The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
Open accessAbstract
Move Over, TLR4: The innate immune system senses bacterial lipopolysaccharide (LPS) through Toll-like receptor 4 (TLR4) (see the Perspective by Kagan ). However, Kayagaki et al. (p 1246 , published online 25 July) and Hagar et al. (p. 1250 ) report that the hexa-acyl lipid A component of LPS from Gramnegative bacteria is able to access the cytoplasm and activate caspase-11 to signal immune responses independently of TLR4. Mice that lack caspase-11 are resistant to LPS-induced lethality, even in the presence of TLR4.
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Non-canonical inflammasome activation targets caspase-11
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Self-citationDefective NK Cell Activity and Th1 Response in IL-18–Deficient Mice
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Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
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Self-citationRetrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics
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TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
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Cited by
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
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Self-citationThe M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539
Metadata
- Authors
- Hagar, J. A., Powell, D. A., Aachoui, Y., Ernst, R. K., & Miao, E. A.
- Venue
- Science
- Published
- 2013-09-13
- Volume
- 341
- Issue
- 6151
- Pages
- 1250-1253
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2143102054
- Cited by
- 1,259
- References
- 29
- FWCI
- 30.53
- Type
- journal article
- Language
- en
- Open access
- green
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