Developmental and Molecular Characterization of Emerging β- and γδ-Selected Pre-T Cells in the Adult Mouse Thymus

Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro

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Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

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CD5 Expression Is Developmentally Regulated By T Cell Receptor (TCR) Signals and TCR Avidity

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Thymopoiesis independent of common lymphoid progenitors.

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T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

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Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages.

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Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

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Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

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Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

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Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.Preprint

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Maintenance of T Cell Specification and Differentiation Requires Recurrent Notch Receptor–Ligand Interactions

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Regulation of αβ/γδ T Cell Lineage Commitment and Peripheral T Cell Responses by Notch/RBP-J Signaling

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Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

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TCR Signal Strength Influences αβ/γδ Lineage Fate

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NF-κB Activation by the Pre-T Cell Receptor Serves as a Selective Survival Signal in T Lymphocyte Development

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Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.

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Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control Points

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Attenuation of γδTCR Signaling Efficiently Diverts Thymocytes to the αβ Lineage

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Functions of E2A-HEB Heterodimers in T-Cell Development Revealed by a Dominant Negative Mutation of HEB

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Regulation of Thymus Size by Competition for Stromal Niches among Early T Cell Progenitors

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The IL-7 Receptor Controls the Accessibility of the TCRγ Locus by Stat5 and Histone Acetylation

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Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

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Notch ligands Delta1 and Jagged1 transmit distinct signals to T-cell precursors

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Characterization of TCR Gene Rearrangements During Adult Murine T Cell Development

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Different initiation of pre-TCR and γδTCR signalling

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The CD8α Gene Locus Is Regulated by the Ikaros Family of Proteins

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Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signalingPreprint

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Lymphotoxin-Mediated Regulation of γδ Cell Differentiation by αß T Cell Progenitors

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Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins

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The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells

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Premature Expression of T Cell Receptor (Tcr)αβ Suppresses Tcrγδ Gene Rearrangement but Permits Development of γδ Lineage T Cells

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Branching out to gain control: how the pre-TCR is linked to multiple functions

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Notch-Regulated Ankyrin-Repeat Protein Inhibits Notch1 Signaling: Multiple Notch1 Signaling Pathways Involved In T Cell Development

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Intrathymic δ Selection Events in γδ Cell Development

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Commitment to the T cell receptor‐αβ or ‐γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes

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Active Form of Notch Imposes T Cell Fate in Human Progenitor Cells

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Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.

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Surface Expression of Notch1 on Thymocytes: Correlation with the Double-Negative to Double-Positive Transition

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TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development.

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Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

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Overexpression of the Runx3 Transcription Factor Increases the Proportion of Mature Thymocytes of the CD8 Single-Positive Lineage

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On the brink of becoming a T cell

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Stepwise specification of lymphocyte developmental lineages

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Exogenous IL-7 promotes the growth of CD3-CD4-CD8-CD44+CD25+/- precursor cells and blocks the differentiation pathway of TCR-alpha beta cells in fetal thymus organ culture

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A New Regulatory Region of the IL-2 Locus That Confers Position-Independent Transgene Expression

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T/NK Bipotent Progenitors in the Thymus Retain the Potential to Generate Dendritic Cells

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Enforced Expression of Spi-B Reverses T Lineage Commitment and Blocks β-Selection

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Deranged Early T Cell Development in Immunodeficient Strains of Nonobese Diabetic Mice

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A B-myb Promoter Corepressor Site Facilitatesin Vivo Occupation of the Adjacent E2F Site by p107·E2F and p130·E2F Complexes

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphomaPreprint

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CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

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Notch Signaling in the Immune System

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Launching the T-cell-lineage developmental programme

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Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus

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A critical role for TCF-1 in T-lineage specification and differentiation

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

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Regulation of innate and adaptive immunity by Notch

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Developmental gene networks: a triathlon on the course to T cell identity

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Decision checkpoints in the thymus

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The multifaceted role of Notch in cancer

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Mechanisms of T Cell Development and Transformation

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The transcriptional landscape of αβ T cell differentiation

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Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation

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Transcriptional Control of Early T and B Cell Developmental Choices

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The thymus as an inductive site for T lymphopoiesis.

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Visualization of the earliest steps of γδ T cell development in the adult thymus

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The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor

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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2APreprint

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E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

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Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3

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Determining γδ versus αβ T cell development

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Functions of Notch Signaling in the Immune System: Consensus and Controversies

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Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint

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Development of Promyelocytic Zinc Finger and ThPOK-Expressing Innate γδ T Cells Is Controlled by Strength of TCR Signaling and Id3

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Fine-Scale Staging of T Cell Lineage Commitment in Adult Mouse Thymus

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γδ T Cells and Their Potential for Immunotherapy

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