Cited by 481Immunotherapy and Immune ResponsesImmune responses and vaccinationsHIV Research and Treatment

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Heterologous prime-boost vaccination

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Lu, Shan·2009·Current Opinion in Immunology

DOI 10.1016/j.coi.2009.05.016PMC PMC3743086

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Abstract

An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost. Heterologous prime-boost represents a new way of immunization and will stimulate better understanding on the immunological basis of vaccines.

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Authors: Lu, S.
Affiliations: Jiangsu Province Hospital (CN)
Corresponding author: Lu, Shan
ORCID: Lu, Shan
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2009-06
Volume: 21
Issue: 3
Pages: 346-351
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2009.05.016
PMC: PMC3743086
OpenAlex: W1979742563
Cited by: 481
References: 40
Citations by year: 2026: 15 · 2025: 25 · 2024: 21 · 2023: 32 · 2022: 66 · 2021: 53 · 2020: 41 · 2019: 28 · 2018: 17 · 2017: 27 · 2016: 13 · 2015: 18 · 2014: 21 · 2013: 34 · 2012: 18
FWCI: 1.81
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (P01AI082274, R01AI065250, R01 AI06250, U19AI082676)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: heterologous prime-boost, prime-boost vaccination, vaccine immunogenicity, vaccine adjuvants
MeSH terms: Animals, Humans, Immunization, Secondary, Neoplasms, Research, Research Design, Vaccination, HIV Infections, AIDS Vaccines, Cancer Vaccines

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