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Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients

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Comparison of 13C MRI of hyperpolarized [1‐13C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model

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Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

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Quo Vadis Hyperpolarized 13C MRI?

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Lactate signaling and immune suppression in tumors: mechanisms and therapeutic implications

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PDGF-BB accelerates TSCC via fibroblast lactates limiting miR-26a-5p and boosting mitophagy

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Metabolic imaging across scales reveals distinct prostate cancer phenotypes

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Integrative metabolic flux analysis reveals an indispensable dimension of phenotypes

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Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance

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Hyperpolarized Carbon-13 MRI in Breast Cancer

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Biopolymer and Biomaterial Conjugated Iron Oxide Nanomaterials as Prostate Cancer Theranostic Agents: A Comprehensive Review

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Imaging immunomodulatory treatment responses in a multiple sclerosis mouse model using hyperpolarized 13C metabolic MRI

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Kinetic analysis of multi‐resolution hyperpolarized 13C human brain MRI to study cerebral metabolism

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Characterizing Metabolic Heterogeneity of Hepatocellular Carcinoma with Hyperpolarized 13 C Pyruvate MRI and Mass Spectrometry

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Non-Invasive Differentiation of M1 and M2 Activation in Macrophages Using Hyperpolarized 13C MRS of Pyruvate and DHA at 1.47 Tesla

Qiao, K., Page, L. M. L., & Chaumeil, M. M. (2021) · Metabolites · doi:10.3390/metabo11070410 · Cited by 11

Key considerations for a prostate cancer mRNA vaccine

Lin, G., Elkashif, A., Saha, C., Coulter, J. A., Dunne, N., & McCarthy, H. O. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104643 · Cited by 10

Prospective clinical sequencing of 1016 Chinese prostate cancer patients: uncovering genomic characterization and race disparity

Yu, W., Zhang, T., Wang, B., Pan, J. G., Jin, S., Fang, B., Gu, W., Qin, X., Dai, B., Lin, G., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13511 · Cited by 9

Improving multiparametric MR ‐ transrectal ultrasound guided fusion prostate biopsies with hyperpolarized 13 C pyruvate metabolic imaging: A technical development study

Chen, H., Bok, R., Cooperberg, M. R., Nguyen, H. G., Shinohara, K., Westphalen, A. C., Wang, Z. J., Ohliger, M. A., Gebrezgiabhier, D., Carvajal, L. E., et al. (2022) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29399 · Cited by 9

Combined 23Na and 13C imaging at 3.0 Tesla using a single‐tuned large FOV birdcage coil

Kaggie, J. D., Lanz, T. E., McLean, M. A., Riemer, F., Schulte, R. F., Benjamin, A. J. V., Kessler, D. A., Sun, C. J., Gilbert, F. J., Graves, M. J., et al. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28772 · Cited by 9

Prostate cancer research in the 21st century; report from the 2021 Coffey‐Holden prostate cancer academy meeting

Miyahira, A. K., Zarif, J. C., Coombs, C. C., Flavell, R. R., Russo, J. W., Zaidi, S., Zhao, D., Zhao, S. G., Pienta, K. J., & Soule, H. R. (2021) · The Prostate · doi:10.1002/pros.24262 · Cited by 8

Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes

Dudka, I., Lundquist, K., Wikström, P., Bergh, A. R. J., & Gröbner, G. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04747-7 · Cited by 8

Metabolic Profiling to Assess Response to Targeted and Immune Therapy in Melanoma

Farah, C., Mignion, L., & Jordan, B. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031725 · Cited by 8

Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer

de Kouchkovsky, I., Nguyen, H. G., Chen, H., Liu, X., Qin, H., Stohr, B. A., Santos, R. D., Ohliger, M. A., Wang, Z. J., Bok, R., et al. (2024) · Journal of Magnetic Resonance Open · doi:10.1016/j.jmro.2024.100165 · Cited by 8

The potential of hyperpolarised 13C-MRI to target glycolytic tumour core in prostate cancer

Sushentsev, N., McLean, M. A., Warren, A. Y., Brodie, C. R., Jones, J. L., Gallagher, F. A., & Barrett, T. (2022) · European Radiology · doi:10.1007/s00330-022-08929-7 · Cited by 7

Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer

Perkons, N. R., Johnson, O., Pilla, G., Profka, E., Mercadante, M., Ackerman, D., & Gade, T. P. F. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0826 · Cited by 7

Cardiac pH-Imaging With Hyperpolarized MRI

Bøgh, N., Hansen, E. S. S., Mariager, C. Ø., Bertelsen, L. B., Ringgaard, S., & Laustsen, C. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.603674 · Cited by 7

Metabolic traits ruling the specificity of the immune response in different cancer types

Flerin, N. C., Cappellesso, F., Pretto, S., & Mazzone, M. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.10.011 · Cited by 7

Emerging role of multiparametric magnetic resonance imaging in identifying clinically relevant localized prostate cancer

Williams, C., Daneshvar, M., & Pinto, P. A. (2021) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000717 · Cited by 7

Characterization of Distinctive In Vivo Metabolism between Enhancing and Non-Enhancing Gliomas Using Hyperpolarized Carbon-13 MRI

Park, S., Hashizume, R., Kim, S. K., & Park, I. (2021) · Metabolites · doi:10.3390/metabo11080504 · Cited by 7

Hyperpolarized 13C tracers: Technical advancements and perspectives for clinical applications

Fiedorowicz, M., Wieteska, M., Rylewicz, K., Kossowski, B., Piątkowska-Janko, E., Czarnecka, A. M., Toczyłowska, B., & Bogorodzki, P. (2021) · Journal of Applied Biomedicine · doi:10.1016/j.bbe.2021.03.010 · Cited by 7

Targeting carbonic anhydrase IX / XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Pardella, E., Comito, G., Ippolito, L., Pranzini, E., Iozzo, M., Gangarossa, G., Virgilio, F. D., Bua, S., Nocentini, A., Sandrini, G., et al. (2025) · Molecular Oncology · doi:10.1002/1878-0261.70083 · Cited by 6

Icariin-curcumol inhibits histone H3K18 lactylation and FOXM1 expression to enhance the sensitivity of prostate cancer cells to docetaxel

Sheng, W., Li, Y., Tan, T., Yu, X., Huang, X., Li, L., Zhang, C., Chen, Y., Liu, L., Feng, M., et al. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03927-3 · Cited by 6

Mutual-information based optimal experimental design for hyperpolarized $$^{13}$$C-pyruvate MRI

Jha, P. K., Walker, C. J., Mitchell, D., Oden, J. T., Schellingerhout, D., Bankson, J. A., & Fuentes, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-44958-y · Cited by 5

A reproducible dynamic phantom for sequence testing in hyperpolarised 13C-magnetic resonance

Chowdhury, R., Papoutsaki, M., Müller, C. A., Smith, L. A., Gong, F., Bullock, M., Rogers, H. J., Mathew, M., Syer, T., Singh, S., et al. (2022) · British Journal of Radiology · doi:10.1259/bjr.20210770 · Cited by 5

Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples

Lee, G., Ruan, T., Wong, C., Deh, K., Abolarin, A., Correa, A., Keshari, K. R., & Jeong, S. (2022) · Bioengineering · doi:10.3390/bioengineering10010014 · Cited by 5

Dynamic volumetric hyperpolarized 13C imaging with multi‐echo EPI

Deh, K., Granlund, K. L., Eskandari, R., Kim, N., Mamakhanyan, A., & Keshari, K. R. (2020) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28466 · Cited by 5

Moving from conventional to adaptive risk stratification for oropharyngeal cancer

Sandulache, V. C., Kirby, R. P., & Lai, S. Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1287010 · Cited by 4

Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes

Chen, H., de Kouchkovsky, I., Bok, R., Ohliger, M. A., Wang, Z. J., Gebrezgiabhier, D., Nickles, T. M., Carvajal, L. E., Gordon, J. W., Larson, P. E. Z., et al. (2025) · Cancers · doi:10.3390/cancers17132211 · Cited by 4

Initial Experience of Metabolic Imaging With Hyperpolarized [1‐ 13C ]pyruvate MRI in Kidney Transplant Patients

Liu, X., Lai, Y., Cui, D., Kung, S., Park, M., Laszik, Z. G., Larson, P. E. Z., & Wang, Z. J. (2024) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29580 · Cited by 4

In vivo hyperpolarized carbon-13 diffusion weighted MRI measures lactate metabolism and transport in prostate cancer

Qin, H. (2015) · eScholarship (California Digital Library)

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures

Sriram, R., Criekinge, M. V., Santos, J. D., Ahamed, F., Qin, H., Nolley, R., Santos, R. D., Tabatabai, Z. L., Bok, R., Keshari, K. R., et al. (2020) · Cancers · doi:10.3390/cancers12030537 · Cited by 26

Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study

Chen, H., Aggarwal, R. R., Bok, R., Ohliger, M. A., Zhu, Z., Lee, P., Gordon, J. W., Criekinge, M. V., Carvajal, L. E., Slater, J. B., et al. (2019) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-019-0180-z · Cited by 105

Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading

Albers, M. J., Bok, R., Chen, A. P., Cunningham, C. H., Zierhut, M. L., Zhang, V. Y., Kohler, S. J., Tropp, J. S., Hurd, R. E., Yen, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0749 · Cited by 521

Abstract 4106: Hyperpolarized [1-13C]-pyruvate/lactate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts response to lactate dehydrogenase inhibition

Scroggins, B. T., Matsuo, M., White, A. O., Saito, K., Munasinghe, J., Sourbier, C., Yamamoto, K., Diaz, V., Mitchell, J. B., Krishna, M. C., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4106