Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154

Methods in Mammalian Autophagy Research

Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497

mixOmics: An R package for ‘omics feature selection and multiple data integration

Rohart, F., Gautier, B., Singh, A., & Lê Cao, K.-A. (2017) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1005752 · Cited by 4,056

Autophagy: cellular and molecular mechanisms

Glick, D. R., Barth, S., & Macleod, K. F. (2010) · The Journal of Pathology · doi:10.1002/path.2697 · Cited by 3,995

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 9×

The paradox of aging: Aging-related shifts in T cell function and metabolism

Quinn, K. M., Moreno-Vicencio, D., & Gruta, N. L. L. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101834 · Cited by 28

The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury

Liu, C.-J., Wang, L., & Tsai, F. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47030176 · Cited by 30

Osteoimmunology and aging: Mechanisms, implications, and therapeutic perspectives

Wang, Y.-T., Zheng, S.-Y., Luo, Y., Xiao, W., Huang, C., & Li, Y. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102822 · Cited by 35

CD4+ T Cells at the Center of Inflammaging

Kroemer, G., & Zitvogel, L. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.016 · Cited by 31

Considering Cause and Effect of Immune Cell Aging on Cardiac Repair after Myocardial Infarction

Tobin, S. W., Alibhai, F. J., Weisel, R. D., & Li, R. (2020) · Cells · doi:10.3390/cells9081894 · Cited by 30

Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence

Martin, D. E., Torrance, B. L., Haynes, L., & Bartley, J. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714742 · Cited by 29

Association between systemic immune-inflammation index and insulin resistance and mortality

Deng, X., Liu, D., Li, M., He, J., & Fu, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-51878-y · Cited by 28

Astragaloside IV enhances autophagy to suppress endoplasmic reticulum stress and pyroptosis after spinal cord injury

Jiang, Z., Wu, Z., Jin, Y., Xu, K., Shu, W., Wu, Y., Ying, J., Wu, J., Geng, Y., Hong, C., et al. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112571 · Cited by 28

Aging, Osteo-Sarcopenia, and Musculoskeletal Mechano-Transduction

Leser, J. M., Harriot, A. D., Buck, H., Ward, C. W., & Stains, J. P. (2021) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2021.782848 · Cited by 29

Improving intestinal inflammaging to delay aging? A new perspective

Zhang, L., Yan, J., Zhang, C., Feng, S., Zhan, Z., Bao, Y., Zhan, Z., & Chao, G. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111841 · Cited by 27

Defective autophagy and autophagy activators in myasthenia gravis: a rare entity and unusual scenario

Al-Kuraishy, H. M., Sulaiman, G. M., Jabir, M. S., Mohammed, H. A., Al-Gareeb, A. I., Albukhaty, S., Klionsky, D. J., & Abomughaid, M. M. (2024) · Autophagy · doi:10.1080/15548627.2024.2315893 · Cited by 27

Nobiletin Ameliorates Aging of Chicken Ovarian Prehierarchical Follicles by Suppressing Oxidative Stress and Promoting Autophagy

Bai, J., Wang, X., Chen, Y., Yuan, Q., Yang, Z., Mi, Y., & Zhang, C. (2024) · Cells · doi:10.3390/cells13050415 · Cited by 27

Aging reshapes the adaptive immune system from healer to saboteur

Delgado-Pulido, S., Yousefzadeh, M. J., & Mittelbrunn, M. (2025) · Nature Aging · doi:10.1038/s43587-025-00906-1 · Cited by 29

Is early life adversity a trigger towards inflammageing?

Merz, M. P., & Turner, J. D. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111377 · Cited by 29

CLEC16A—An Emerging Master Regulator of Autoimmunity and Neurodegeneration

Pandey, R., Bakay, M. A., & Hakonarson, H. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098224 · Cited by 30

Targeting mitochondria for ovarian aging: new insights into mechanisms and therapeutic potential

Wang, Z., Wang, Z.-J., Liu, H.-C., Wang, C.-Y., Wang, Y., Yang, Y., Zhao, C., Wang, G., & Wan, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1417007 · Cited by 27

Mitophagy and Ferroptosis in Sepsis-Induced ALI/ARDS: Molecular Mechanisms, Interactions and Therapeutic Prospects of Medicinal Plants

Cheng, H., Wang, X., Yao, J., Yang, C., & Liu, J. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s488655 · Cited by 29

Natural Modulators of Key Signaling Pathways in Skin Inflammageing

Ren, Q., Qu, L., Yuan, Y., & Wang, F. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s502252 · Cited by 29

Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV

Zhang, Z., Tan, R., Xiong, Z., Feng, Y., & Chen, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1562845 · Cited by 31

Immune cells in lens injury repair and fibrosis

Walker, J. L., & Menko, A. S. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108664 · Cited by 26

A Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease

Liu, C., Yang, M., Li, L., Luo, S., Yang, J., Li, C., Liu, J., & Sun, L. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.909569 · Cited by 28

METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis

Chen, Y., Wu, Y., Fang, L., Zhao, H., Xu, S., Shuai, Z., Yu, H., Cai, G., Zhan, H.-Q., & Pan, F. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109838 · Cited by 26

CD4+ T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets

Gao, Y., Lu, Y., Liang, X., Zhao, M., Yu, X., Fu, H., & Yang, W. (2024) · Cells · doi:10.3390/cells13090749 · Cited by 27

Cytosolic Self-DNA—A Potential Source of Chronic Inflammation in Aging

Akbari, M., Shanley, D. P., Bohr, V. A., & Rasmussen, L. J. (2021) · Cells · doi:10.3390/cells10123544 · Cited by 25

Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans: A systematic review and meta‐analysis

Parish, A. J., & Swindell, W. R. (2022) · Aging Cell · doi:10.1111/acel.13733 · Cited by 26

Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway

Duan, C., Hu, J., Zhao, J., Sheng, X., Li, C., Qin, T., He, R., Dai, G., Cao, Y. B., & Lü, H. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360245 · Cited by 24

Transcriptional and metabolic programs promote the expansion of follicular helper T cells in lupus-prone mice

Gong, M., Choi, S., Park, Y. P., Zou, X., Elshikha, A. S., Gerriets, V. A., Rathmell, J. C., Mohamazadeh, M., & Morel, L. M. (2023) · iScience · doi:10.1016/j.isci.2023.106774 · Cited by 24

Molecular mechanism and potential role of mitophagy in acute pancreatitis

Zhu, L., Xu, Y., & Lei, J. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00903-x · Cited by 24

Regulation of immune cell function by nicotinamide nucleotide transhydrogenase

Regan, T., Conway, R., & Bharath, L. P. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00607.2020 · Cited by 24

The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial

Martin, D. E., Cadar, A. N., Panier, H. A., Torrance, B. L., Kuchel, G. A., & Bartley, J. M. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00343-x · Cited by 25

Profiling the metabolome of uterine fluid for early detection of ovarian cancer

Wang, P., Ma, J., Li, W., Wang, Q., Xiao, Y., Jiang, Y., Gu, X., Wu, Y., Dong, S., Guo, H., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101061 · Cited by 25

Integrated or Independent Actions of Metformin in Target Tissues Underlying Its Current Use and New Possible Applications in the Endocrine and Metabolic Disorder Area

Tulipano, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313068 · Cited by 26

DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis

Yang, M., Liu, Y., Luo, S., Liu, C., Jiang, N., Li, C., Zhao, H., Han, Y., Chen, W., Li, L., et al. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01216-1 · Cited by 23

High fructose consumption aggravates inflammation by promoting effector T cell generation via inducing metabolic reprogramming

Ma, X., Chen, J., Wang, F., Fan, X., Li, Z., Liang, H., Cheng, H., Nan, F., Lin, Y., Song, X., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02359-9 · Cited by 29

Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis

Xu, L., Wang, X., Chen, Y., Soong, L., Chen, Y., Cai, J., Liang, Y., & Sun, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.638575 · Cited by 23

Metformin alleviates the depression-like behaviors of elderly apoE4 mice via improving glucose metabolism and mitochondrial biogenesis

Lin, Y., Dai, X., Zhang, J., & Chen, X. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113772 · Cited by 23

Current Status of Autophagy Enhancers in Metabolic Disorders and Other Diseases

Park, K., & Lee, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.811701 · Cited by 24

Role of Mitophagy in the Pathogenesis of Stroke: From Mechanism to Therapy

Zhong, W.-J., Yang, X., Zhou, H., Xie, B.-R., Liu, W., & Li, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6232902 · Cited by 25

Metformin Attenuates Inflammation and Fibrosis in Thyroid-Associated Ophthalmopathy

Xu, Z., Ye, H., Xiao, W., Sun, A., Yang, S., Zhang, T., Sha, X., & Yang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415508 · Cited by 24

Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice

Guo, Y., Wei, J., Liu, C.-J., Li, X., & Yan, W. (2023) · eLife · doi:10.7554/elife.88310 · Cited by 25

Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases

Sun, R., Feng, J., & Wang, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0621 · Cited by 28

STAT3 modulates CD4 +T mitochondrial dynamics and function in aging

Zukowski, E., Sannella, M., Rockhold, J. D., Kalantar, G. H., Yu, J., Calvo, S. S.-C., Kuhn, M. K., Hah, N., Ouyang, L., Wang, T., et al. (2023) · Aging Cell · doi:10.1111/acel.13996 · Cited by 22

The anti‐inflammatory effect of metformin: The molecular targets

Sakata, N. (2024) · Genes to Cells · doi:10.1111/gtc.13098 · Cited by 28

The Role of T Cell Senescence in Neurological Diseases and Its Regulation by Cellular Metabolism

Fessler, J., & Angiari, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.706434 · Cited by 25

Cerium Dioxide Nanoparticles‐Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy

Chen, L., Yang, J., Cai, Z., Huang, Y., Zhang, Q., Zhou, C., Wang, J., Huang, W., Cui, W., & Hu, N. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202405069 · Cited by 22

Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia

Ye, X., Wang, Y., Tian, Y., Bi, R., Li, M., Yang, C., Zhang, L., & Gao, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e27478 · Cited by 21

Redox Homeostasis Involvement in the Pharmacological Effects of Metformin in Systemic Lupus Erythematosus

Teng, X., Brown, J., & Morel, L. M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0070 · Cited by 21

Autophagy takes it all – autophagy inducers target immune aging

Zinecker, H., & Simon, A. K. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049345 · Cited by 22

Towards Healthy Longevity: Comprehensive Insights from Molecular Targets and Biomarkers to Biological Clocks

Yusri, K., Kumar, S., Fong, S., Gruber, J., & Sorrentino, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126793 · Cited by 23

Fisetin Clears Senescent Cells Through the Pi3k‐Akt‐Bcl‐2/Bcl‐xl Pathway to Alleviate Diabetic Aortic Aging

Ji, X., Dong, X., Li, J., Tai, G., Qiu, S., Wei, W., Silumbwe, C. W., Damdinjav, D., Otieno, J. N., Li, X., et al. (2025) · Phytotherapy Research · doi:10.1002/ptr.8507 · Cited by 23

The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy

Yang, J., Tan, C., Wang, Y., Zong, T., Xie, T., Yang, Q., Wu, M., Liu, Y., Mu, T., Wang, X., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166839 · Cited by 20

Broadening Horizons: Exploring mtDAMPs as a Mechanism and Potential Intervention Target in Cardiovascular Diseases

Luan, Y., Luan, Y., Jiao, Y., Liu, H., Huang, Z., Feng, Q., Pei, J., Yang, Y., & Ren, K. (2023) · Aging and Disease · doi:10.14336/ad.2023.1130 · Cited by 21

Wound microenvironment self-adaptive all-in-one hydrogel for rapid healing of the diabetic wound

Li, J., Gao, X., Li, S., Zhang, X., Guo, J., Wang, B., Jin, Y., Zhang, J., Yang, X., & Wang, E. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02426a · Cited by 20

Autophagy modulation in cancer therapy: Challenges coexist with opportunities

Wu, Y., Wang, A., Feng, G., Pan, X., Shuai, W., Yang, P., Zhang, J., Ouyang, L., Luo, Y., & Wang, G. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116688 · Cited by 19

Understanding T cell aging to improve anti-viral immunity

Zhang, H., Weyand, C. M., Goronzy, J. J., & Gustafson, C. E. (2021) · Current Opinion in Virology · doi:10.1016/j.coviro.2021.09.017 · Cited by 18

Clinical consequences of age-related skin barrier dysfunction—Part I: Structural, molecular, and physiologic changes with cutaneous aging

Wahhab, R., Sanders, M., Kokikian, N., Ni, C. S., & Vandiver, A. R. (2024) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2024.08.044 · Cited by 23

The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome

Yan, X., Ma, D., Li, R., Xu, J., Zou, Y., & He, M. (2025) · Endocrine Connections · doi:10.1530/ec-25-0186 · Cited by 19

From Neuron‐Centric to Glia‐Centric: How Aging Glial Networks Drive Neurodegenerative Disease

Hayashide, L. D. S., Pessoa, B., Dias, G. R., Pontes, B., Pinto, R. S., & Diniz, L. P. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70361 · Cited by 19

Autophagy inhibition facilitates wound closure partially dependent on the YAP/IL‐33 signaling in a mouse model of skin wound healing

Gao, Y. Z., Luo, C., Rui, T., Fan, Y., Yao, Y., Shen, H., Gao, C. H., Wang, T., Wang, H., Chen, X., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002623rrr · Cited by 18

Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm

Ma, W., Zhang, J., Liu, S., Yan, S., Xu, K., Zhang, Y. S., Abudupataer, M., Yang, M., Zhu, S., Xiang, B., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104080 · Cited by 19

Cellular senescence: from homeostasis to pathological implications and therapeutic strategies

Li, C., Yuan, Y., Jia, Y., Zhou, Q., Wang, Q., & Jiang, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1534263 · Cited by 21

Potential Nutrients from Natural and Synthetic Sources Targeting Inflammaging—A Review of Literature, Clinical Data and Patents

Koppula, S., Akther, M., Haque, M. E., & Kopalli, S. R. (2021) · Nutrients · doi:10.3390/nu13114058 · Cited by 18

Novel Approach to Skin Anti-Aging: Boosting Pharmacological Effects of Exogenous Nicotinamide Adenine Dinucleotide (NAD+) by Synergistic Inhibition of CD38 Expression

Kang, S., Park, J.-W., Cheng, Z., Ye, S., Jun, S., & Kang, N. G. (2024) · Cells · doi:10.3390/cells13211799 · Cited by 19

Zn2+-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy

He, H., Huang, C., Huang, H., Lan, N., Liu, S., Luo, Y., Zheng, L., Liu, G., Qin, Z., & Zhao, J. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123210 · Cited by 19

Targeting autophagy in aortic aneurysm and dissection

Fang, Z., Feng, X., Chen, Y., Luo, H., Jiang, D., & Yi, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113547 · Cited by 18

Deficiency of IRG1/ itaconate aggravates endotoxemia-induced acute lung injury by inhibiting autophagy in mice

Qiu, J., Zhang, L., Li, K.-X., Zhang, Q., Fan, K., Chen, K., Jiang, Y. L., & Liu, G. (2022) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.22-0104 · Cited by 17

SOCS3 deficiency-dependent autophagy repression promotes the survival of early-stage myeloid-derived suppressor cells in breast cancer by activating the Wnt/mTOR pathway

Zhang, W., Li, X., Jiang, M., Ji, C., Chen, G., Zhang, Q., Liu, P., Zhang, R., Ren, X., Yu, W., et al. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad020 · Cited by 19

Sex-based differences in effector cells of the adaptive immune system during Alzheimer's disease and related dementias

Lutshumba, J., Wilcock, D. M., Monson, N. L., & Stowe, A. M. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106202 · Cited by 20

The development and benefits of metformin in various diseases

Dong, Y., Qi, Y., Jiang, H., Tian, M., Zhang, Y., Peng, C. S., Li, W.-C., Zhang, Y., Zhou, Y., Zang, Y., et al. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-0998-6 · Cited by 21

Metformin Overcomes the Consequences of NKX3.1 Loss to Suppress Prostate Cancer Progression

Papachristodoulou, A., Heidegger, I., Virk, R. K., Di Bernardo, M., Kim, J. Y., Laplaca, C., Picech, F., Schäfer, G., De Castro, G. J., Hibshoosh, H., et al. (2024) · European Urology · doi:10.1016/j.eururo.2023.07.016 · Cited by 18

Old drug, new tricks: the utility of metformin in infection and vaccination responses to influenza and SARS-CoV-2 in older adults

Martin, D. E., Cadar, A. N., & Bartley, J. M. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1272336 · Cited by 21

The Role of Autophagy in Type 2 Diabetic Kidney Disease Management

Tseng, C.-H., Shah, K. M., Chiu, I., & Hsiao, L. (2023) · Cells · doi:10.3390/cells12232691 · Cited by 18

Augmentation of RBP4/STRA6 signaling leads to insulin resistance and inflammation and the plausible therapeutic role of vildagliptin and metformin

Gokulakrishnan, K., Pandey, G. K., Chandrakumar, S., Sundararajan, S., Durairaj, P., Manickam, N., Mohan, V., & Balasubramanyam, M. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06420-y · Cited by 19

Metformin and Malignant Tumors: Not Over the Hill

Leng, W., Jiang, J., Chen, B., & Wu, Q. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s326378 · Cited by 19

Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute toLMNAcardiomyopathy

Sikder, K., Phillips, E., Zhong, Z., Wang, N., Saunders, J., Mothy, D., Kossenkov, A. V., Schneider, T. G., Nichtová, Z., Csordás, G., et al. (2024) · Science Advances · doi:10.1126/sciadv.adh0798 · Cited by 19

Calorie restriction modulates mitochondrial dynamics and autophagy in leukocytes of patients with obesity

Abad‐Jiménez, Z., López‐Domènech, S., Pelechá-Salvador, M., Perea‐Galera, L., Rovira‐Llopis, S., Bañuls, C., Blas‐García, A., Apostolova, N., Morillas, C., Víctor, V. M., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.295 · Cited by 21

Metformin Beyond Diabetes: A Precision Gerotherapeutic and Immunometabolic Adjuvant for Aging and Cancer

Rehman, A., Satyam, S. M., El‐Tanani, M., Prabhakar, S., KUMARI, R. R., Shetty, P., Mohammed, S. S. N., Nafees, Z., & Alomar, B. (2025) · Cancers · doi:10.3390/cancers17152466 · Cited by 20

Will We Unlock the Benefit of Metformin for Patients with Lung Cancer? Lessons from Current Evidence and New Hypotheses

Barrios‐Bernal, P., Zatarain-Barrón, Z. L., Hernández‐Pedro, N., Orozco‐Morales, M., Olivera-Ramírez, A., Ávila‐Moreno, F., Colín-González, A. L., Cardona, A. F., Rosell, R., & Arrieta, O. G. (2022) · Pharmaceuticals · doi:10.3390/ph15070786 · Cited by 18

Molecular Markers of Blood Cell Populations Can Help Estimate Aging of the Immune System

Rybtsova, N., Berezina, T. N., & Александрович, Р. С. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065708 · Cited by 18

Human immunodeficiency virus and antiretroviral therapy-mediated immune cell metabolic dysregulation in children born to HIV-infected women: potential clinical implications

Mataramvura, H., Bunders, M. J., & Duri, K. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1182217 · Cited by 17

Dietary Apigenin Relieves Body Weight and Glycolipid Metabolic Disturbance via Pro‐Browning of White Adipose Mediated by Autophagy Inhibition

Xiong, S., Yu, S., Wang, K., Xiong, X., Xia, M., Zeng, G., & Huang, Q. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200763 · Cited by 17

COVID-19: A Challenge to Physiology of Aging

Golubev, A. G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.584248 · Cited by 18

The Nuclear Lamina: Protein Accumulation and Disease

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Calvo, S. S.-C., Saraswat, S., Kalantar, G. H., Zukowski, E., Marszalkowski, H., Javidan, A., Gholamrezaeinejad, F., Bharath, L. P., Kern, P. A., Zhang, X. D., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01441-4 · Cited by 2

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