Cited by 124

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Immunological synapse and microclusters: the site for recognition and activation of T cells

Saito, Takashi, Yokosuka, Tadashi·2006·Current Opinion in Immunology

DOI 10.1016/j.coi.2006.03.014

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Abstract

An immunological synapse (IS) is formed at the interface between antigen-presenting cells and T cells, and is believed to be the structure responsible for antigen recognition and T-cell activation. However, recent imaging analyses reveal that T-cell receptor microclusters (MCs) formed prior to IS are the site for antigen recognition and T-cell activation. MCs are continuously generated at the periphery of the interface, even after IS formation, and induce sustained activation signals. MC formation is not accompanied by lipid-raft clustering. Central supramolecular activation cluster is considered functional in recycling and degradation of T-cell receptors, directional secretion of cytokines and cytolytic granules, generation of sustained signals, or maintenance of the cell-cell conjugation.

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See all 124

Authors: Saito, T., & Yokosuka, T.
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2006-06
Volume: 18
Issue: 3
Pages: 305-313
ISSN: 0952-7915
DOI: 10.1016/j.coi.2006.03.014
Cited by: 124
References: 68
Language: en
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)

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Immunological synapse and microclusters: the site for recognition and activation of T cells

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