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Cited by 474

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

Open access
Zhang, Xiao-Jing, Qin, Juan-Juan, Cheng, Xu, Shen, Lijun, Zhao, Yan-Ci, Yuan, Yufeng, Lei, Fang, Chen, Ming-Ming, Yang, Huilin, Bai, Liangjie, Song, Xiaohui, Lin, Lijin, Xia, Meng, Zhou, Feng, Zhou, Jianghua, She, Zhi-Gang, Zhu, Lihua, Ma, Xinliang, Xu, Qingbo, Ye, Ping, Chen, Guohua, Liu, Liming, Mao, Weiming, Yan, Youqin, Xiao, Bing, Lu, Zhigang, Peng, Gang, Liu, Mingyu, Yang, Jun, Yang, Luyu, Zhang, Changjiang, Lu, Haofeng, Xia, Xigang, Wang, Daihong, Liao, Xiaofeng, Wei, Xiang, Zhang, Bing-Hong, Zhang, Xin, Yang, Juan, Zhao, Guang-Nian, Zhang, Peng, Liu, Peter P., Loomba, Rohit, Ji, Yan-Xiao, Xia, Jiahong, Wang, Yibin, Cai, Jingjing, Guo, Jiao, Li, Hongliang·2020·Cell Metabolism
DOI 10.1016/j.cmet.2020.06.015
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Abstract

Summary Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.

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Metadata

Authors
Zhang, X.-J., Qin, J.-J., Cheng, X., Shen, L., Zhao, Y.-C., Yuan, Y., Lei, F., Chen, M.-M., Yang, H., Bai, L., Song, X., Lin, L., Xia, M., Zhou, F., Zhou, J., She, Z.-G., Zhu, L., Ma, X., Xu, Q., Ye, P., Chen, G., Liu, L., Mao, W., Yan, Y., Xiao, B., Lu, Z., Peng, G., Liu, M., Yang, J., Yang, L., Zhang, C., Lu, H., Xia, X., Wang, D., Liao, X., Wei, X., Zhang, B.-H., Zhang, X., Yang, J., Zhao, G.-N., Zhang, P., Liu, P. P., Loomba, R., Ji, Y.-X., Xia, J., Wang, Y., Cai, J., Guo, J., & Li, H.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2020-08
Volume
32
Issue
2
Pages
176-187.e4
ISSN
1550-4131 (ISSN-L)
DOI
10.1016/j.cmet.2020.06.015
OpenAlex
W3036683212
Cited by
474
References
56
FWCI
12.61
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19. https://app.cochat.ai/papers/10.1016/j.cmet.2020.06.015
The paper
Zhang, X.-J., Qin, J.-J., Cheng, X., Shen, L., Zhao, Y.-C., Yuan, Y., Lei, F., Chen, M.-M., Yang, H., Bai, L., Song, X., Lin, L., Xia, M., Zhou, F., Zhou, J., She, Z.-G., Zhu, L., Ma, X., Xu, Q., . . . Li, H. (2020). In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19. Cell Metabolism. https://doi.org/10.1016/j.cmet.2020.06.015

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.