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Cited by 338

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Targeting the tumor vasculature to enhance T cell activity

Open access
Lanitis, Evripidis, Irving, Melita, Coukos, George·2015·Current Opinion in Immunology
DOI 10.1016/j.coi.2015.01.011
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Abstract

T cells play a critical role in tumor immune surveillance as evidenced by extensive mouse-tumor model studies as well as encouraging patient responses to adoptive T cell therapies and dendritic cell vaccines. It is well established that the interplay of tumor cells with their local cellular environment can trigger events that are immunoinhibitory to T cells. More recently it is emerging that the tumor vasculature itself constitutes an important barrier to T cells. Endothelial cells lining the vessels can suppress T cell activity, target them for destruction, and block them from gaining entry into the tumor in the first place through the deregulation of adhesion molecules. Here we review approaches to break this tumor endothelial barrier and enhance T cell activity.

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Metadata

Authors
Lanitis, E., Irving, M., & Coukos, G.
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2015-04
Volume
33
Pages
55-63
ISSN
0952-7915 (ISSN-L)
DOI
10.1016/j.coi.2015.01.011
OpenAlex
W2071456955
Cited by
338
References
137
FWCI
2.39
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Targeting the tumor vasculature to enhance T cell activity. https://app.cochat.ai/papers/10.1016/j.coi.2015.01.011
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Lanitis, E., Irving, M., & Coukos, G. (2015). Targeting the tumor vasculature to enhance T cell activity. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2015.01.011

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.