, Y., & Littman, D. R. (2002) · Cell · doi:10.1016/s0092-8674(02)01111-x · Cited by 732 · see citing works

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

Monory, K., Massa, F., Egertová, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.006 · Cited by 706 · see citing works

Transgenic mice with hematopoietic and lymphoid specific expression of Cre

de Boer, J., Williams, A., Skavdis, G., Harker, N., Coles, M., Tolaini, M., Norton, T., Williams, K., Roderick, K., Potocnik, A. J., et al. (2003) · European Journal of Immunology · doi:10.1002/immu.200310005 · Cited by 739 · see citing works

B lymphocyte-specific, Cre-mediated mutagenesis in mice

Rickert, R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.6.1317 · Cited by 724 · see citing works

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

Zamanillo, D., Sprengel, R., Hvalby, Ø., Jensen, V., Burnashev, N., Rozov, A., Kaiser, K. M. M., Köster, H. J., Borchardt, T., Worley, P., et al. (1999) · Science · doi:10.1126/science.284.5421.1805 · Cited by 791 · see citing works

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

Olkhanud, P. B., Damdinsuren, B., Bodogai, M., Gress, R. E., Sen, R., Wejksza, K., Malchinkhuu, E., Wersto, R. P., & Biragyn, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4316 · Cited by 689 · see citing works

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

Srinivasan, L., Sasaki, Y., Calado, D. P., Zhang, B., Paik, J. H., DePinho, R. A., Kutok, J. L., Kearney, J. F., Otipoby, K. L., & Rajewsky, K. (2009) · Cell · doi:10.1016/j.cell.2009.08.041 · Cited by 663 · see citing works

hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo

Zhuo, L., Theis, M., Álvarez-Maya, I., Brenner, M., Willecke, K., & Messing, A. (2001) · genesis · doi:10.1002/gene.10008 · Cited by 660 · see citing works

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation

Long, F., Zhang, X. M., Karp, S. J., Yang, Y., & McMahon, A. P. (2001) · Development · doi:10.1242/dev.128.24.5099 · Cited by 654 · see citing works

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

Chaudhuri, J., & Alt, F. W. (2004) · Nature reviews. Immunology · doi:10.1038/nri1395 · Cited by 623 · see citing works

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

Stetson, D. B., Mohrs, M., Reinhardt, R. L., Baron, J. L., Wang, Z., Gapin, L., Kronenberg, M., & Locksley, R. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030630 · Cited by 618 · see citing works

Correction: Stat3 Activation Is Responsible for IL-6–Dependent T Cell Proliferation through Preventing Apoptosis: Generation and Characterization of T Cell–Specific Stat3-Deficient Mice

Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500168 · Cited by 616 · see citing works

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

Su, I.-H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., & Tarakhovsky, A. (2002) · Nature Immunology · doi:10.1038/ni876 · Cited by 614 · see citing works

Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development

Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S., Matsuo, I., & Furukawa, T. (2003) · Nature Neuroscience · doi:10.1038/nn1155 · Cited by 607 · see citing works

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

Kanegae, Y., Lee, G., Sato, Y., Tanaka, M., Nakal, M., Sakaki, T., Sugano, S., & Saito, I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.19.3816 · Cited by 606 · see citing works

Dosage requirement of Pitx2 for development of multiple organs

Gage, P. J., Suh, H., & Camper, S. A. (1999) · Development · doi:10.1242/dev.126.20.4643 · Cited by 600 · see citing works

Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation

Honjo, T., Kinoshita, K., & Muramatsu, M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.090501.112049 · Cited by 598 · see citing works

Early-Onset Epilepsy and Postnatal Lethality Associated with an Editing-Deficient GluR-B Allele in Mice

Brusa, R., Zimmermann, F., Koh, D., Feldmeyer, D., Gass, P., Seeburg, P. H., & Sprengel, R. (1995) · Science · doi:10.1126/science.270.5242.1677 · Cited by 594 · see citing works

Cytokine Regulation and Function in T Cells

Dong, C. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053702 · Cited by 594 · see citing works

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells

Loonstra, A., Vooijs, M., Beverloo, H. B., Allak, B. A., van Drunen, E., Kanaar, R., Berns, A. J. M., & Jonkers, J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161269798 · Cited by 591 · see citing works

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

Suzuki, A., Tsukio, M., Ohteki, T., Sasaki, T., Kaisho, T., Kimura, Y., Yoshida, R., Wakeham, A. C., Higuchi, T., Fukumoto, M., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00134-0 · Cited by 589 · see citing works

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4652 · Cited by 584 · see citing works

Survival of Resting Mature B Lymphocytes Depends on BCR Signaling via the Igα/β Heterodimer

Kraus, M., Alimzhanov, M. B., Rajewsky, N., & Rajewsky, K. (2004) · Cell · doi:10.1016/j.cell.2004.05.014 · Cited by 573 · see citing works

Functional analysis of Sox8 and Sox9 during sex determination in the mouse

Chaboissier, M.-C., Kobayashi, A., Vidal, V., Lützkendorf, S., van de Kant, H. V. D., Wegner, M., de Rooij, D., Behringer, R., & Schedl, A. (2004) · Development · doi:10.1242/dev.01087 · Cited by 568 · see citing works

β1-Class Integrins Regulate the Development of Laminae and Folia in the Cerebral and Cerebellar Cortex

Graus-Porta, D., Blaess, S., Senften, M., Littlewood-Evans, A., Damsky, C. H., Huang, Z., Orban, P. C., Klein, R., Schittny, J. C., & Müller, U. (2001) · Neuron · doi:10.1016/s0896-6273(01)00374-9 · Cited by 559 · see citing works

Disruption of Semaphorin III/D Gene Causes Severe Abnormality in Peripheral Nerve Projection

Taniguchi, M., Yuasa, S., Fujisawa, H., Naruse, I., Saga, S., Mishina, M., & Yagi, T. (1997) · Neuron · doi:10.1016/s0896-6273(00)80368-2 · Cited by 516 · see citing works

Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation

Fehling, H. J., Lacaud, G., Kubo, A., Kennedy, M., Robertson, S. M., Keller, G. M., & Kouskoff, V. (2003) · Development · doi:10.1242/dev.00589 · Cited by 500 · see citing works

A Transgenic Mouse Line That Retains Cre Recombinase Activity in Mature Oocytes Irrespective of thecreTransgene Transmission

Sakai, K., & Miyazaki, J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7111 · Cited by 494 · see citing works

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain

Hayashi, S., Lewis, P. M., Pevny, L., & McMahon, A. P. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(03)00099-6 · Cited by 492 · see citing works

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Williams, M. R., Arthur, J. S. C., Balendran, A., KAAY, J. V. D., Poli, V., Cohen, P., & Alessi, D. R. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00441-3 · Cited by 471 · see citing works

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

Kwon, C.-H., Zhu, X., Zhang, J., Knoop, L. L., Tharp, R., Smeyne, R. J., Eberhart, C. G., Burger, P. C., & Baker, S. J. (2001) · Nature Genetics · doi:10.1038/ng781 · Cited by 478 · see citing works

Conditional gene targeting.

Rajewsky, K., Gu, H., Kühn, R., Betz, U. A. K., Müller, W., Roes, J., & Schwenk, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118828 · Cited by 461 · see citing works

Analysis of Type 2 Immunity In Vivo with a Bicistronic IL-4 Reporter

Mohrs, M., Shinkai, K., Mohrs, K., & Locksley, R. M. (2001) · Immunity · doi:10.1016/s1074-7613(01)00186-8 · Cited by 460 · see citing works

Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines

Doble, B. W., Patel, S., Wood, G. A., Kockeritz, L. K., & Woodgett, J. R. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.001 · Cited by 449 · see citing works

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

Ramiro, A. R., Stavropoulos, P., Janković, M., & Nussenzweig, M. C. (2003) · Nature Immunology · doi:10.1038/ni920 · Cited by 437 · see citing works

Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells

O’Gorman, S., Dagenais, N., Qian, M., & Marchuk, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14602 · Cited by 436 · see citing works

TGF-β Receptor Controls B Cell Responsiveness and Induction of IgA In Vivo

Cazac, B. B., & Roes, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)00044-3 · Cited by 430 · see citing works

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

Molnarfi, N., Schulze‐Topphoff, U., Weber, M. S., Patarroyo, J. C., Prod’homme, T., Varrin‐Doyer, M., Shetty, A., Linington, C., Slavin, A., Hidalgo, J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130699 · Cited by 422 · see citing works

Altered T cell development in mice with a targeted mutation of the CD3‐epsilon gene.

Malissen, M., Gillet, A., Ardouin, L., Bouvier, G., Trucy, J., Ferrier, P., Vivier, É., & MALISSEN, B. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00146.x · Cited by 405 · see citing works

Improved properties of FLP recombinase evolved by cycling mutagenesis

Buchholz, F., Angrand, P., & Stewart, A. F. (1998) · Nature Biotechnology · doi:10.1038/nbt0798-657 · Cited by 404 · see citing works

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

Rolink, A. G., Melchers, F., & Andersson, J. (1996) · Immunity · doi:10.1016/s1074-7613(00)80258-7 · Cited by 404 · see citing works

Analysis of C-MYC Function in Normal Cells via Conditional Gene-Targeted Mutation

de Alborán, I. M., O’Hagan, R. C., Gärtner, F., Malynn, B. A., Davidson, L., Rickert, R. C., Rajewsky, K., DePinho, R. A., & Alt, F. W. (2001) · Immunity · doi:10.1016/s1074-7613(01)00088-7 · Cited by 398 · see citing works

Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase

Lallemand, Y., Luria, V. A., Haffner‐Krausz, R., & Lonai, P. (1998) · Transgenic Research · doi:10.1023/a:1008868325009 · Cited by 393 · see citing works

Mechanism and control of class-switch recombination

Manis, J. P., Tian, M., & Alt, F. W. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(01)02111-1 · Cited by 386 · see citing works

Impaired Immunity and Enhanced Resistance to Endotoxin in the Absence of Neutrophil Elastase and Cathepsin G

Tkalcevic, J., Novelli, M. R., Phylactides, M., Iredale, J. P., Segal, A. W., & Roes, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)80173-9 · Cited by 379 · see citing works

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T., & Nakayama, K. I. (2016) · Nature · doi:10.1038/nature19357 · Cited by 353 · see citing works

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

Alimzhanov, M. B., Kuprash, D. V., Kosco‐Vilbois, M. H., Luz, A., Turetskaya, R. L., Tarakhovsky, A., Rajewsky, K., Nedospasov, S. A., & Pfeffer, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.17.9302 · Cited by 370 · see citing works

Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2Preprint

Giovannini, M., Robanus-Maandag, E. C., van der Valk, M., Niwa‐Kawakita, M., Abramowski, V., Goutebroze, L., Woodruff, J. M., Berns, A. J. M., & Thomas, G. D. (2000) · Genes & Development · doi:10.1101/gad.14.13.1617 · Cited by 369 · see citing works

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

Trimboli, A. J., Fukino, K., de Bruin, A., Guo, W., Shen, L., Tanner, S. M., Creasap, N., Rosol, T. J., Robinson, M. L., Eng, C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2148 · Cited by 365 · see citing works

Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRβ-deficient mice

Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., & Gustafsson, J.-Α. (2001) · Journal of Clinical Investigation · doi:10.1172/jci9794 · Cited by 364 · see citing works

Generation of a germ cell‐specific mouse transgenic Cre line, Vasa‐Cre

Gallardo, T. D., Shirley, L. J., John, G. B., & Castrillón, D. H. (2007) · genesis · doi:10.1002/dvg.20310 · Cited by 366 · see citing works

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice.

Dymecki, S. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.12.6191 · Cited by 361 · see citing works

Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN

Bon, A. L., Thompson, C., Kamphuis, E., Durand, V., Rossmann, C., Kalinke, U., & Tough, D. F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2074 · Cited by 361 · see citing works

Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice

Harrison, K. A., Thaler, J. P., Pfaff, S. L., Gu, H., & Kehrl, J. H. (1999) · Nature Genetics · doi:10.1038/12674 · Cited by 358 · see citing works

Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1β

Coffinier, C., Gresh, L., Fiette, L., Tronche, F., Schütz, G., Babinet, C., Pontoglio, M., Yaniv, M., & Barra, J. (2002) · Development · doi:10.1242/dev.129.8.1829 · Cited by 354 · see citing works

Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission

Yılmaz, B., Portugal, S., Tran, T. M., Gozzelino, R., Ramos, S., Gomes, J., Regalado, A. P., Cowan, P. J., d’Apice, A. J. F., Chong, A. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.053 · Cited by 352 · see citing works

A highly efficient ligand‐regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

Vooijs, M., Jonkers, J., & Berns, A. J. M. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve064 · Cited by 354 · see citing works

Site-specific recombinases: tools for genome engineering

Kilby, N. J., Snaith, M. R., & Murray, J. A. H. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90104-p · Cited by 349 · see citing works

Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes

Kim, H., Kim, M., Im, S.-K., & Fang, S. (2018) · Laboratory Animal Research · doi:10.5625/lar.2018.34.4.147 · Cited by 283 · see citing works

Gene Therapy: Promises and Problems

Pfeifer, A., & Verma, I. M. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.177 · Cited by 344 · see citing works

Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development

Metzler, M., Gertz, A., Sarkar, M., Schachter, H., Schrader, J. W., & Marth, J. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06480.x · Cited by 339 · see citing works

Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of Autoimmunity

Stranges, P. B., Watson, J., Cooper, C. J., Choisy-Rossi, C.-M., Stonebraker, A. C., Beighton, R. A., Hartig, H. M., Sundberg, J. P., Servick, S. V., Kaufmann, G. F., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.016 · Cited by 331 · see citing works

Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids

Schmidt, E. E., Taylor, D., Prigge, J. R., Barnett, S., & Capecchi, M. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240471297 · Cited by 335 · see citing works

In vivo functional analysis of the Hoxa-1 3′ retinoic acid response element (3′ RARE)

Dupé, V., Davenne, M., Brocard, J., Dollé, P., Mark, M. P., Dierich, A., Chambon, P., & Rijli, F. M. (1997) · Development · doi:10.1242/dev.124.2.399 · Cited by 335 · see citing works

Mice lacking all conventional MHC class II genes

Madsen, L. S., Labrecque, N., Engberg, J., Dierich, A., Svejgaard, A., Benoist, C. O., Mathis, D. J., & Fugger, L. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10338 · Cited by 331 · see citing works

Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination

Lee, G., & Saito, I. (1998) · Gene · doi:10.1016/s0378-1119(98)00325-4 · Cited by 326 · see citing works

Perinucleolar Targeting of the Inactive X during S Phase: Evidence for a Role in the Maintenance of Silencing

Zhang, L., Huynh, K. D., & Lee, J. T. (2007) · Cell · doi:10.1016/j.cell.2007.03.036 · Cited by 322 · see citing works

Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences

Dudley, D. D., Chaudhuri, J., Bassing, C. H., & Alt, F. W. (2005) · Advances in immunology · doi:10.1016/s0065-2776(04)86002-4 · Cited by 315 · see citing works

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

Xiao, Y. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.2985 · Cited by 316 · see citing works

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

Mountford, P. S., Zevnik, B., Düwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I., & Smith, A. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4303 · Cited by 312 · see citing works

Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity during Salmonella typhimurium Infection

Neves, P., Lampropoulou, V., Calderón‐Gómez, E., Roch, T., Stervbo, U., Shen, P., Kühl, A. A., Loddenkemper, C., Haury, M., Nedospasov, S. A., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.016 · Cited by 307 · see citing works

Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5

Stanley, E. G., Biben, C., Elefanty, A. G., Barnett, L. D., Köentgen, F., Robb, L., & Harvey, R. P. (2002) · The International Journal of Developmental Biology · doi:10.1387/ijdb.12141429 · Cited by 306 · see citing works

Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

Saijo, K., Schmedt, C., Su, I.-H., Karasuyama, H., Lowell, C. A., Reth, M. G., Adachi, T., Patke, A., Santana, A., & Tarakhovsky, A. (2003) · Nature Immunology · doi:10.1038/ni893 · Cited by 307 · see citing works

Dre recombinase, like Cre, is a highly efficient site-specific recombinase in E. coli , mammalian cells and mice

Anastassiadis, K., Fu, J., Patsch, C., Hu, S., Weidlich, S., Duerschke, K., Buchholz, F., Edenhofer, F., & Stewart, A. F. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.003087 · Cited by 303 · see citing works

Mouse models of metastasis: progress and prospects

Gómez-Cuadrado, L., Tracey, N., Ma, R., Qian, B., & Brunton, V. G. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030403 · Cited by 298 · see citing works

Mouse models for human lung cancerPreprint

Meuwissen, R. L. J., & Berns, A. J. M. (2005) · Genes & Development · doi:10.1101/gad.1284505 · Cited by 301 · see citing works

Pillars Article: Independent Control of Immunoglobulin Switch Recombination at Individual Switch Regions Evidenced through Cre-loxP-Mediated Gene Targeting. Cell. 1993. 73: 1155-1164

Gu, H., Zou, Y.-R., & Rajewsky, K. (2013) · The Journal of Immunology · doi:10.1093/jimmunol/191.1.7 · Cited by 3 · see citing works

IgH joining region plus intronic enhancer

Mak, T. W., Penninger, J. M., Roder, J., Rossant, J., & Saunders, M. E. (1998) · Elsevier eBooks · doi:10.1016/b978-012466044-1/50318-5

Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequences.

Leung, H., & Maizels, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.9.4154 · Cited by 72 · see citing works

Shutdown of Class Switch Recombination by Deletion of a Switch Region Control Element

Jung, S., Rajewsky, K., & Radbruch, A. (1993) · Science · doi:10.1126/science.8438159 · Cited by 343 · see citing works

Regulation of Switch Recombination to the Murine γ 1 Gene

Dunnick, W. A., Elenich, L. A., Berry, J., Albrecht, D. W., Stavnezer, J., & Claflin, J. L. (1992) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-77633-5_17 · Cited by 4 · see citing works