The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Early innate immune responses to bacterial LPS
Open accessAbstract
A mammalian receptor for bacterial lipopolysaccharide (LPS), Toll-like receptor 4 (TLR4), plays a beneficial role in controlling bacterial infections, but is also a main driver of aberrant inflammation in lethal sepsis. As a result, investigation of TLR4 signaling has been a major area of research. Despite this focus, our understanding of the mechanisms that regulate TLR4 activities remains primitive. Nowhere is our knowledge of TLR4 biology more lacking than at the receptor-proximal level, where many factors act in concert to regulate LPS signaling. Several recent studies have begun filling these gaps in our knowledge. In this review, we discuss the importance of these receptor proximal activities in the spatiotemporal regulation of TLR4 signaling, and suggest interesting areas for future research.
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Cites
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Pyroptosis in inflammatory diseases and cancer
Rao, Z., Zhu, Y., Yang, P., Chen, Z., Xia, Y., Qiao, C., Liu, W., Deng, H., Li, J., Ning, P., et al. (2022) · Theranostics · doi:10.7150/thno.71086 · Cited by 800
Wang, M., Earley, M., Chen, L., Hanson, B. M., Yu, Y., Liu, Z., Salcedo, S., Cober, E., Li, L., Kanj, S. S., et al. (2022) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(21)00399-6 · Cited by 363
Aboudounya, M. M., & Heads, R. J. (2021) · Mediators of Inflammation · doi:10.1155/2021/8874339 · Cited by 346
Toll-like receptors in the pathogenesis of neuroinflammation
Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331
Chen, S.-N., Tan, Y., Xiao, X.-C., Li, Q., Wu, Q., Peng, Y.-Y., Ren, J., & Dong, M.-L. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00597-x · Cited by 259
Metadata
- Authors
- Rosadini, C. V., & Kagan, J. C.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 44
- Pages
- 14-19
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2553446861
- Cited by
- 323
- References
- 42
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- green
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