The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Sensing pathogens and danger signals by the inflammasome
Open accessAbstract
The NLR (nucleotide-binding domain leucine-rich repeat containing) family of intracellular sensors is a crucial component of the innate immune system. A number of NLR family members can form multiprotein complexes, called inflammasomes, and are capable of activating the cysteine protease caspase-1 in response to a wide range of stimuli including both microbial and self-molecules. Caspase-1 activation leads to processing and secretion of the proinflammatory cytokines interleukin-1beta (IL-1beta) and IL-18, which play crucial roles in host defense to infectious insults. Dysregulation of the inflammasome has also been linked to a number of autoinflammatory and autoimmune disorders. Recent advances in the inflammasome field will be discussed in this review.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Proinflammatory danger signals induce activity of a multiprotein complex called the Nod-like receptor protein (NLRP)-3 inflammasome (16–18).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [18]
In the citing paper
“During inflammasome activation, the proform of caspase-1 is recruited to the NLRP-3 complex and cleaved to produce active caspase-1, which then cleaves and activates the potent proinflammatory cytokines IL-1β and IL-18.”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864
Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–233 of 233
Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression
Singhal, G., & Baune, B. T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00009-x · Cited by 1
Sun, J., Zhao, X., Pei, C., Zhu, L., Zhang, J., & Kong, X. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.108452 · Cited by 1
Biochemical and Functional Characterization of the Mitochondrial Immune Signaling Protein Complex
Lei, Y. L. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/sr3j-8s02 · Cited by 1
Regulation of silica-induced pulmonary inflammation
Biswas, R. (2014) · ProQuest Demo Repository · Cited by 1
Liepina, I. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Ubiquitin Dependent Regulation of Innate Antiviral Signaling
Parvatiyar, M. S. (2010)
The mannose receptor in macrophage biology
Gazi, U. (2010) · Nottingham ePrints (University of Nottingham)
Phalane, K. G. (2013) · SUNScholar (Stellenbosch University)
INNATE IMMUNE SENSING OF A BACTERIAL PORE-FORMING TOXIN: THE ROLE OF THE NLRP3 INFLAMMASOME
Chu, J. (2010) · D-Scholarship@Pitt (University of Pittsburgh)
Targeting Toll-Like Receptors: a step closer to effective recombinant subunit vaccines
Bendelja, K., & Rabatić, S. (2012) · University of Zagreb University Computing Centre (SRCE)
Inflammasome activation in human and mouse macrophages engulfing autophagic dying cells
Duran, G. A. (2012) · University of Debrecen Electronic Archive (University of Debrecen)
UNIVERSIDADE FEDERAL DE GOIÁS PROGRAMA DE PÓS-GRADUAÇÃO EM MEDICINA TROPICAL
Pública, E. S., Ribeiro, P. M. A., & Pacheco, G. (2010)
López-Yglesias, A. H. (2014) · ResearchWorks at the University of Washington (University of Washington)
Tumor-Like Granulomatous Disorders of the Hepatobiliary Tract
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26587-2_139-1
de Jong, H. K., & Wiersinga, W. J. (2016) · Wiley eBooks · doi:10.1002/9780470015902.a0001210.pub2
Wynick, C. (2014) · QSpace (Queen's University Library)
Robson, S. C., Mehal, W. Z., Hoque, R., Sohail, M. A., Salhanick, S. D., Malik, A. F., & Ghani, A. (2013)
Papel da endotelina-1 na ativação do NLRP3 no tecido muscular liso do corpo cavernoso
Fais, R. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2017.tde-21072016-161830
Ketelut-Carneiro, N. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-08062017-093404
Mesenchymal Stem Cell–Based Therapy for Chronic Kidney Disease
Irazabal, M. V., Hickson, L. J., & Eirin, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811920-4.00011-2
FLUORESENCE MICROSCOPY OF NLR INFLAMMASOME INTERACTIONS
Kandimalla, B. (2012)
Role of NLRP3 Inflammasomes in Obesity-Induced Cardiovascular Diseases
Boini, K. M., Li, P., & Koka, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-47336-5_5
Fais, R. S. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2020.tde-05062020-084655
Padilha, M. D. M., Ramos, S. A. A., Duarte, A. C., de Sousa, R. M., Balcázar, O. D. A., Machado, C. L. R., Pimentel, C. P., Hirai, K. E., da Costa, G. M., & Holanda, G. M. (2022) · Revista Eletrônica Acervo Saúde · doi:10.25248/reas.e9959.2022 · Cited by 1
Tumor-Like Granulomatous Disorders of the Hepatobiliary Tract
Zimmermann, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-26956-6_139
The Role of Microbiome in Nonalcoholic Fatty Liver Disease
Lee, H. W. (2023) · Springer eBooks · doi:10.1007/978-981-19-4492-5_7
Zou, Y., Bai, S., Han, M., Yang, X., Cheng, X., Wu, J., Xia, Z., & Yang, R. (2025) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2025.104021
Chojnacki, J. E. (2014) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/62wy-9639
Heid, M. E. (2013) · D-Scholarship@Pitt (University of Pittsburgh)
Metadata
- Authors
- Pedra, J. H., Cassel, S. L., & Sutterwala, F. S.
- Affiliations
- University of California, Riverside (US)
- University of Iowa (US)
- Corresponding author
- Pedra, Joao HF
- Sutterwala, Fayyaz S
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 21
- Issue
- 1
- Pages
- 10-16
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC2701640
- OpenAlex
- W2171309698
- Cited by
- 233
- References
- 65
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 12 · 2018: 13 · 2017: 8 · 2016: 19 · 2015: 11 · 2014: 20 · 2013: 22 · 2012: 29
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Centers for Disease Control and Prevention (K01CK000101)
- National Institute of Allergy and Infectious Diseases (K08AI067736, K08AI065517)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- inflammasome, caspase-1 activation, IL-1β, IL-18, innate immunity, pathogen recognition, damage-associated molecular patterns, autoinflammatory disease, autoimmune disease, host defense
- MeSH terms
- NLR Proteins, Animals, Autoimmune Diseases, Bacterial Infections, Calcium-Binding Proteins, Gene Expression Regulation, Humans, Immunity, Innate, Polymorphism, Genetic, Signal Transduction, Genetic Predisposition to Disease, Caspase 1, Intercellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, CARD Signaling Adaptor Proteins, Interleukin-1beta, Host-Pathogen Interactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
