The benefits of integration
Open accessAbstract
Retroviruses, including the human immunodeficiency virus (HIV), are notorious for two essential steps of their viral replication: reverse transcription and integration. This latter property is considered to be essential for productive replication and ensures the stable long-term insertion of the viral genome sequence in the host chromatin, thereby leading to the life-long association of the virus with the infected cell. Using HIV as a prototypic example, the present review aims to provide an overview of how and where integration occurs, as well as presenting general consequences for both the virus and the infected host.
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In the majority of retroviruses, the process of integration is not random; each class of retrovirus has its characteristic preference.
“In the majority of retroviruses, the process of integration is not random. Each class of retrovirus has its characteristic preference [17, 18].”
From Clinical use of lentiviral vectors (2018) · cites this paper as [18]
The gammaretrovirus MLV exhibits preferential insertion near transcriptional start sites, while the lentivirus HIV preferentially inserts within transcriptional units.
“The gammaretrovirus MLV exhibits preferential insertion near transcriptional start sites, while the lentivirus HIV preferentially inserts within transcriptional units.”
From Clinical use of lentiviral vectors (2018) · cites this paper as [18]
Cites
Shun, M.-C., Raghavendra, N. K., Vandegraaff, N., Daigle, J. E., Hughes, S., Kellam, P., Cherepanov, P., & Engelman, A. (2007) · Genes & Development · doi:10.1101/gad.1565107 · Cited by 467 · see citing works
MLV integration site selection is driven by strong enhancers and active promoters
LaFave, M. C., Varshney, G. K., Gildea, D. E., Wolfsberg, T. G., Baxevanis, A. D., & Burgess, S. M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1399 · Cited by 114 · see citing works
Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration
De Ravin, S. S., Su, L., Theobald, N., Choi, U., Macpherson, J. L., Poidinger, M., Symonds, G., Pond, S. M., Ferris, A. L., Hughes, S. H., et al. (2014) · Journal of Virology · doi:10.1128/jvi.00011-14 · Cited by 103 · see citing works
Demeulemeester, J., De Rijck, J., Gijsbers, R., & Debyser, Z. (2015) · BioEssays · doi:10.1002/bies.201500051 · Cited by 71 · see citing works
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Clinical use of lentiviral vectors
Milone, M. C., & O’Doherty, U. (2018) · Leukemia · doi:10.1038/s41375-018-0106-0 · Cited by 930 · see citing works
- Authors
- Ciuffi, A.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Ciuffi, A.
- ORCID
- Ciuffi, A.
- Venue
- Clinical Microbiology and Infection
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 22
- Issue
- 4
- Pages
- 324-332
- ISSN
- 1198-743X (ISSN-L)
- OpenAlex
- W2336044299
- Cited by
- 27
- References
- 4
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Clinical Microbiology and Infection (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- IRIS (submittedVersion, cc-by-nc-nd)
- Funders
- European Union's Seventh Framework Programme (305762)
- Swiss National Science Foundation (146579)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- retroviral integration, HIV, reverse transcription, viral replication, proviral DNA, viral persistence, retroviruses
- MeSH terms
- Humans, Retroviridae, Virus Integration, Host-Pathogen Interactions
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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