The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1
Open accessAbstract
Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of primary prostate cancer. We show that the time to max of pyruvate does not vary significantly within patients undergoing two separate injections or across patients. Furthermore, we show that lactate increases with Gleason grade. RNA sequencing data demonstrate a significant increase in the predominant pyruvate uptake transporter, monocarboxylate transporter 1. Increased protein expression was also observed in regions of high lactate signal, implicating it as the driver of lactate signal in vivo. Targeted DNA sequencing for actionable mutations revealed the highest lactate occurred in patients with PTEN loss. This work identifies a potential link between actionable genomic alterations and metabolic information derived from hyperpolarized pyruvate MRI.
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“In human prostate cancer, tumor grade correlates with MCT1 expression and with imaging of 13C-lactate after injection of hyperpolarized 13C-pyruvate (122).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [122]
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voom: precision weights unlock linear model analysis tools for RNA-seq read counts
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Regulation of cancer cell metabolism
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Integrative Genomic Profiling of Human Prostate Cancer
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Self-citationThe Molecular Taxonomy of Primary Prostate Cancer
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Glucose feeds the TCA cycle via circulating lactate
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Metabolic reprogramming and cancer progression
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Metadata
- Authors
- Granlund, K. L., Tee, S.-S., Vargas, H. A., Lyashchenko, S. K., Reznik, E., Fine, S., Laudone, V., Eastham, J. A., Touijer, K. A., Reuter, V. E., Gonen, M., Sosa, R. E., Nicholson, D., Guo, Y. W., Chen, A. P., Tropp, J., Robb, F., Hricak, H., & Keshari, K. R.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Keshari, Kayvan R.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 31
- Issue
- 1
- Pages
- 105-114.e3
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC6949382
- OpenAlex
- W2975630107
- Cited by
- 138
- References
- 57
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 21 · 2023: 25 · 2022: 19 · 2021: 32 · 2020: 18
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- hyperpolarized MRI, prostate cancer, pyruvate metabolism, lactate, MCT1, Gleason grade, tumor metabolic imaging, PTEN loss, actionable mutations, tumor grade
- MeSH terms
- RNA-Seq, Monocarboxylate Transport Protein 1, Aged, Carbon Isotopes, Humans, Kinetics, Magnetic Resonance Imaging, Male, Middle Aged, Prostatic Neoplasms, Reproducibility of Results, Pyruvic Acid, Lactic Acid, Monocarboxylic Acid Transporters, Symporters, PTEN Phosphohydrolase, Neoplasm Grading
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