The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Sensing pathogens and danger signals by the inflammasome
Open accessAbstract
The NLR (nucleotide-binding domain leucine-rich repeat containing) family of intracellular sensors is a crucial component of the innate immune system. A number of NLR family members can form multiprotein complexes, called inflammasomes, and are capable of activating the cysteine protease caspase-1 in response to a wide range of stimuli including both microbial and self-molecules. Caspase-1 activation leads to processing and secretion of the proinflammatory cytokines interleukin-1beta (IL-1beta) and IL-18, which play crucial roles in host defense to infectious insults. Dysregulation of the inflammasome has also been linked to a number of autoinflammatory and autoimmune disorders. Recent advances in the inflammasome field will be discussed in this review.
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“Proinflammatory danger signals induce activity of a multiprotein complex called the Nod-like receptor protein (NLRP)-3 inflammasome (16–18).”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [18]
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“During inflammasome activation, the proform of caspase-1 is recruited to the NLRP-3 complex and cleaved to produce active caspase-1, which then cleaves and activates the potent proinflammatory cytokines IL-1β and IL-18.”
From Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice (2014) · cites this paper as [18]
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Cites
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Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,864
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How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679
Cited by
Sorted by citations
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
Schroder, K., Zhou, R., & Tschopp, J. (2010) · Science · doi:10.1126/science.1184003 · Cited by 1,153
Dendritic cell-based immunotherapy
Sabado, R. L., Balan, S., & Bhardwaj, N. (2016) · Cell Research · doi:10.1038/cr.2016.157 · Cited by 942
Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes
Lee, H., Kim, J.-J., Kim, H. J., Shong, M., Ku, B. J., & Jo, E. (2012) · Diabetes · doi:10.2337/db12-0420 · Cited by 745
Martínez‐Pomares, L. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0512231 · Cited by 563
Metadata
- Authors
- Pedra, J. H., Cassel, S. L., & Sutterwala, F. S.
- Affiliations
- University of California, Riverside (US)
- University of Iowa (US)
- Corresponding author
- Pedra, Joao HF
- Sutterwala, Fayyaz S
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 21
- Issue
- 1
- Pages
- 10-16
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC2701640
- OpenAlex
- W2171309698
- Cited by
- 233
- References
- 65
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 12 · 2018: 13 · 2017: 8 · 2016: 19 · 2015: 11 · 2014: 20 · 2013: 22 · 2012: 29
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Centers for Disease Control and Prevention (K01CK000101)
- National Institute of Allergy and Infectious Diseases (K08AI067736, K08AI065517)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- inflammasome, caspase-1 activation, IL-1β, IL-18, innate immunity, pathogen recognition, damage-associated molecular patterns, autoinflammatory disease, autoimmune disease, host defense
- MeSH terms
- NLR Proteins, Animals, Autoimmune Diseases, Bacterial Infections, Calcium-Binding Proteins, Gene Expression Regulation, Humans, Immunity, Innate, Polymorphism, Genetic, Signal Transduction, Genetic Predisposition to Disease, Caspase 1, Intercellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, CARD Signaling Adaptor Proteins, Interleukin-1beta, Host-Pathogen Interactions
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