The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Heterologous prime-boost vaccination
Open accessAbstract
An effective vaccine usually requires more than one time immunization in the form of prime-boost. Traditionally the same vaccines are given multiple times as homologous boosts. New findings suggested that prime-boost can be done with different types of vaccines containing the same antigens. In many cases such heterologous prime-boost can be more immunogenic than homologous prime-boost. Heterologous prime-boost represents a new way of immunization and will stimulate better understanding on the immunological basis of vaccines.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although adenoviral vectors might induce immune responses against vector components and attenuate antigen-induced responses, prime-boost heterologous vaccination with two different vectors allows minimisation of this effect.9, 10, 11”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Shiver, J. W., Fu, T., Chen, L., Casimiro, D. R., Davies, M.-E., Evans, R. K., Zhang, Z., Simon, A. J., Trigona, W. L., Dubey, S. A., et al. (2002) · Nature · doi:10.1038/415331a · Cited by 1,173
Control of a Mucosal Challenge and Prevention of AIDS by a Multiprotein DNA/MVA Vaccine
Amara, R. R. (2001) · Science · doi:10.1126/science.1058915 · Cited by 1,110
The prime-boost strategy: exciting prospects for improved vaccination
Ramshaw, I. A., & Ramsay, A. J. (2000) · Immunology Today · doi:10.1016/s0167-5699(00)01612-1 · Cited by 373
Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus.
Girard, M. P., Kiény, M. P., Pinter, A., Barré‐Sinoussi, F., Nara, P. L., Kolbe, H. V. J., Kusumi, K., Chaput, A., Reinhart, T. A., & Muchmore, E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.542 · Cited by 353
Protection of Macaques Against SIV Infection by Subunit Vaccines of SIV Envelope Glycoprotein gp160
Hu, S.-L., Abrams, K., Barber, G. N., Moran, P. A., Zarling, J. M., Langlois, A. J., Kuller, L., Morton, W. R., & Benveniste, R. Ė. (1992) · Science · doi:10.1126/science.1531159 · Cited by 335
Kent, S. J., Zhao, A., Best, S. J., Chandler, J. D., Boyle, D. B., & Ramshaw, I. A. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.10180-10188.1998 · Cited by 325
Hanke, T., Samuel, R. V., Blanchard, T. J., Neumann, V. C., Allen, T. M., Boyson, J. E., Sharpe, S. A., Cook, N. M., Smith, G. L., Watkins, D. I., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7524-7532.1999 · Cited by 304
Harari, A., Bart, P., Stöhr, W., Tapia, G., Garcia, M., Medjitna-Rais, E., Burnet, S., Cellerai, C., Erlwein, O. W., Barber, T., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071331 · Cited by 299
Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides
Emini, E. A., Jameson, B. A., & Wimmer, E. (1983) · Nature · doi:10.1038/304699a0 · Cited by 237
Zagury, D., Bernard, J., Cheynier, R., Desportes, I., Leonard, R., Fouchard, M., Réveil, B., Ittelé, D., Lurhuma, Z., Mbayo, K., et al. (1988) · Nature · doi:10.1038/332728a0 · Cited by 185
Cited by
Sorted by citations
Items 401–480 of 480
Progress in development and application of H5/H7 avian influenza vaccines in China
Zeng, X., GuoBin, T. I. A. N., & HuaLan, C. H. E. N. (2023) · Scientia Sinica Vitae · doi:10.1360/ssv-2023-0144 · Cited by 1
Ávila‐Nieto, C., Vergara‐Alert, J., Amengual-Rigo, P., Ainsua‐Enrich, E., Brustolin, M., de la Concepción, M. L. R., Pedreño-López, N., Rodon, J., Urrea, V., Pradenas, E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46714-w · Cited by 1
Hammadi, A. A. K. A., Alzaabi, A. A., Choker, H. B., Ibrahim, A. A., Ishaq, A., Mahboub, A. E., Dhaheri, R. S. A., Alzaabi, M. N., Collyns, T. A., ElGhazali, G. E., et al. (2025) · Vaccine X · doi:10.1016/j.jvacx.2025.100698 · Cited by 1
Antibody Responses Elicited by DNA Prime-Protein Boost HIV Vaccines: A Dissertation
Vaine, M. (2010) · eScholarship@UMassChan · doi:10.13028/ypgp-5r25 · Cited by 1
DNA Vaccines in Pigs: From Immunization to Antigen Identification
Accensi, F., Bosch-Camós, L., Monteagudo, P. L., & Rodrı́guez, F. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2168-4_6 · Cited by 1
Human Immunodeficiency Virus Vaccines
Girard, M. P., & Koff, W. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35761-6.00029-8 · Cited by 2
Requirements for the Induction of Broadly Neutralizing Antibodies against HIV-1 by Vaccination
Vzorov, A. N., & Lv, U. (2017) · Molecular Biology · doi:10.1134/s0026893317060176 · Cited by 1
A Comprehensive Review of Vaccines against Covid-19
Minh, P. H., Linh, V. K., Hải, N. T., & Tùng, B. T. (2021) · VNU Journal of Science Medical and Pharmaceutical Sciences · doi:10.25073/2588-1132/vnumps.4365 · Cited by 1
SARS-CoV-2 antibodies among health care workers from a children’s hospital
Svartz, A., Rial, M. J., Insúa, C., Stedile, G., Haleblian, E., Peverini, A., & Brunetto, O. (2022) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2022-02595.eng · Cited by 1
Rao, J. (2021) · Open Access Journal of Pharmaceutical Research · doi:10.23880/oajpr-16000234
Bayesian inference for prediction of survival probability in prime‐boost vaccination regimes
Lu, Y., Carlin, B. P., & Seaman, J. W. (2023) · Statistics in Medicine · doi:10.1002/sim.9972 · Cited by 1
Rift Valley fever : development of diagnostics and vaccines
Näslund, J. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Alphavirus replicon-based strategies for vaccination
Knudsen, M. (2014) · Figshare · Cited by 1
A novel strategy to express different antigens from one modified vaccinia Ankara vaccine vectorPreprint
Lauer, K. B., McKenzie, E. A., Hall, Y., Gowda, C. P. C., Klapper, P. E., Borrow, R., Vallely, P. J., Carroll, M. W., & Blanchard, T. J. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/191924 · Cited by 1
Two urgent needs in the battle against COVID-19Preprint
Franco, R., & Serrano‐Marín, J. (2021) · doi:10.31219/osf.io/8fkbg · Cited by 1
Hu, S., & Ho, R. J. Y. (2013) · doi:10.1002/9781118660485.ch14 · Cited by 1
Harwood, O. E., Balgeman, A. J., Weaver, A. J., Ellis-Connell, A. L., Weiler, A. M., Erickson, K. N., Matschke, L. M., Golfinos, A. E., Vezys, V., Skinner, P. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.08.499199 · Cited by 1
Pérez, C. L. (2011) · Figshare
Buglione‐Corbett, R., Suschak, J. J., Wang, S., & Lu, S. (2013) · Wiley eBooks · doi:10.1002/9780470571224.pse516
Self-citationEspíndola, M. S. (2011) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2011.tde-02062011-105929
Roles in innate immune receptors: Host : pathogen interactions and strengthening vaccines
Nyström, S. (2013) · Figshare
Antunes, D. A. (2011) · Americanae (AECID Library)
Besser Impfen – neue Wege zur gezielten Immunmodulation bei Gesunden und Immunsupprimierten
Balmer, M. L., & Berger, C. T. (2014) · Therapeutische Umschau · doi:10.1024/0040-5930/a000476
Mucosal immunity against mycobacterial infection
Rahman, M. J. (2010) · DiVA (Stockholm University)
Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
Hollister, K. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1738
Follicular Helper, Follicular Regulatory T cells and the Germinal Center In HIV Vaccine Development
Dent, A. L. (2015) · International Journal of Vaccines and Immunization · doi:10.16966/2470-9948.e101
Aldrich, J. F. (2012) · ThinkTech (Texas Tech University)
Development and clinical translation of microneedles for insulin delivery and self-vaccination
Norman, J. J. (2012) · SMARTech Repository (Georgia Institute of Technology)
Luna‐Palomera, C., González-González, J., Gayosso-Vázquez, A., Ramírez-Andoney, V., Ojeda-Robertos, N. F., Cabrales, J. A. A., & Alonso-Morales, R. A. (2018) · Nova Scientia · doi:10.21640/ns.v10i20.1310
Nagarajan, D. (2018) · Nottingham Trent University's Institutional Repository (Nottingham Trent Repository)
Rapid Synthetic DNA Vaccine Development for Emerging Infectious Disease Outbreaks
Louis, L., & Weiner, D. B. (2019) · Current cancer research · doi:10.1007/978-3-030-04155-7_16
Characterization of Rabbit Monoclonal Antibodies Produced by an HIV-1 Vaccine
Colpas, E. C. (2013) · Digital WPI
DEVELOPING NATURAL KILLER T CELL BASED TOOLS AND STRATEGIES FOR TARGETING BREAST CANCER
Gebremeskel, S. (2019) · DalSpace (Dalhousie University)
Yao, L., Wang, J., Bao, L.-N., Fan, M.-X., Bai, Y., Chen, W., Chen, Y., Li, Y., Wang, J., Li, Y., et al. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.09.077
A COVID-19 Vaccines Review: What We Have Learned So Far and Where Do We Go from Here?Preprint
Wong, S. C. Y., & Morgenstern, C. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3812637
Berge, A. C., Jozan, T., Levesque, C., & Vertenten, G. (2021) · Folia veterinaria · doi:10.2478/fv-2021-0034
Vesin, B., Lopez, J., Noirat, A., Authié, P., Fert, I., le Chevalier, F., Moncoq, F., Nemirov, K., Blanc, C., Planchais, C., et al. (2022) · bioRxiv · doi:10.1101/2022.01.30.478159
Management of Medications Taken by Medically Complex Dental Patients
Weinberg, M. M. A., Froum, S., & Segelnick, S. L. (2020) · doi:10.1002/9781119539384.ch7
Nuevos retos en el desarrollo y uso de vacunas contra la COVID-19.
Esparza, J., García, A. H., Figuera, M. E., & Pujol, F. H. (2022) · Salus · doi:10.54139/salus.v25i3.126
Anticuerpos anti-SARS-CoV-2 en personal de salud de un hospital pediátrico
(2022) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2022-02595
Different Platforms, Immune Response Modulators and Challenges in SARS-CoV-2 Vaccination
Portilho, A. I., Correa, V. A., Gaspar, E. B., & Gaspari, E. D. (2022) · Springer eBooks · doi:10.1007/978-3-031-08045-6_26
Latest in COVID-19 Vaccine 'Candidates' Race
Atoum, M. F. M., Zreig, D. A., & Zreig, L. M. A. (2022) · Infectious Disorders - Drug Targets · doi:10.2174/1871526522666220818124416
Canine Parainfluenza Virus Infection
Ellis, J. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-50934-3.00026-4
Immunotherapy and Cancer Stem Cells
Suryaprakash, R. T. C., Safi, M. A. A., Alonazi, N. A., Alsieedi, A. A., & Kujan, O. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815124606123010007
Epstein-Barr virus and neuroinflammation
Hassani, A., & Khan, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85841-0.00013-4
Vaccine equity and access: A comparative assessment of Covaxin, Covishield, and Sputnik V.
Teli, A., Rathore, P., Kumar, R., & Alam, M. S. (2023) · Indian Journal of Pharmacy and Pharmacology · doi:10.18231/j.ijpp.2023.018
Weiner, D. B., Jansen, K. U., & Villafana, T. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-79058-1.00068-2
Bella, Á. (2024) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · doi:10.15581/10171/69184
SARS-CoV2 and SARS-CoV2 vaccinology
Pinto, R., Kumar, A., & Sachin, K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15241-2.00010-7
COVID-19 hospitalization in vaccinated and non-vaccinated patients: Clinical profile and outcomes
Ferreira, L. H., Bitencourt, E., Gabardo, B. M. A., Pereira, S. E., Teixeira, F., Magatão, D. D. S., Dias, V. L., Petterle, R. R., Nogueira, M. B., & Raboni, S. M. (2025) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2025.104537
Luvira, V., Lawpoolsri, S., Phumratanaprapin, W., Jongkaewwattana, A., Nanthapisal, S., Muangnoicharoen, S., Kamolratanakul, S., Sabmee, Y., Duangdee, C., Narakorn, P., et al. (2025) · Vaccine · doi:10.1016/j.vaccine.2025.127601
Thippeshappa, R., Kulkarni, V., Dwivedi, V., McMillian, J., Argonza, M., Castro, J., Rodriguez, O. L., Maingot, B., Gaži, M., Meredith, R. J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.18.677166
Alesheikh, S., Tazarghi, A., Tabarraei, A., Kianmehr, Z., Akhondi, S., Soleimanjahi, H., Azimi, S. A., & Nikoo, H. R. (2025) · BMC Research Notes · doi:10.1186/s13104-025-07592-7
Optimization of PLGA microspheres for immunotherapy of tumors in the mouse model
Müller, M. U. (2010)
Starrfelt, J., Danielsen, A. S., Buanes, E. A., Juvet, L. K., Lyngstad, T. M., Rø, G., Veneti, L., Watle, S. V., & Meijerink, H. (2022) · Figshare · doi:10.6084/m9.figshare.20786762
Starrfelt, J., Danielsen, A. S., Buanes, E. A., Juvet, L. K., Lyngstad, T. M., Rø, G., Veneti, L., Watle, S. V., & Meijerink, H. (2022) · Figshare · doi:10.6084/m9.figshare.20786759
Morgado-Cáceres, P., Hofmann-Vega, F., Figueroa, D. A., Saavedra-Almarza, J., Gálvez‐Cancino, F., Díaz, X., Menares, E., Roa, E., Hidalgo, S., Varas‐Godoy, M., et al. (2026) · OncoImmunology · doi:10.1080/2162402x.2025.2606497
Kiamba, E. W., Ajiboye, D. O., Bashorun, A. O., Jallow, M. N., Drammeh, L., Bah, S., Jobarteh, T., Kanu, F. J., Jawla, O., Jobarteh, L., et al. (2026) · npj Vaccines · doi:10.1038/s41541-026-01408-w
Current landscape and domestic breakthroughs: A comprehensive review of pet vaccines in China
Zhang, L., Zhang, X., Guo, T., Du, W., Wang, S., & Li, Y. (2026) · Veterinary Vaccine · doi:10.1016/j.vetvac.2026.100158 · Cited by 1
Mac, P. A., Ambu, S. P., Amalraj, F. D., Somanath, S. D., & Chakravarthi, S. (2026) · Vaccine · doi:10.1016/j.vaccine.2026.128554
Sreekanth, S., & Lahon, A. (2026) · Vaccine · doi:10.1016/j.vaccine.2026.128680 · Cited by 1
Kim, D., Lee, J. H., Lee, J. C., Park, J. Y., Shin, Y., Kim, S. J., Cheon, B., Lee, S., Cho, E., Kim, D. R., et al. (2026) · npj Vaccines · doi:10.1038/s41541-026-01483-z
Chen, P., He, X., Bao, H., Wang, Y., Liu, Y., Yu, Q., Zhou, X., Li, W., Deng, G., Shi, J., et al. (2026) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2026.06.009
Marlin, R., Centlivre, M., Bossevot, L., Gallouët, A.-S., Alexandre, M., Planas, D., Cavarelli, M., Staropoli, I., Gros, W., Surénaud, M., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106361 · Cited by 1
Integrating vaccine platforms and delivery routes to improve breadth of influenza immunity
Dharmapal, D., & Ross, T. M. (2026) · Vaccine X · doi:10.1016/j.jvacx.2026.100890
Wiest, M. J., Laghlali, G., d’Acunzo, J., Chung, C., Karadağ, D., Yan, V., Park, S., Noureddine, M., Janczak, K. W., Chen, C., et al. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00539-w
Malaria Vaccine in Healthy Adults
Trials, G. C. T. G. C. (2019) · ImmPort · doi:10.21430/m3fvo9sm7y
Suschak, J. J. (2014) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/m29k5p
Metadata
- Authors
- Lu, S.
- Affiliations
- Jiangsu Province Hospital (CN)
- Corresponding author
- Lu, Shan
- ORCID
- Lu, Shan
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 21
- Issue
- 3
- Pages
- 346-351
- ISSN
- 0952-7915 (ISSN-L)
- PMC
- PMC3743086
- OpenAlex
- W1979742563
- Cited by
- 481
- References
- 40
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 21 · 2023: 32 · 2022: 66 · 2021: 53 · 2020: 41 · 2019: 28 · 2018: 17 · 2017: 27 · 2016: 13 · 2015: 18 · 2014: 21 · 2013: 34 · 2012: 18
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (P01AI082274, R01AI065250, R01 AI06250, U19AI082676)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- heterologous prime-boost, prime-boost vaccination, vaccine immunogenicity, vaccine adjuvants
- MeSH terms
- Animals, Humans, Immunization, Secondary, Neoplasms, Research, Research Design, Vaccination, HIV Infections, AIDS Vaccines, Cancer Vaccines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review