The DOI matches its Crossref record; 165 of the 165 references it cites were found in a registry or an index.
The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases
Open accessAbstract
MIC-1/GDF15 is a stress response cytokine and a distant member of the transforming growth factor beta (TGFb) superfamily, with no close relatives. It acts via a recently identified receptor called glial-derived neurotrophic factor (GDNF) receptor alpha-like (GFRAL), which is a distant orphan member of the GDNF receptor family that signals through the tyrosine kinase receptor Ret. MIC-1/GDF15 expression and serum levels rise in response to many stimuli that initiate cell stress and as part of a wide variety of disease processes, most prominently cancer and cardiovascular disease. The best documented actions of MIC-1/GDF15 are on regulation of energy homeostasis. When MIC-1/GDF15 serum levels are substantially elevated in diseases like cancer, it subverts a physiological pathway of appetite regulation to induce an anorexia/cachexia syndrome initiated by its actions on hindbrain neurons. These effects make it a potential target for the treatment of both obesity and anorexia/cachexia syndromes, disorders lacking any highly effective, readily accessible therapies.
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MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily
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Self-citationA mitochondrial specific stress response in mammalian cells
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GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
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The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
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GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
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GDF15 mediates the effects of metformin on body weight and energy balance
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GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
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Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
Wischhusen, J., Melero, I., & Fridman, W. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00951 · Cited by 506
Area postrema cell types that mediate nausea-associated behaviors
Zhang, C., Kaye, J. A., Cai, Z., Wang, Y., Prescott, S. L., & Liberles, S. D. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.010 · Cited by 263
Metadata
- Authors
- Tsai, V. W. W., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 28
- Issue
- 3
- Pages
- 353-368
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2891822635
- Cited by
- 409
- References
- 165
- FWCI
- 26.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tsai, V. W. W., Husaini, Y., Sainsbury, A., Brown, D. A., & Breit, S. N. (2018). The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases. Cell Metabolism. https://doi.org/10.1016/j.cmet.2018.07.018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
