The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Pattern recognition receptors in the immune response against dying cells
Abstract
Pattern recognition receptors (PRR), immune sensors that discriminate self from non-self, link innate to adaptive immunity. PRR are involved in microbe internalization by phagocytes (soluble PRR and endocytic receptors) and/or cell activation (signaling PRR). PRR also recognize dying cells (i.e. modified self). Apoptotic cell recognition involves soluble bridging molecules (e.g. pentraxins) and endocytic receptors (e.g. scavenger receptors, the CD91-calreticulin complex). Apoptotic cells induce an immunosuppressive signal, avoiding the initiation of an autoimmune response. By contrast, necrotic cells, via the release of stimulatory molecules [heat shock protein (HSP), high-mobility group box 1 protein (HMGB1)], activate immune cells. This review summarizes the PRR involved in the recognition of dying cells and the consequences on the outcome of the immune response directed against dying cell antigens.
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“Although the molecular circuitry of pyroptosis (which is often induced by intracellular bacteria) has been investigated in vitro 107, no data are available on the immunogenicity of pyroptosis in vivo.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [107]
In the citing paper
“Moreover, PRR present on or within DC include a group of signaling receptors that stimulate the post uptake reactions (including toll-like receptors, NOD-like receptors, and RIG1-like helicases)52,107.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [107]
In the citing paper
“Pyroptosis involves the crucial contribution of a particular set of caspase-1 activating complexes, known as the inflammasomes.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [107]
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Metadata
- Authors
- Jeannin, P., Jaillon, S., & Delneste, Y.
- Affiliations
- Inserm (FR)
- Corresponding author
- Jeannin, Pascale
- Jaillon, Sébastien
- Delneste, Yves
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 20
- Issue
- 5
- Pages
- 530-537
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2092996173
- Cited by
- 165
- References
- 74
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 17 · 2015: 10 · 2014: 12 · 2013: 19 · 2012: 13
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Keywords
- pattern recognition receptors, dying cells, apoptotic cell recognition, necrotic cell clearance, pentraxins, scavenger receptors, immunosuppression, autoimmunity, HMGB1, heat shock proteins, innate-adaptive immune crosstalk, endocytic receptor
- MeSH terms
- Ficolins, Acute-Phase Proteins, Animals, Humans, Lymphocyte Activation, Apoptosis, Lipopolysaccharide Receptors, Lectins, Collectins, Receptors, Scavenger, Receptors, Pattern Recognition
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