Staying local-antigen presentation in the liver
Abstract
The liver is known as organ with unique immune competence. Besides its unique microenvironment that is determined by gut-derived portal venous blood constituents and the presence of enzymes with immune regulatory properties, liver antigen presenting cell populations regulate antigen-specific immunity in a local fashion. In addition to bone marrow-derived dendritic cells and myeloid cells such as macrophages and monocytes, also truly liver-resident cell populations function as antigen presenting cells such as liver sinusoidal endothelial cells and hepatocytes. The functional outcome of antigen-presentation by these cell populations is diverse and ranges from generation of regulatory CD4 cells, to induction of memory CD8 T cells or deletional tolerance, which generates a complex network of antigen-presenting cells that determines hepatic immune regulation and local immune surveillance against viral infection.
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Prior studies have provided evidence for priming of CD8+ T cells within the liver.
“Prior studies have provided evidence for priming of CD8+ T cells within the liver.39,40,68,69”
From TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling (2024) · cites this paper as [39]
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- Authors
- Knolle, P. A.
- Affiliations
- Technical University of Munich (DE)
- Corresponding author
- Knolle, Percy A
- ORCID
- Knolle, Percy A
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 40
- Pages
- 36-42
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2293257104
- Cited by
- 42
- References
- 62
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Immunology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Funders
- Deutsche Forschungsemeinschaft (SFB 704, SFB TR57, SFB TR36)
- EU
- German Center for Infection Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- antigen presentation, liver, hepatic immunity, dendritic cells, liver sinusoidal endothelial cells, hepatocytes, regulatory T cells, memory CD8+ T cells, tolerance (pharmacology and immunology), viral infection, immune surveillance, portal blood
- MeSH terms
- Animals, Antigen-Presenting Cells, Humans, Immune Tolerance, Immunologic Memory, Immunologic Surveillance, Liver, Lymphocyte Activation, Virus Diseases, Antigen Presentation, CD8-Positive T-Lymphocytes, Hepatocytes, T-Lymphocytes, Regulatory, Cellular Microenvironment
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