Molecular events that regulate αβ versus γδ T cell lineage commitment: old suspects, new players and different game plans
Abstract
The divergence of alphabeta and gammadelta T cells from a common precursor in the thymus is regulated by multiple cell-intrinsic and cell-extrinsic factors, most of which are not well defined. Recent studies have provided crucial data regarding the precise timing of lineage commitment and some clarification on the extent of the involvement of Notch and T-cell receptor signaling in this process. Combined with new insights into the differential regulation of molecular pathways active in alphabeta and gammadelta precursors, these data have led to the generation of a revised model of lineage commitment.
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γδ T cell commitment during DN T cell development may occur at several stages.
“Although γδ T cell commitment during DN T cell development may occur at several stages [24]”
From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [24]
Cites
Taghon, T., Yui, M. A., Pant, R., Diamond, R. A., & Rothenberg, E. V. (2006) · Immunity · doi:10.1016/j.immuni.2005.11.012 · Cited by 312 · see citing works
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The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis
Jabeen, R., Chang, H.-C., Goswami, R., Nutt, S. L., & Kaplan, M. H. (2011) · PLOS ONE · doi:10.1371/journal.pone.0022189 · Cited by 10 · see citing works
- Authors
- Narayan, K., & Kang, J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Kang, Joonsoo
- ORCID
- Kang, Joonsoo
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 19
- Issue
- 2
- Pages
- 169-175
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2023441364
- Cited by
- 12
- References
- 1
- Citations by year
- 2022: 2 · 2012: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA100382, CA92614, CA100382, R01CA092614)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- alpha beta T cells, γδ T cells, T cell lineage commitment, thymus development, Notch signaling, T cell receptor signaling, T cell precursors
- MeSH terms
- Animals, T-Lymphocytes, Thymus Gland, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Antigen, T-Cell, alpha-beta, Cell Lineage, Lymphopoiesis, Multipotent Stem Cells, Mice, Receptors, Notch
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