The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Immunological synapse and microclusters: the site for recognition and activation of T cells
Abstract
An immunological synapse (IS) is formed at the interface between antigen-presenting cells and T cells, and is believed to be the structure responsible for antigen recognition and T-cell activation. However, recent imaging analyses reveal that T-cell receptor microclusters (MCs) formed prior to IS are the site for antigen recognition and T-cell activation. MCs are continuously generated at the periphery of the interface, even after IS formation, and induce sustained activation signals. MC formation is not accompanied by lipid-raft clustering. Central supramolecular activation cluster is considered functional in recycling and degradation of T-cell receptors, directional secretion of cytokines and cytolytic granules, generation of sustained signals, or maintenance of the cell-cell conjugation.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Lck and ZAP-70 have been shown to translocate to microclusters of receptors and signaling molecules in the peripheral regions of the T-APC interface within lipid rafts during initiation of the TCR activation signal. The clusters form a central supramolecular activation cluster (c-SMAC) of the IS [24], [25], [26].”
From RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling (2010) · cites this paper as [26]
Citations
Cites
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Grakoui, A., Bromley, S. K., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (1999) · Science · doi:10.1126/science.285.5425.221 · Cited by 3,110
Three-dimensional segregation of supramolecular activation clusters in T cells
Monks, C. R. F., Freiberg, B. A., Kupfer, H., Sciaky, N., & Kupfer, A. (1998) · Nature · doi:10.1038/25764 · Cited by 1,968
T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
Mempel, T. R., Henrickson, S. E., & von Andrian, U. H. (2004) · Nature · doi:10.1038/nature02238 · Cited by 1,771
CTLA-4–Ig regulates tryptophan catabolism in vivo
Grohmann, U., Orabona, C., Fallarino, F., Vacca, C., Calcinaro, F., Falorni, A., Candeloro, P., Belladonna, M. L., Bianchi, R., Fioretti, M. C., et al. (2002) · Nature Immunology · doi:10.1038/ni846 · Cited by 1,161
Bromley, S. K., Burack, R., Johnson, K. G., Somersalo, K., Sims, T. N., Sumen, C., Davis, M. M., Shaw, A. S., Allen, P. M., & Dustin, M. L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.375 · Cited by 979
Direct observation of ligand recognition by T cells
Irvine, D. J., Purbhoo, M. A., Krogsgaard, M., & Davis, M. M. (2002) · Nature · doi:10.1038/nature01076 · Cited by 824
Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor
Janes, P. W., Ley, S. C., & Magee, A. I. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.447 · Cited by 797
Douglass, A. D., & Vale, R. D. (2005) · Cell · doi:10.1016/j.cell.2005.04.009 · Cited by 743
Yokosuka, T., Sakata-Sogawa, K., Kobayashi, W., Hiroshima, M., Hashimoto-Tane, A., Tokunaga, M., Dustin, M. L., & Saito, T. (2005) · Nature Immunology · doi:10.1038/ni1272 · Cited by 698
Self-citationT Cell Receptor Signaling Precedes Immunological Synapse Formation
Lee, K., Holdorf, A. D., Dustin, M. L., Chan, A. C., Allen, P. M., & Shaw, A. S. (2002) · Science · doi:10.1126/science.1067710 · Cited by 684
Cited by
Yokosuka, T., Takamatsu, M., Kobayashi-Imanishi, W., Hashimoto-Tane, A., Azuma, M., & Saito, T. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112741 · Cited by 1,161
Self-citationClayton, K. L., Haaland, M. S., Douglas-Vail, M. B., Mujib, S., Chew, G. M., Ndhlovu, L. C., & Ostrowski, M. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302663 · Cited by 134
The virological synapse facilitates herpes simplex virus entry into T cells
Aubert, M., Yoon, M., Sloan, D. D., Spear, P. G., & Jerome, K. R. (2009) · Journal of Virology · doi:10.1128/jvi.02163-08 · Cited by 52
RhoH Regulates Subcellular Localization of ZAP-70 and Lck in T Cell Receptor Signaling
Chae, H.-D., Siefring, J. E., Hildeman, D. A., Gu, Y., & Williams, D. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013970 · Cited by 35
Manna, A., Zhao, H., Wada, J., Balagopalan, L., Tagad, H. D., Appella, E., Schuck, P., & Samelson, L. E. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817142115 · Cited by 24
Liu, H., Purbhoo, M. A., Davis, D. M., & Rudd, C. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909112107 · Cited by 18
Metadata
- Authors
- Saito, T., & Yokosuka, T.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 18
- Issue
- 3
- Pages
- 305-313
- ISSN
- 0952-7915
- Cited by
- 124
- References
- 68
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
