Cited by 42Immunotherapy and Immune ResponsesLiver physiology and pathologyT-cell and B-cell Immunology

Staying local-antigen presentation in the liver

Knolle, Percy A·2016·Current Opinion in Immunology

Abstract

The liver is known as organ with unique immune competence. Besides its unique microenvironment that is determined by gut-derived portal venous blood constituents and the presence of enzymes with immune regulatory properties, liver antigen presenting cell populations regulate antigen-specific immunity in a local fashion. In addition to bone marrow-derived dendritic cells and myeloid cells such as macrophages and monocytes, also truly liver-resident cell populations function as antigen presenting cells such as liver sinusoidal endothelial cells and hepatocytes. The functional outcome of antigen-presentation by these cell populations is diverse and ranges from generation of regulatory CD4 cells, to induction of memory CD8 T cells or deletional tolerance, which generates a complex network of antigen-presenting cells that determines hepatic immune regulation and local immune surveillance against viral infection.

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Crossref · 10.1016/j.coi.2016.02.009

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Authors
Knolle, P. A.
Affiliations
Technical University of Munich (DE)
Corresponding author
Knolle, Percy A
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2016-06
Volume
40
Pages
36-42
ISSN
0952-7915 (ISSN-L)
OpenAlex
W2293257104
Cited by
42
References
62
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 2
FWCI
0.42
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM (Technical University of Munich) (submittedVersion)
Funders
  • Deutsche Forschungsemeinschaft (SFB 704, SFB TR57, SFB TR36)
  • EU
  • German Center for Infection Research
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
antigen presentation, liver, hepatic immunity, dendritic cells, liver sinusoidal endothelial cells, hepatocytes, regulatory T cells, memory CD8+ T cells, tolerance (pharmacology and immunology), viral infection, immune surveillance, portal blood
MeSH terms
Animals, Antigen-Presenting Cells, Humans, Immune Tolerance, Immunologic Memory, Immunologic Surveillance, Liver, Lymphocyte Activation, Virus Diseases, Antigen Presentation, CD8-Positive T-Lymphocytes, Hepatocytes, T-Lymphocytes, Regulatory, Cellular Microenvironment

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