Cited by 245Pharmaceutical Practices and Patient OutcomesPharmacy and Medical PracticesChronic Disease Management Strategies

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Polypharmacy and Medication Management in Older Adults

Kim, Jennifer, Parish, Abby Luck·2017·Nursing Clinics of North America

DOI 10.1016/j.cnur.2017.04.007

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Abstract

Polypharmacy in older adults is a global problem that has recently worsened. Approximately 30% of adults aged 65 years and older in developed countries take 5 or more medications. Although prescribed and over-the-counter medications may improve a wide range of health problems, they also may cause or contribute to harm, especially in older adults. Polypharmacy in older adults is associated with worsening of geriatric syndromes and adverse drug events. Given the risks and burdens of polypharmacy and potentially inappropriate medications, nurses must use patient-centered approaches and nonpharmacologic strategies to treat common symptoms and to optimize patient function and quality of life.

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Background
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“Emergency admission, as opposed to planned admission, has been indicated as a risk factor for 30-day readmission in several studies, including ours, 10 22 and the factor is included in both the HOSPITAL Score 27 and the LACE Index.”
Practice and Policy/Research Implications of Deprescribing on Medication Use and Safety in Older Adults
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Oriental herbal medicine for insomnia in the elderly with hypertension
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“More importantly, the issue of polypharmacy in the elderly population was highlighted recently.([23]) Polypharmacy is described as taking ≥5 medications daily.”
BackgroundSelf-citation
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Tamene, F. B., Zeleke, T. K., Desalew, A. F., Tarekegn, G. Y., Sendekie, A. K., Tafere, S. M., Kiflu, M., Moges, T. A., Dagnew, F. N., & Wondm, S. A. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-025-02011-1 · Cited by 8
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“Prevention of damage due to medication mismanagement is a growing challenge in clinical practice, especially for older adults who are subject to chronic care and the prescription of moremedications (6, 7).”
Background
Association between polypharmacy and chronic kidney disease among community-dwelling older people: a longitudinal study in southern China
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Background
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Air pollution exposure is associated with rhinitis in older US adults via specific immune mechanisms
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Background
Interventions to optimize prescribing for older people in care homes
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Potentially Inappropriate Medication: A Pilot Study in Institutionalized Older Adults
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Background
Evolution of the roles of family physicians through collaboration with rehabilitation therapists in rural community hospitals: a grounded theory approach
Ohta, R., Yoshioka, K., & Sano, C. (2024) · BMC Family Practice · doi:10.1186/s12875-024-02540-z · Cited by 7
“Admitted older patients tend to have multimorbid conditions requiring polypharmacy, and they can develop various medical problems [14]; therefore, organ-specific specialists may be unable to effectively manage such patients [2].”
Background
Tools supporting polypharmacy management in Italy: Factors determining digital technologies' intention to use in clinical practice
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Koubaity, M., Lechon, A.-S., Amighi, K., Nuffelen, M. V., Moreau, M., Meert, A., & Vriese, C. D. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-020-05916-w · Cited by 7
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Background
Downregulated expression of intestinal P-glycoprotein in rats with cisplatin-induced acute kidney injury causes amplification of its transport capacity to maintain “gatekeeper” function
Takeda, F., Oda, M., Terasaki, M., Ichimura, Y., Kojima, H., & Saitoh, H. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115570 · Cited by 7
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Maltais, A., Simard, M., Vedel, I., & Sirois, C. (2022) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000513 · Cited by 6
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Background
Polimedicação em Idosos Submetidos a Tratamento Oncológico
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Over-The-Counter Remedies in Older Adults
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Hirata, I., Hanaoka, S., Rokutanda, R., Funakoshi, R., & Hayashi, H. (2023) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2023.11135 · Cited by 6
“The number of drugs used was classified into two categories based on a previous report on polypharmacy (13).”
Background
The Role of a Clinical Pharmacist in the Identification of Potentially Inadequate Drugs Prescribed to the Geriatric Population in Low-Resource Settings Using the Beers Criteria: A Pilot Study
Kovačević, T., Davidović, M. S., Barišić, V., Fazlić, E., Miljković, S., Djajić, V., Miljković, B., & Kovačević, P. (2024) · Pharmacy · doi:10.3390/pharmacy12030084 · Cited by 6
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BackgroundInfluential
Deprescribing
Diggins, K. C. (2019) · The Nurse Practitioner · doi:10.1097/01.npr.0000554677.33988.af · Cited by 6
What older adults and their caregivers need for making better health-related decisions at home: a participatory mixed methods protocol
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Drug–drug interactions: A descriptive analysis of FDA adverse event reporting system
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District nurses’ experiences of using a clinical decision support system and an assessment tool at elderly care units in primary health care: a qualitative study
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“, 2018), which increases the risk of ADR and drug– drug interactions and has a negative impact on medication adherence (Hughes, 2004; Lagerin et al., 2014; Kim, 2017).”
Background
Prevalência das doenças crônicas não transmissíveis: hipertensão arterial, diabetes mellitus e fatores de risco associados em pessoas idosas longevas
da Silva, A. M., do Carmo, A. S., Alves, V. P., & de Carvalho, L. S. F. (2023) · Revista Brasileira de Enfermagem · doi:10.1590/0034-7167-2022-0592pt · Cited by 5
Elderly patients with comorbid hypertension who prefer primary care have a lower rate of polypharmacy: A cross-sectional study in Shanghai, China
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“Polypharmacy: at present, there is no recognized definition of polypharmacy in the international academic community, and there are still differences in the number and degree of multiple drug uses (16-17).”
Background
Herbal medicine for insomnia in elderly with hypertension: A systematic review and meta-analysis
Kwon, C., Lee, B., Chung, S.-Y., Kim, J. W., & Kim, S.-H. (2019) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2019.100961 · Cited by 5
Self-citation
Comparative Analysis of Drugs Frequently Suspected of Causing Adverse Drug Reactions Reported via the Spontaneous Reporting System Versus in a Prospective Multicentre Cohort Study in Hospital Emergency Departments
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“In addition to PIMs, the increase in the number of drug therapies with increasing age due to comorbidities has been scientifically proven [39–41], and polypharmacy is a significant risk factor for the occurrence of ADRs [42].”
Insomnia and Benzodiazepine Use as Risk Factors for Erectile Dysfunction: Clinical Evidence and In Silico Analysis of Physicochemical Properties
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Factors related to polypharmacy in elderly people assisted by a Family Health Unit in Manhuaçu – MG
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Dietary supplement use is common in older adult drivers: an analysis from the AAA LongROAD study
Moran, R. J., Baird, S., DiGuiseppi, C. G., Eby, D. W., Hacker, S., Isom, C. A., Jones, V., Lee, K. C., Li, G., Molnar, L. J., et al. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04623-x · Cited by 4
Development and validation of the discharge severity index for post-emergency department hospital readmissions
Kijpaisalratana, N., Ariss, A.-B., Balk, A., Mitragotri, S., Samadian, K. D., Hahn, B. J., Coleska, A., Baugh, J. J., Hassan, A., Lee, J., et al. (2025) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2025.04.045 · Cited by 4

Authors: Kim, J., & Parish, A. L.
Affiliations: Vanderbilt University (US)
Corresponding author: Kim, Jennifer
ORCID: Parish, Abby Luck
Venue: Nursing Clinics of North America
Publisher: Elsevier BV
Published: 2017-09
Volume: 52
Issue: 3
Pages: 457-468
ISSN: 0029-6465 (ISSN-L)
DOI: 10.1016/j.cnur.2017.04.007
OpenAlex: W2739733993
Cited by: 245
References: 45
Citations by year: 2026: 15 · 2025: 28 · 2024: 47 · 2023: 44 · 2022: 34 · 2021: 38 · 2020: 15 · 2019: 18 · 2018: 6
FWCI: 1.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Nursing Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Keywords: polypharmacy, older adults, medication management, potentially inappropriate medications, adverse drug reactions, geriatric syndromes, patient-centered care, non-pharmacological treatment, quality of life, nursing care
MeSH terms: Aged, Humans, Polypharmacy, Nurse's Role, Medication Therapy Management, Drug-Related Side Effects and Adverse Reactions

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Polypharmacy and Medication Management in Older Adults

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