Hepatitis B virus infection, its sequelae, and prevention by vaccination
Abstract
Hepatitis B virus (HBV) infection is a global health problem. There are >350 million of people chronically infected with this virus worldwide. Hepatitis B vaccines are effective in preventing the infection. Humoral immunity is the key factor in conferring the protection. Hepatitis B surface antibody titers of ≥10mIU/mL are protective. Chronic carriage of HBV is related to the age when the infection occurs, the younger the age the higher the chronicity rate. Hence, vaccination should be given in early childhood. People vaccinated in infancy have a protection of >20 years, and hepatocellular carcinoma decreases in them. Although the vaccine-conferred immunity wanes by time, a universal booster is not recommended at present.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Preventive measures such as screening transfused blood for viral hepatitis, employing appropriate medical hygiene in health facilities, introducing hepatitis B vaccination programs, imposing alcohol trade restrictions and raising taxes on alcohol, and implementing health promotion and education programs to reduce alcohol consumption and harmful alcohol use are relatively inexpensive and cost-ef
“By contrast, preventive measures such as screening transfused blood for viral hepatitis, employing appropriate medical hygiene in health facilities, introducing hepatitis B vaccination programs, imposing alcohol trade restrictions and raising taxes on alcohol, implementing health promotion and education programs to reduce alcohol consumption and harmful alcohol use are relatively inexpensive and”
From Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis (2014) · cites this paper as [93]
Cites
HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS
Beasley, R. P., Lin, C., Hwang, L., & Chien, C. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90585-7 · Cited by 2,856 · see citing works
Chang, M.-H., Chen, C.-J., Lai, M.-S., Hsu, H.-M., Wu, T.-C., Kong, M.-S., Liang, D.-C., Shau, W.-Y., & Chen, D.-S. (1997) · New England Journal of Medicine · doi:10.1056/nejm199706263362602 · Cited by 1,883 · see citing works
Self-citationHepatitis B e Antigen and the Risk of Hepatocellular Carcinoma
Yang, H., Lu, S., Liaw, Y., You, S., Sun, C., Wang, L., Hsiao, C. K., Chen, P., Chen, D., & Chen, C. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013215 · Cited by 1,220 · see citing works
Self-citationGenomic analysis of the host response to hepatitis C virus infection
Su, A. I., Pezacki, J. P., Wodicka, L. M., Brideau, A. D., Supeková, Ľ., Thimme, R., Wieland, S. F., Bukh, J., Purcell, R. H., Schultz, P. G., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202608199 · Cited by 1,162 · see citing works
Mast, E. E., Weinbaum, C. M., Fiore, A. E., Alter, M. J., Bell, B. P., Finelli, L., Rodewald, L. E., Douglas, J. M., Janssen, R. S., & Ward, J. W. (2006) · PubMed · Cited by 1,129 · see citing works
Vertical Transmission of Hepatitis B Antigen in Taiwan
Stevens, C. E., Beasley, R. P., Tsui, J., & Lee, W. M. (1975) · New England Journal of Medicine · doi:10.1056/nejm197504102921503 · Cited by 1,026 · see citing works
IMMUNOBIOLOGY AND PATHOGENESIS OF VIRAL HEPATITIS
Guidotti, L. G., & Chisari, F. V. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100230 · Cited by 807 · see citing works
Genomic analysis of the host response to hepatitis B virus infection
Wieland, S. F., Thimme, R., Purcell, R. H., & Chisari, F. V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401771101 · Cited by 651 · see citing works
Decreased Incidence of Hepatocellular Carcinoma in Hepatitis B Vaccinees: A 20-Year Follow-up Study
Chang, M., You, S., Chen, C., Liu, C., Lee, C., Lin, S., Chu, H.-C., Wu, T., Yang, S., Kuo, H., et al. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp288 · Cited by 633 · see citing works
Self-citationKamatani, Y., Wattanapokayakit, S., Ochi, H., Kawaguchi, T., Takahashi, A., Hosono, N., Kubo, M., Tsunoda, T., Kamatani, N., Kumada, H., et al. (2009) · Nature Genetics · doi:10.1038/ng.348 · Cited by 514 · see citing works
Are booster immunisations needed for lifelong hepatitis B immunity?
(2000) · The Lancet · doi:10.1016/s0140-6736(99)07239-6 · Cited by 460 · see citing works
Lok, A. S.-F. (2002) · New England Journal of Medicine · doi:10.1056/nejm200205303462202 · Cited by 450 · see citing works
Incubation Phase of Acute Hepatitis B in Man: Dynamic of Cellular Immune Mechanisms
Webster, G. J. M., Reignat, S., Maini, M. K., Whalley, S. A., Ogg, G. S., King, A., Brown, D. J., Amlot, P. L., Williams, R. L., Vergani, D., et al. (2000) · Hepatology · doi:10.1053/jhep.2000.19324 · Cited by 415 · see citing works
Snyder, R. O., Miao, C., Meuse, L., Tubb, J., Donahue, B. A., Lin, H.-F., Stafford, D. W., Patel, S., Thompson, A. R., Nichols, T., et al. (1999) · Nature Medicine · doi:10.1038/4751 · Cited by 409 · see citing works
The immune response during hepatitis B virus infection
Bertoletti, A., & Gehring, A. J. (2006) · Journal of General Virology · doi:10.1099/vir.0.81920-0 · Cited by 386 · see citing works
Global programme for control of hepatitis B infection
Kane, M. (1995) · Vaccine · doi:10.1016/0264-410x(95)80050-n · Cited by 384 · see citing works
West, D. (1996) · Vaccine · doi:10.1016/0264-410x(96)00062-x · Cited by 379 · see citing works
Chen, D. (1987) · JAMA · doi:10.1001/jama.1987.03390190075023 · Cited by 330 · see citing works
Self-citationFrom Hepatitis to Hepatoma: Lessons from Type B Viral Hepatitis
Chen, D. (1993) · Science · doi:10.1126/science.8211155 · Cited by 328 · see citing works
Self-citationAntibody Levels and Protection after Hepatitis B Vaccination: Results of a 15-Year Follow-up
McMahon, B. J., Bruden, D. L., Petersen, K. M., BULKOW, L. R., Parkinson, A. J., Nainan, O. V., Khristova, M. L., Zanis, C. L., Peters, H. V., & Margolis, H. S. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-5-200503010-00008 · Cited by 315 · see citing works
Recombinant hepatitis B vaccine and the risk of multiple sclerosis
Hernán, M. Á., Jick, S. S., Olek, M. J., & Jick, H. (2004) · Neurology · doi:10.1212/01.wnl.0000138433.61870.82 · Cited by 302 · see citing works
Tsai, S. L., Chen, P., Lai, M., et al. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115590 · Cited by 290 · see citing works
Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B
Chen, D. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.01.002 · Cited by 259 · see citing works
Self-citationHsu, H., Chang, M., Liaw, S., Ni, Y., & Chen, H. (1999) · Hepatology · doi:10.1002/hep.510300511 · Cited by 257 · see citing works
Tsai, W.-L., & Chung, R. T. (2010) · Oncogene · doi:10.1038/onc.2010.36 · Cited by 247 · see citing works
McMahon, B. J., Dentinger, C., Bruden, D. J. T., Zanis, C. L., Peters, H. V., Hurlburt, D., BULKOW, L. R., Fiore, A. E., Bell, B. P., & Hennessy, T. W. (2009) · The Journal of Infectious Diseases · doi:10.1086/606119 · Cited by 246 · see citing works
Lifelong protection against hepatitis B: the role of vaccine immunogenicity in immune memory
Banatvala, J. E., Damme, P. V., & Oehen, S. (2000) · Vaccine · doi:10.1016/s0264-410x(00)00224-3 · Cited by 214 · see citing works
Lu, C., Ni, Y., Chiang, B., Chen, P., Chang, M., Chang, L., Su, I., Kuo, H., Huang, L., Chen, D., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/587695 · Cited by 197 · see citing works
Self-citationLu, C., Chiang, B., Chi, W., et al. (2004) · Hepatology · doi:10.1002/hep.20490 · Cited by 184 · see citing works
Self-citationNo increase in demyelinating diseases after hepatitis B vaccination
Zipp, F., Weil, J., & Einhäupl, K. M. (1999) · Nature Medicine · doi:10.1038/12376 · Cited by 156 · see citing works
Whittle, H., Jaffar, S., Wansbrough, M., et al. (2002) · BMJ · doi:10.1136/bmj.325.7364.569 · Cited by 156 · see citing works
Hsu, H. M., Chen, D., Chuang, C. H., et al. (1988) · PubMed · Cited by 154 · see citing works
Self-citationLong-term protection provided by hepatitis B vaccine and need for booster dose: A meta-analysis
Poorolajal, J., Mahmoodi, M., Majdzadeh, R., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.10.068 · Cited by 142 · see citing works
School-based hepatitis B vaccination programme and adolescent multiple sclerosis
Sadovnick, A. D., & Scheifele, D. W. (2000) · The Lancet · doi:10.1016/s0140-6736(99)02991-8 · Cited by 139 · see citing works
Stevens, C. E., Toy, P. T. C. Y., Taylor, P. E., et al. (1992) · PEDIATRICS · doi:10.1542/peds.90.1.170 · Cited by 135 · see citing works
Frequency of adverse reactions to hepatitis B vaccine in 43,618 persons
McMahon, B. J., Helminiak, C., Wainwright, R. B., BULKOW, L. R., Trimble, B. A., & Wainwright, K. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90073-k · Cited by 132 · see citing works
Wu, J., Wu, T., Chen, C., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.018 · Cited by 125 · see citing works
Jan, C.-F. J., Huang, K., Chien, Y.-C., et al. (2010) · Hepatology · doi:10.1002/hep.23543 · Cited by 113 · see citing works
Lee, P., Lee, C., Huang, L., et al. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70398-5 · Cited by 110 · see citing works
Self-citationGreenberg, D. P. (1993) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199305000-00037 · Cited by 106 · see citing works
Huang, L., Chiang, B., Lee, C., Lee, P., Chi, W., & Chang, M. (1999) · Hepatology · doi:10.1002/hep.510290349 · Cited by 104 · see citing works
Self-citationYUEN, M., Lim, W.-L., Chan, A. O.-O., et al. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00384-2 · Cited by 100 · see citing works
Williams, I. T., Goldstein, S. T., Tufa, J., et al. (2003) · The Pediatric Infectious Disease Journal · doi:10.1097/01.inf.0000050463.28917.25 · Cited by 99 · see citing works
Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection
Hennig, B. J., Fielding, K., Broxholme, J., Diatta, M., Mendy, M. E., Moore, C. E., Pollard, A. J., Rayco‐Solon, P., Sirugo, G., van der Sande, M. A. B., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001898 · Cited by 95 · see citing works
A Shadow Falls on Hepatitis B Vaccination Effort
Marshall, E. (1998) · Science · doi:10.1126/science.281.5377.630 · Cited by 90 · see citing works
Chen, D. (1987) · JAMA · doi:10.1001/jama.257.19.2597 · Cited by 87 · see citing works
Self-citationBut, D. Y., Lai, C., Lim, W.-L., et al. (2008) · Vaccine · doi:10.1016/j.vaccine.2008.09.034 · Cited by 82 · see citing works
The role of hepatitis B virus-specific memory CD8 T cells in the control of viral replication
Sobao, Y., Tomiyama, H., Sugi, K., Tokunaga, M., Ueno, T., Saito, S., Fujiyama, S., Morimoto, M., Tanaka, K., & Takiguchi, M. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00264-1 · Cited by 77 · see citing works
Breakthrough HBV infection in vaccinated children in Taiwan: surveillance for HBV mutants
Chang, M. (2010) · Antiviral Therapy · doi:10.3851/imp1555 · Cited by 74 · see citing works
Safety of immunization and adverse events following vaccination against hepatitis B
DUCLOS, P. J. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00153-3 · Cited by 73 · see citing works
Natural history of chronic hepatitis B virus infection: New light on an old story
Chen, D. (1993) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1993.tb01551.x · Cited by 72 · see citing works
Self-citationLee, C., Huang, L., Chang, M., Hsu, C.-Y., WU, S.-J., Sung, J., & Safary, A. (1991) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199104000-00007 · Cited by 71 · see citing works
Self-citationNakamura, I., Nupp, J. T., Cowlen, M. S., et al. (2001) · Hepatology · doi:10.1053/jhep.2001.21748 · Cited by 69 · see citing works
Comparative Safety of Two Recombinant Hepatitis B Vaccines in Children
Niu, M. T., Rhodes, P., Salive, M. E., et al. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00014-6 · Cited by 67 · see citing works
Immunogenicity of hepatitis B vaccines: implications of immune memory
Koff, R. S. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00405-x · Cited by 66 · see citing works
Wichajarn, K., Kosalaraksa, P., & Wiangnon, S. (2009) · PubMed · Cited by 66 · see citing works
Lieming, D., Mintai, Z., Yinfu, W., et al. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/17.3.475 · Cited by 64 · see citing works
THE CONTROL OF HEPATITIS B VIRUS INFECTION WITH VACCINE IN YUPIK ESKIMOS
Heyward, W. L., Bender, T. R., McMahon, B. J., Hall, D. B., Francis, D. P., Lanier, A. P., Alward, W. L. M., AHTONE, J. L., Murphy, B. L., & Maynard, J. E. (1985) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114061 · Cited by 62 · see citing works
Ding, L., Zhang, M., Wang, Y., et al. (1993) · PubMed · Cited by 60 · see citing works
Milne, A., West, D. J., Chính, Đ. V., et al. (2002) · Journal of Medical Virology · doi:10.1002/jmv.10071 · Cited by 59 · see citing works
Lolekha, S., Warachit, B., Hirunyachote, A., et al. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00358-4 · Cited by 58 · see citing works
Kao, J., Wang, J., Hung, C., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.01.027 · Cited by 58 · see citing works
Hepatitis B vaccine boosters: Is there a clinical need in high endemicity populations?
John, T. J., & Cooksley, G. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2004.03398.x · Cited by 48 · see citing works
Hepatitis B vaccination: to boost or not to boost?
Kao, J., & Chen, D. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67544-7 · Cited by 45 · see citing works
Self-citationHsu, H. M. (1988) · JAMA · doi:10.1001/jama.260.15.2231 · Cited by 31 · see citing works
PONGPIPAT, D., Suvatte, V., & Assateerawatts, A. (1989) · PubMed · Cited by 25 · see citing works
Long-Term Protection of Hepatitis B Vaccine: Lessons from Alaskan Experience after 15 Years
Chen, D. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-5-200503010-00014 · Cited by 21 · see citing works
Self-citationImmunogenicity of HBV vaccine in healthy Chinese children
Hwang, L. Y., PALMERBEASLEY, R., STEVENS, C., et al. (1983) · Vaccine · doi:10.1016/0264-410x(83)90005-1 · Cited by 16 · see citing works
Fujisawa, T., Onoue, M., Inui, A., et al. (1996) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199610000-00011 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis
Mokdad, A. A., Lopez, A. D., Shahraz, S., Lozano, R., Mokdad, A. H., Stanaway, J., Murray, C. J., & Naghavi, M. (2014) · BMC Medicine · doi:10.1186/s12916-014-0145-y · Cited by 1,129 · see citing works
- Authors
- Huang, L.-M., Lu, C.-Y., & Chen, D.-S.
- Affiliations
- National Taiwan University (TW)
- Corresponding author
- Chen, Ding-Shinn
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 23
- Issue
- 2
- Pages
- 237-243
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W1976653428
- Cited by
- 51
- References
- 70
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 15
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Health Sciences › Medicine › Emergency Medicine › Intramuscular injections and effects
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Keywords
- hepatitis B virus, hepatitis B vaccination, chronic hepatitis B, humoral immunity, hepatitis B surface antibody, age at infection, childhood immunization, hepatocellular carcinoma prevention, booster vaccination
- MeSH terms
- Hepatitis B, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Hepatitis B Vaccines, Immunity, Humoral
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
